青年胃癌患者的临床特点及研究进展
Clinical Characteristics and Research Progress of Young Patients with Gastric Cancer
DOI: 10.12677/acm.2024.143867, PDF,   
作者: 刘 鹏:延安大学第一临床医学院,陕西 延安;李小宝*:延安大学附属医院胃肠外科,陕西 延安
关键词: 青年胃癌临床特点治疗预后Gastric Cancer in Youth Clinical Characteristics Treatment Prognosis
摘要: 胃癌(Gastric Cancer, GC)是指异质性较高的癌变发生于患者胃黏膜上皮组织,是来源于上消化道肿瘤的一种。GC发病率呈增加趋势,发病年龄呈低龄化趋势。中老年患者多见,特别是45~70岁,因此青年GC患者往往被忽视。为进一步认识青年GC的特点,本文重点就青年GC的流行病学与病因学,临床病理与基因特征,研究现状,治疗与预后等方面进行了阐述,希望能够为青年GC患者的预防及治疗带来一定的帮助。
Abstract: Gastric Cancer (GC) is a type of upper digestive tract tumor that is characterized by high heterogeneity and occurs in the gastric mucosal epithelial tissue of patients. The incidence of GC was increasing and the age of onset was younger. Middle-aged and elderly patients are more common, especially 45~70 years old, so young GC patients are often overlooked. In order to further understand the special points of GC in young people, this paper focuses on the epidemiology and etiology, clinicopathology and genetic characteristics, research status, treatment and prognosis of GC in young people, hoping to bring some help for the prevention and treatment of GC in young people.
文章引用:刘鹏, 李小宝. 青年胃癌患者的临床特点及研究进展[J]. 临床医学进展, 2024, 14(3): 1468-1476. https://doi.org/10.12677/acm.2024.143867

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Ramos, M., Pereira, M.A., Sagae, V.M.T., et al. (2019) Gastric Cancer in Young Adults: A Worse Prognosis Group? Revista do Colégio Brasileiro de Cirurgiões, 46, e20192256.
[3] Takatsu, Y., Hiki, N., Nunobe, S., et al. (2016) Clinicopathological Features of Gastric Cancer in Young Patients. Gastric Cancer, 19, 472-478. [Google Scholar] [CrossRef] [PubMed]
[4] Rona, K.A., Schwameis, K., Zehetner, J., et al. (2017) Gastric Cancer in the Young: An Advanced Disease with Poor Prognostic Features. Journal of Surgical Oncology, 115, 371-375. [Google Scholar] [CrossRef] [PubMed]
[5] Thrift, A.P. and El-Serag, H.B. (2020) Burden of Gastric Cancer. Clinical Gastroenterology and Hepatology, 18, 534-542. [Google Scholar] [CrossRef] [PubMed]
[6] Health Commission of the People’s Republic of China (2022) National Guidelines for Diagnosis and Treatment of Gastric Cancer 2022 in China (English Version). Chinese Journal of Cancer Research, 34, 207-237. [Google Scholar] [CrossRef] [PubMed]
[7] 宋子涵, 徐欣宁, 李昆临, 等. 胃癌病因学研究进展[J]. 中国冶金工业医学杂志, 2020, 37(5): 509-511.
