炎性衰老在老年衰弱综合征中的发生机制
The Mechanism of Inflamm-Aging in Elderly Frailty Syndrome
DOI: 10.12677/acm.2024.143869, PDF,   
作者: 米叶赛·艾尼瓦尔:新疆医科大学第一附属医院,新疆 乌鲁木齐;王 红*:新疆医科大学第一附属医院综合内二科,新疆 乌鲁木齐
关键词: 衰弱炎性衰老机制Frailty Inflamm-Aging Mechanisms
摘要: 衰弱是一种与增龄相关的老年综合征,增加老年人不良健康结局的风险,减少预期寿命。炎性衰老(inflamm-aging)是机体在衰老过程中所显现出的慢性促炎症反应状态,并随着衰老而进行性加剧。研究表明,炎性衰老可能是导致衰弱的重要原因。本文对炎性衰老和老年人衰弱综合征的机制进行综述,为衰弱的早期诊断和干预提供理论依据。
Abstract: Frailty is a geriatric syndrome associated with increasing age, increasing the risk of adverse health outcomes and decreasing life expectancy in older adults. Inflamm-aging is a chronic pro-inflammatory response state of the body that manifests itself during the aging process and progressively intensifies with aging. Research suggests that inflamm-aging may be an important cause of frailty. In this paper, we review the mechanisms of inflamm-aging and debilitating syndromes in the elderly to provide a theoretical basis for early diagnosis and intervention of frailty.
文章引用:米叶赛·艾尼瓦尔, 王红. 炎性衰老在老年衰弱综合征中的发生机制[J]. 临床医学进展, 2024, 14(3): 1487-1492. https://doi.org/10.12677/acm.2024.143869

参考文献

[1] Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C., Gottdiener, J., et al. (2001) Frailty in Older Adults: Evidence for a Phenotype. The Journals of Gerontology: Series A, 56, M146-M157. [Google Scholar] [CrossRef
[2] Dent, E., Lien, C., Lim, W.S., et al. (2017) The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty. Journal of the American Medical Directors Association, 18, 564-575. [Google Scholar] [CrossRef] [PubMed]
[3] He, B., Ma, Y., Wang, C., et al. (2019) Prevalence and Risk Factors for Frailty among Community-Dwelling Older People in China: A Systematic Review and Meta-Analysis. The Journal of Nutrition, Health and Aging, 23, 442-450. [Google Scholar] [CrossRef] [PubMed]
[4] Gao, K., Li, B.-L., Yang, L., Zhou, D., Ding, K.-X., Yan, J., Gao, Y.-J., Huang, X.-R. and Zheng, X.-P. (2021) Cardiometabolic Diseases, Frailty, and Healthcare Utilization and Expenditure in Community-Dwelling Chinese Older Adults. Scientific Reports, 11, Article No. 7776. [Google Scholar] [CrossRef] [PubMed]
[5] Franceschi, C., Garagnani, P., Vitale, G., Capri, M. and Salvioli, S. (2017) Inflammaging and ‘Garb-aging’. Trends in Endocrinology & Metabolism, 28, 199-212. [Google Scholar] [CrossRef] [PubMed]
[6] 马丽娜. 老年人衰弱综合征与慢性系统性炎症: 思考与展望[J]. 中华老年多器官疾病杂志, 2021, 20(2): 140-143. [Google Scholar] [CrossRef
[7] Zhang, W., Qu, J., Liu, G.-H. and Belmonte, J.C.I. (2020) The Ageing Epigenome and Its Rejuvenation. Nature Reviews Molecular Cell Biology, 21, 137-150. [Google Scholar] [CrossRef] [PubMed]
[8] Smith, A.J. and Humphries, S.E. (2009) Cytokine and Cytokine Receptor Gene Polymorphisms and Their Functionality. Cytokine & Growth Factor Reviews, 20, 43-59. [Google Scholar] [CrossRef] [PubMed]
[9] IL6R Genetics Consortium Emerging Risk Factors Collaboration (2012) Interleukin-6 Receptor Pathways in Coronary Heart Disease: A Collaborative Meta-Analysis of 82 Studies. The Lancet, 379, 1205-1213. [Google Scholar] [CrossRef
[10] Schnabel, R.B., Kerr, K.F., Lubitz, S.A., Alkylbekova, E.L., Marcus, G.M., Sinner, M.F., et al. (2011) Large-Scale Candidate Gene Analysis in Whites and African Americans Identifies IL6R Polymorphism in Relation to Atrial Fibrillation: The National Heart, Lung, and Blood Institute’s Candidate Gene Association Resource (CARe) Project. Circulation: Cardiovascular Genetics, 4, 557-564. [Google Scholar] [CrossRef
