NUPR1在肿瘤中的研究进展
Research Progress of NUPR1 in Tumor
DOI: 10.12677/ACM.2024.143830, PDF,   
作者: 任士恒：山东大学齐鲁医学院，山东 济南；山东大学附属山东省立医院胸外科，山东 济南
关键词: NUPR1；自噬；恶性肿瘤；NUPR1； Autophagy； Malignancy
摘要: 核蛋白1 (Nuclear protein 1, NUPR1)是一种位于细胞核内的转录调控因子，可在不同的应激环境和条件下被诱导表达，并参与多种细胞生理过程，如染色质重塑、细胞周期和细胞凋亡。近期研究已经证实，NUPR1可促进多种肿瘤的进展及转移，如非小细胞肺癌、乳腺癌、胰腺癌等。在本综述中，我们旨在讨论NUPR1在恶性肿瘤中的研究进展，为后续NUPR1作为预测肿瘤转移和预后的分子生物标志物指导临床提供新思路。
Abstract: Nuclear protein 1 (NUPR1) is a transcriptional regulator localized in the nucleus. It can be induced under various stress conditions and environments, playing a crucial role in multiple physiological processes, such as chromatin remodeling, cell cycle, and apoptosis. Recent researches have provid-ed evidence that NUPR1 can promote the progression and metastasis of various cancers, including non-small cell lung cancer, breast cancer, pancreatic cancer, etc. This article aims to explore the current research advancements of NUPR1 in malignancy, providing new ideas that NUPR1 may be used as a molecular biomarker for predicting the metastasis and prognosis of cancers.
文章引用：任士恒. NUPR1在肿瘤中的研究进展[J]. 临床医学进展, 2024, 14(3): 1208-1213. https://doi.org/10.12677/ACM.2024.143830

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F. (2021) Global Cancer Sta-tistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Kocaturk, N.M., Akkoc, Y., Kig, C., Bayraktar, O., Gozuacik, D. and Kutlu, O. (2019) Autophagy as a Molecular Target for Cancer Treatment. Eu-ropean Journal of Pharmaceutical Sciences, 134, 116-137. [Google Scholar] [CrossRef] [PubMed]
[3] Newton, K., Strasser, A., Kayagaki, N. and Dixit, V.M. (2024) Cell Death. Cell, 187, 235-256. [Google Scholar] [CrossRef] [PubMed]
[4] Pérez-Herrero, E. and Fernández-Medarde, A. (2015) Advanced Targeted Therapies in Cancer: Drug Nanocarriers, the Future of Chemotherapy. European Journal of Pharmaceutics and Biopharmaceutics, 93, 52-79. [Google Scholar] [CrossRef] [PubMed]
[5] Liu, J., Pandya, P. and Afshar, S. (2021) Therapeutic Advances in Oncology. International Journal of Molecular Sciences, 22, Article 2008. [Google Scholar] [CrossRef] [PubMed]
[6] Chowdhury, U.R., Samant, R.S., Fodstad, O. and Shevde, L.A. (2009) Emerging Role of Nuclear Protein 1 (NUPR1) in Cancer Biology. Cancer and Metastasis Reviews, 28, 225-232. [Google Scholar] [CrossRef] [PubMed]
[7] Murphy, A. and Costa, M. (2020) Nuclear Protein 1 Imparts On-cogenic Potential and Chemotherapeutic Resistance in Cancer. Cancer Letters, 494, 132-141. [Google Scholar] [CrossRef] [PubMed]
[8] Liu, S. and Costa, M. (2022) The Role of NUPR1 in Response to Stress and Cancer Development. Toxicology and Applied Pharmacology, 454, Article 116244. [Google Scholar] [CrossRef] [PubMed]
[9] Mallo, G.V., Fiedler, F., Calvo, E.L., Ortiz, E.M., Vasseur, S., Keim, V., Morisset, J. and Iovanna, J.L. (1997) Cloning and Expression of the Rat p8 cDNA, a New Gene Activated in Pancreas during the Acute Phase of Pancreatitis, Pancreatic Development, and Regeneration, and Which Promotes Cellu-lar Growth. The Journal of Biological Chemistry, 272, 32360-32369. [Google Scholar] [CrossRef] [PubMed]
[10] Zhou, J., Guo, D., Xu, Z.-Z., Liao, J.-S., Li, X.-T., Duan, K., Chen, S.-Y. and Xie, W.-B. (2024) Nupr1-Mediated Vascular Smooth Muscle Cell Phenotype Transformation Involved in Methamphetamine Induces Pulmonary Hypertension. Cell Biology and Toxicology, 40, Article No. 13. [Google Scholar] [CrossRef] [PubMed]
[11] Valacco, M.P., Varone, C., Malicet, C., Cánepa, E., Iovanna, J.L. and Moreno, S. (2006) Cell Growth-Dependent Subcellular Localization of p8. Journal of Cellular Biochemistry, 97, 1066-1079. [Google Scholar] [CrossRef] [PubMed]
[12] Guo, X., Wang, W., Hu, J., Feng, K., Pan, Y., Zhang, L. and Feng, Y. (2012) Lentivirus-Mediated RNAi Knockdown of NUPR1 Inhibits Human Nonsmall Cell Lung Cancer Growth in vitro and in vivo. The Anatomical Record, 295, 2114-2121. [Google Scholar] [CrossRef] [PubMed]
[13] Kim, Y.J., Hong, S.-E., Jang, S.-K., Park, K.S., Kim, C.-H., Park, I.-C. and Jin, H.-O. (2022) Knockdown of NUPR1 En-hances the Sensitivity of Non-Small-Cell Lung Cancer Cells to Metformin by AKT Inhibition. Anticancer Research, 42, 3475-3481. [Google Scholar] [CrossRef] [PubMed]
[14] Ree, A.H., Pacheco, M.M., Tvermyr, M., Fodstad, O. and Brentani, M.M. (2000) Expression of a Novel Factor, Com1, in Early Tumor Progression of Breast Cancer. Clinical Cancer Research, 6, 1778-1783.