[8] Eto, K., Ohyama, S., Yamaguchi, T., et al. (2006) Familial Clustering in Subgroups of Gastric Cancer Stratified by Histology, Age Group and Location. European Journal of Surgical Oncology, 32, 743-748. [Google Scholar] [CrossRef] [PubMed]
[9] Plummer, M., Franceschi, S., Vignat, J., et al. (2015) Global Burden of Gastric Cancer Attributable to Helicobacter pylori. International Journal of Cancer, 136, 487-490. [Google Scholar] [CrossRef] [PubMed]
[10] Chang, W.L., Yeh, Y.C. and Sheu, B.S. (2018) The Impacts of H. pylori Virulence Factors on the Development of Gastroduodenal Diseases. Journal of Biomedical Science, 25, Article No. 68. [Google Scholar] [CrossRef] [PubMed]
[11] Song, H.J. and Kim, K.M. (2011) Pathology of Epstein-Barr Virus-Associated Gastric Carcinoma and Its Relationship to Prognosis. Gut and Liver, 5, 143-148. [Google Scholar] [CrossRef] [PubMed]
[12] Bergquist, J.R., Leiting, J.L., Habermann, E.B., et al. (2019) Early-Onset Gastric Cancer Is a Distinct Disease with Worrisome Trends and Oncogenic Features. Surgery, 166, 547-555. [Google Scholar] [CrossRef] [PubMed]
[13] Wong, M.C.S., Huang, J., Chan, P.S.F., et al. (2021) Global Incidence and Mortality of Gastric Cancer, 1980-2018. JAMA Network Open, 4, e2118457. [Google Scholar] [CrossRef] [PubMed]
[14] D’Elia, L., Rossi, G., Ippolito, R., et al. (2012) Habitual Salt Intake and Risk of Gastric Cancer: A Meta-Analysis of Prospective Studies. Clinical Nutrition, 31, 489-498. [Google Scholar] [CrossRef] [PubMed]
[15] Kurosawa, M., Kikuchi, S., Xu, J., et al. (2006) Highly Salted Food and Mountain Herbs Elevate the Risk for Stomach Cancer Death in a Rural Area of Japan. Journal of Gastroenterology and Hepatology, 21, 1681-1686. [Google Scholar] [CrossRef] [PubMed]
[16] Fang, X., Wei, J., He, X., et al. (2015) Landscape of Dietary Factors Associated with Risk of Gastric Cancer: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. European Journal of Cancer, 51, 2820-2832. [Google Scholar] [CrossRef] [PubMed]
[17] Bouras, E., Tsilidis, K.K., Triggi, M., et al. (2022) Diet and Risk of Gastric Cancer: An Umbrella Review. Nutrients, 14, Article 1764. [Google Scholar] [CrossRef] [PubMed]
[18] Liu, R.H. (2013) Health-Promoting Components of Fruits and Vegetables in the Diet. Advances in Nutrition, 4, 384S-392S. [Google Scholar] [CrossRef] [PubMed]
[19] Ghaffari, H.R., Yunesian, M., Nabizadeh, R., et al. (2019) Environmental Etiology of Gastric Cancer in Iran: A Systematic Review Focusing on Drinking Water, Soil, Food, Radiation, and Geographical Conditions. Environmental Science and Pollution Research International, 26, 10487-10495. [Google Scholar] [CrossRef] [PubMed]
[20] Edgren, G., Hjalgrim, H., Rostgaard, K., et al. (2010) Risk of Gastric Cancer and Peptic Ulcers in Relation to ABO Blood Type: A Cohort Study. American Journal of Epidemiology, 172, 1280-1285. [Google Scholar] [CrossRef] [PubMed]
[21] Liu, S., Feng, F., Xu, G., et al. (2016) Clinicopathological Features and Prognosis of Gastric Cancer in Young Patients. BMC Cancer, 16, Article No. 478. [Google Scholar] [CrossRef] [PubMed]
[22] Zhang, X., Liu, F., Bao, H., et al. (2021) Distinct Genomic Profile in H. pylori-Associated Gastric Cancer. Cancer Medicine, 10, 2461-2469. [Google Scholar] [CrossRef] [PubMed]
[23] Cho, S.Y., Park, J.W., Liu, Y., et al. (2017) Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared with Late-Onset Cancers. Gastroenterology, 153, 536-549.e26. [Google Scholar] [CrossRef] [PubMed]
[24] Setia, N., Wang, C.X., Lager, A., et al. (2021) Morphologic and Molecular Analysis of Early-Onset Gastric Cancer. Cancer, 127, 103-114. [Google Scholar] [CrossRef] [PubMed]
[25] Zhang, J., Wong, C.C., Leung, K.T., et al. (2020) FGF18-FGFR2 Signaling Triggers the Activation of C-Jun-YAP1 Axis to Promote Carcinogenesis in a Subgroup of Gastric Cancer Patients and Indicates Translational Potential. Oncogene, 39, 6647-6663. [Google Scholar] [CrossRef] [PubMed]
[26] Zhou, Q., Tao, F., Qiu, L., et al. (2022) Somatic Alteration Characteristics of Early-Onset Gastric Cancer. Journal of Oncology, 2022, Article ID: 1498053. [Google Scholar] [CrossRef] [PubMed]
[27] Zhang, X., Liu, J., Liang, X., et al. (2016) History and Progression of Fat Cadherins in Health and Disease. OncoTargets and Therapy, 9, 7337-7343. [Google Scholar] [CrossRef
[28] Cai, J., Feng, D., Hu, L., et al. (2015) FAT4 Functions as a Tumour Suppressor in Gastric Cancer by Modulating Wnt/β-Catenin Signalling. British Journal of Cancer, 113, 1720-1729. [Google Scholar] [CrossRef] [PubMed]
[29] 苗儒林, 李子禹, 季加孚. 从中国胃肠肿瘤外科联盟相关数据分析我国早期胃癌诊治现状和发展趋势[J]. 中国实用外科杂志, 2019, 39(5): 419-423.