[11] Hewitt, G., Jurk, D., Marques, F.D., Correia-Melo, C., Hardy, T., Gackowska, A., Anderson, R., Taschuk, M., Mann, J. and Passos, J.F. (2012) Telomeres Are Favoured Targets of a Persistent DNA Damage Response in Ageing and Stress-Induced Senescence. Nature Communications, 3, Article No. 708. [Google Scholar] [CrossRef] [PubMed]
[12] Olivieri, F., Albertini, M.C., Orciani, M., Ceka, A., Cricca, M., Procopio, A.D. and Bonafè, M. (2015) DNA Damage Response (DDR) and Senescence: Shuttled Inflamma-Mirnas on the Stage of Inflamm-Aging. Oncotarget, 6, 35509-35521. [Google Scholar] [CrossRef] [PubMed]
[13] Olivieri, F., Bonafè, M., Spazzafumo, L., Gobbi, M., Prattichizzo, F., Recchioni, R., Marcheselli, F., La Sala, L., Galeazzi, R., Rippo, M.R., Fulgenzi, G., Angelini, S., Lazzarini, R., Bonfigli, A.R., Brugè, F., Tiano, L., Genovese, S., Ceriello, A., Boemi, M., Franceschi, C., Procopio, A.D. and Testa, R. (2014) Age-and Glycemia-Related miR-126-3p Levels in Plasma and Endothelial Cells. Aging, 6, 771-786. [Google Scholar] [CrossRef] [PubMed]
[14] Franceschi, C. and Campisi, J. (2014) Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases. The Journals of Gerontology: Series A, 69, S4-S9. [Google Scholar] [CrossRef] [PubMed]
[15] Hernandez-Segura, A., De Jong, T.V., Melov, S., Guryev, V., Campisi, J. and Demaria, M. (2017) Unmasking Transcriptional Heterogeneity in Senescent Cells. Current Biology, 27, 2652-2660. [Google Scholar] [CrossRef] [PubMed]
[16] Borodkina, A.V., Deryabin, P.I., Giukova, A.A. and Nikolsky, N.N. (2018) “Social Life” of Senescent Cells: What Is SASP and Why Study It? ActaNaturae, 10, 4-14. [Google Scholar] [CrossRef
[17] Ogrodnik, M. (2021) Cellular Aging beyond Cellular Senescence: Markers of Senescence Prior to Cell Cycle Arrest in vitro and in vivo. Aging Cell, 20, e13338. [Google Scholar] [CrossRef] [PubMed]
[18] Sadighi Akha, A.A. (2018) Aging and the Immune System: An Overview. Journal of Immunological Methods, 463, 21-26. [Google Scholar] [CrossRef] [PubMed]
[19] Castelo-Branco, C. and Soveral, I. (2014) The Immune System and Aging: A Review. Gynecological Endocrinology, 30, 16-22. [Google Scholar] [CrossRef] [PubMed]
[20] Shaw, A.C., Goldstein, D.R. and Montgomery, R.R. (2013) Age-Dependent Dysregulation of Innate Immunity. Nature Reviews Immunology, 13, 875-887. [Google Scholar] [CrossRef] [PubMed]
[21] Kelley, N., Jeltema, D., Duan, Y. and He, Y. (2019) The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. International Journal of Molecular Sciences, 20, Article 3328. [Google Scholar] [CrossRef] [PubMed]
[22] Afonina, I.S., Zhong, Z., Karin, M. and Beyaert, R. (2017) Limiting Inflammation—The Negative Regulation of NF-κB and the NLRP3 Inflammasome. Nature Immunology, 18, 861-869. [Google Scholar] [CrossRef] [PubMed]
[23] Youm, Y.H., Grant, R.W., McCabe, L.R., Albarado, D.C., Nguyen, K.Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., Münzberg, H., Rosen, C.J., Ingram, D.K., Salbaum, J.M. and Dixit, V.D. (2013) Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging. Cell Metabolism, 18, 519-532. [Google Scholar] [CrossRef] [PubMed]
[24] Biasizzo, M. and Kopitar-Jerala, N. (2020) Interplay between NLRP3 Inflammasome and Autophagy. Frontiers in Immunology, 11, Article 591803. [Google Scholar] [CrossRef] [PubMed]