[15] Xiao, H., Long, J., Chen, X. and Tan, M.-D. (2022) NUPR1 Promotes the Pro-liferation and Migration of Breast Cancer Cells by Activating TFE3 Transcription to Induce Autophagy. Experimental Cell Research, 418, Article 113234. [Google Scholar] [CrossRef] [PubMed]
[16] Tan, M., He, Y., Yi, J., Chen, J., Guo, Q., Liao, N. and Peng, L. (2023) WTAP Mediates NUPR1 Regulation of LCN2 Through m6A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion. Biochemical Genetics. [Google Scholar] [CrossRef] [PubMed]
[17] Zhang, L., Gao, S., Shi, X., Chen, Y., Wei, S., Mi, Y., Zuo, L. and Qi, C. (2023) NUPR1 Imparts Oncogenic Potential in Bladder Cancer. Cancer Medicine, 12, 7149-7163. [Google Scholar] [CrossRef] [PubMed]
[18] Dong, Y., Ma, W.-M., Shi, Z.-D., Zhang, Z.-G., Zhou, J.-H., Li, Y., Zhang, S.-Q., Pang, K., Li, B.-B., Zhang, W., Fan, T., Zhu, G.-Y., Xue, L., Li, R., Liu, Y., Hao, L. and Han, C.-H. (2021) Role of NRP1 in Bladder Cancer Pathogenesis and Progression. Frontiers in Oncology, 11, Article 685980. [Google Scholar] [CrossRef] [PubMed]
[19] Su, S.-B., Motoo, Y., Iovanna, J.L., Xie, M.-J., Mouri, H., Ohtsubo, K., Yamaguchi, Y., Watanabe, H., Okai, T., Matsubara, F. and Sawabu, N. (2001) Expression of p8 in Human Pancreatic Cancer1. Clinical Cancer Research, 7, 309-313. [Google Scholar] [CrossRef] [PubMed]
[20] Su, S.B., Mo-too, Y., Iovanna, J.L., Berthézène, P., Xie, M.J., Mouri, H., Ohtsubo, K., Matsubara, F. and Sawabu, N. (2001) Overex-pression of p8 Is Inversely Correlated with Apoptosis in Pancreatic Cancer. Clinical Cancer Research, 7, 1320-1324.
[21] Malicet, C., Lesavre, N., Vasseur, S. and Iovanna, J.L. (2003) p8 Inhibits the Growth of Human Pan-creatic Cancer Cells and Its Expression Is Induced through Pathways Involved in Growth Inhibition and Repressed by Factors Promoting Cell Growth. Molecular Cancer, 2, Article No. 37. [Google Scholar] [CrossRef] [PubMed]
[22] Ito, Y., Yoshida, H., Motoo, Y., Miyoshi, E., Iovanna, J.L., Tomoda, C., Uruno, T., Takamura, Y., Miya, A., Kobayashi, K., Matsuzuka, F., Matsuura, N., Kuma, K. and Miyauchi, A. (2003) Expression and Cellular Localization of p8 Protein in Thyroid Neoplasms. Cancer Letters, 201, 237-244. [Google Scholar] [CrossRef] [PubMed]
[23] Ito, Y., Yoshida, H., Motoo, Y., Iovanna, J.L., Tomoda, C., Uruno, T., Takamura, Y., Miya, A, Kobayashi, K., Matsuzuka, F., Kuma, K. and Miyauchi, A. (2005) Expression of p8 Protein in Medullary Thyroid Carcinoma. Anticancer Research, 25, 3419-3423.
[24] Fan, T., Wang, X., Zhang, S., Deng, P., Jiang, Y., Liang, Y., Jie, S., Wang, Q., Li, C., Tian, G., Zhang, Z., Ren, Z., Li, B., Chen, Y., He, Z., Luo, Y., Chen, M., Wu, H., Yu, Z., Pi, H., Zhou, Z. and Zhang, Z. (2022) NUPR1 Promotes the Proliferation and Metastasis of Oral Squamous Cell Carcinoma Cells by Activating TFE3-Dependent Autophagy. Signal Transduction and Targeted Therapy, 7, Article No. 130. [Google Scholar] [CrossRef] [PubMed]

为你推荐