[30] Pyo, J.H., Lee, H., Min, B.H., et al. (2016) Long-Term Outcome of Endoscopic Resection vs. Surgery for Early Gastric Cancer: A Non-Inferiority-Matched Cohort Study. American Journal of Gastroenterology, 111, 240-249. [Google Scholar] [CrossRef] [PubMed]
[31] Tao, M., Zhou, X., Hu, M., et al. (2019) Endoscopic Submucosal Dissection versus Endoscopic Mucosal Resection for Patients with Early Gastric Cancer: A Meta-Analysis. BMJ Open, 9, e025803. [Google Scholar] [CrossRef] [PubMed]
[32] Huang, H.L., Leung, C.Y., Saito, E., et al. (2020) Effect and Cost-Effectiveness of National Gastric Cancer Screening in Japan: A Microsimulation Modeling Study. BMC Medicine, 18, Article No. 257. [Google Scholar] [CrossRef] [PubMed]
[33] Johnston, F.M. and Beckman, M. (2019) Updates on Management of Gastric Cancer. Current Oncology Reports, 21, Article No. 67. [Google Scholar] [CrossRef] [PubMed]
[34] Sexton, R.E., Al Hallak, M.N., Diab, M., et al. (2020) Gastric Cancer: A Comprehensive Review of Current and Future Treatment Strategies. Cancer and Metastasis Reviews, 39, 1179-1203. [Google Scholar] [CrossRef] [PubMed]
[35] Kim, H.I., Han, S.U., Yang, H.K., et al. (2016) Multicenter Prospective Comparative Study of Robotic versus Laparoscopic Gastrectomy for Gastric Adenocarcinoma. Annals of Surgery, 263, 103-109. [Google Scholar] [CrossRef
[36] Kist, M., Thomaschewski, M., Keck, Y., et al. (2022) Specifics of Young Gastric Cancer Patients: A Population-Based Analysis of 46,110 Patients with Gastric Cancer from the German Clinical Cancer Registry Group. Cancers (Basel), 14, Article 5927. [Google Scholar] [CrossRef] [PubMed]
[37] Satake, H., Kondo, M., Mizumoto, M., et al. (2017) Phase I Study of Neoadjuvant Chemotherapy with Capecitabine and Oxaliplatin for Locally Advanced Gastric Cancer. Anticancer Research, 37, 3703-3710. [Google Scholar] [CrossRef] [PubMed]
[38] Bang, Y.J., Van Cutsem, E., Feyereislova, A., et al. (2010) Trastuzumab in Combination with Chemotherapy versus Chemotherapy Alone for Treatment of HER2-Positive Advanced Gastric or Gastro-Oesophageal Junction Cancer (ToGA): A Phase 3, Open-Label, Randomised Controlled Trial. The Lancet, 376, 687-697. [Google Scholar] [CrossRef
[39] Wagner, A.D., Syn, N.L., Moehler, M., et al. (2017) Chemotherapy for Advanced Gastric Cancer. Cochrane Database of Systematic Reviews, No. 8, CD004064. [Google Scholar] [CrossRef
[40] Pardoll, D.M. (2012) The Blockade of Immune Checkpoints in Cancer Immunotherapy. Nature Reviews Cancer, 12, 252-264. [Google Scholar] [CrossRef] [PubMed]
[41] Li, K., Zhang, A., Li, X., et al. (2021) Advances in Clinical Immunotherapy for Gastric Cancer. Biochimica et Biophysica Acta, 1876, Article 188615. [Google Scholar] [CrossRef] [PubMed]
[42] 蔡钢, 王舒蓓, 陈佳艺. 放射治疗在胃癌全程管理中的现状与挑战[J]. 中国癌症杂志, 2022, 32(7): 581-587.
[43] Lauren, P. (1965) The Two Histological Main Types of Gastric Carcinoma: Diffuse and So-Called Intestinal-Type Carcinoma. An Attempt at a Histo-Clinical Classification. Acta Pathologica et Microbiologica Scandinavica, 64, 31-49. [Google Scholar] [CrossRef] [PubMed]
[44] 潘修勇, 杨进华, 张锡贵. 青年人胃癌53例临床分析[J]. 中国现代医生, 2009, 47(12): 149-150.
[45] Chen, Y.C., Fang, W.L., Wang, R.F., et al. (2016) Clinicopathological Variation of Lauren Classification in Gastric Cancer. Pathology and Oncology Research, 22, 197-202. [Google Scholar] [CrossRef] [PubMed]