肠道菌群及其代谢产物与卵巢子宫内膜异位症关系的研究进展

Research Progress on the Relationship between Gut Microbiota and Its Metabolites and Ovarian Endometriosis

摘要: 子宫内膜异位症(EMT)是妇科中一种常见的激素依赖性疾病，主要影响育龄期女性。此病具有与恶性肿瘤相似的特性，如黏附、侵袭和转移，并且容易反复发作，对女性患者的身心健康和生活质量产生严重影响。尽管目前EMT的发病机制尚未完全明确，但已有研究指出肠道菌群失衡在其发病过程中起到了关键作用。肠道菌群失衡可能导致EMT的发生和发展，这可能与脂多糖生成、炎症因子及血管生成素的释放、雌激素水平等机制有关。因此，通过检测肠道菌群来实现EMT的早期诊断，并尝试通过调整肠道菌群、改善肠道微环境，来预防疾病的发生和进展，这可能是一种有效的策略。

Abstract: Endometriosis (EMT) is a common hormone dependent disease in gynecology, mainly affecting women of childbearing age. This disease has characteristics similar to malignant tumors, such as adhesion, invasion, and metastasis, and is prone to recurrence, which seriously affects the physical and mental health and quality of life of female patients. Although the pathogenesis of EMT is not yet fully understood, studies have shown that gut microbiota imbalance plays a crucial role in its path-ogenesis. Imbalance of gut microbiota may lead to the occurrence and development of EMT, which may be related to mechanisms such as lipopolysaccharide production, release of inflammatory fac-tors and angiopoietin, and estrogen levels. Therefore, early diagnosis of EMT can be achieved by detecting gut microbiota, and attempting to prevent disease occurrence and progression by adjust-ing gut microbiota and improving gut microenvironment may be an effective strategy.