系统性红斑狼疮患者外周血BLyS表达水平变化与CD19⁺CD24^hiCD27⁺ Breg细胞关系的相关性研究

Correlation Study between Changes in Peripheral Blood BLyS Expression Levels and CD19⁺CD24^hiCD27⁺ Breg Cells in Patients with Systemic Lupus Erythematosus

摘要: 目的：此文旨在研究系统性红斑狼疮(SLE)患者外周血BLyS的表达水平与CD19⁺CD24^hiCD27⁺ Breg细胞表达比例的相关性，为寻求SLE个体化免疫治疗策略提供理论依据。实验方法：选择SLE患者40例，根据SLEDAI-2k评分分为低活动度组(评分 ≤ 9)；中高活动度组(评分 ≥ 10)，并选取健康查体患者37例，分析受试者外周血Breg细胞比例水平、BLyS水平、临床指标等。结果：SLE患者外周血Breg表达水平低于健康人，且与疾病活动度负相关；SLE患者的BLys表达水平高于健康人，且与疾病活动度正相关；BLyS表达水平与Breg细胞比例表达水平存在负相关性。结论：系统性红斑狼疮的发病可能与Breg细胞的负性调节作用减弱有关；BlyS可能参与了系统性红斑狼疮的疾病进展，为探究此细胞在系统性红斑狼疮发病机制方面提供了一些新的思路。

Abstract: Objective: This article aims to investigate the correlation between the expression level of peripheral blood BLyS and the expression ratio of CD19⁺CD24^hiCD27⁺ Breg cells in patients with systemic lupus erythematosus (SLE), providing a theoretical basis for seeking personalized immunotherapy strategies for SLE. Experimental Method: Forty SLE patients were selected and divided into a low activity group (score ≤ 9) based on the SLEDAI-2k score; Middle to high activity group (score ≥ 10), and 37 healthy physical examination patients were selected to analyze the proportion of peripheral blood Breg cells, BLyS levels, clinical indicators, etc. Result: The expression level of Breg in peripheral blood of SLE patients was lower than that of healthy individuals, and it was negatively correlated with disease activity; the expression level of BLys in SLE patients is higher than that in healthy individuals and positively correlated with disease activity; there is a negative correlation between the expression level of BLyS and the proportion expression level of Breg cells. Conclusion: The pathogenesis of systemic lupus erythematosus may be related to the weakened negative regulatory effect of Breg cells; BlyS may be involved in the progression of systemic lupus erythematosus, providing new insights into the role of this cell in the pathogenesis of systemic lupus erythematosus.