[25] Wong, S.Q., Kumar, A.V., Mills, J. and Lapierre, L.R. (2020) Autophagy in Aging and Longevity. Human Genetics, 139, 277-290. [Google Scholar] [CrossRef] [PubMed]
[26] Chen, G., Kroemer, G. and Kepp, O. (2020) Mitophagy: An Emerging Role in Aging and Age-Associated Diseases. Frontiers in Cell and Developmental Biology, 8, Article 200. [Google Scholar] [CrossRef] [PubMed]
[27] Ajoolabady, A., Aslkhodapasandhokmabad, H., Aghanejad, A., Zhang, Y. and Ren, J. (2020) Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing. Ageing Research Reviews, 62, Article 101129. [Google Scholar] [CrossRef] [PubMed]
[28] Yu, J., Nagasu, H., Murakami, T., Hoang, H., Broderick, L., Hoffman, H.M. and Horng, T. (2014) Inflammasome Activation Leads to Caspase-1-Dependent Mitochondrial Damage and Block of Mitophagy. Proceedings of the National Academy of Sciences, 111, 15514-15519. [Google Scholar] [CrossRef] [PubMed]
[29] Fougère, B., Boulanger, E., Nourhashémi, F., Guyonnet, S. and Cesari, M. (2017) Chronic Inflammation: Accelerator of Biological Aging. The Journals of Gerontology: Series A, 72, 1218-1225. [Google Scholar] [CrossRef] [PubMed]
[30] Santos-Eggimann, B., Cuénoud, P., Spagnoli, J. and Junod, J. (2009) Prevalence of Frailty in Middle-Aged and Older Community-Dwelling Europeans Living in 10 Countries. The Journals of Gerontology: Series A, 64A, 675-681. [Google Scholar] [CrossRef] [PubMed]
[31] Piggott, D.A., Bandeen-Roche, K., Mehta, S.H., Brown, T.T., Yang, H., Walston, J.D., Leng, S.X. and Kirk, G.D. (2020) Frailty Transitions, Inflammation, and Mortality among Persons Aging with HIV Infection and Injection Drug Use. AIDS, 34, 1217-1225. [Google Scholar] [CrossRef
[32] Fabbri, E., An, Y., Zoli, M., Simonsick, E.M., Guralnik, J.M., Bandinelli, S., Boyd, C.M. and Ferrucci, L. (2015) Aging and the Burden of Multimorbidity: Associations with Inflammatory and Anabolic Hormonal Biomarkers. The Journals of Gerontology: Series A, 70, 63-70. [Google Scholar] [CrossRef] [PubMed]
[33] Viña, J., Tarazona-Santabalbina, F.J., Pérez-Ros, P., Martínez-Arnau, F.M., Borras, C., Olaso-Gonzalez, G., Salvador-Pascual, A. and Gomez-Cabrera, M.C. (2016) Biology of Frailty: Modulation of Ageing Genes and Its Importance to Prevent Age-Associated Loss of Function. Molecular Aspects of Medicine, 50, 88-108. [Google Scholar] [CrossRef] [PubMed]
[34] Poursalehi, D., Lotfi, K. and Saneei, P. (2023) Adherence to the Mediterranean Diet and Risk of Frailty and Pre-Frailty in Elderly Adults: A Systematic Review and Dose-Response Meta-Analysis with Grade Assessment. Ageing Research Reviews, 87, Article 101903. [Google Scholar] [CrossRef] [PubMed]
[35] Landi, F., Marzetti, E., Liperoti, R., Pahor, M., Russo, A., Martone, A.M., Colloca, G., Capoluongo, E. and Bernabei, R. (2013) Nonsteroidal Anti-Inflammatory Drug (NSAID) Use and Sarcopenia in Older People: Results from the ilSIRENTE Study. Journal of the American Medical Directors Association, 14, 626, E9-E13. [Google Scholar] [CrossRef] [PubMed]
[36] Wang, C.P., Lorenzo, C., Habib, S.L., Jo, B. and Espinoza, S.E. (2017) Differential Effects of Metformin on Age Related Comorbidities in Older Men with Type 2 Diabetes. Journal of Diabetes and Its Complications, 31, 679-686. [Google Scholar] [CrossRef] [PubMed]
[37] Ferrucci, L. and Fabbri, E. (2018) Inflammageing: Chronic Inflammation in Ageing, Cardiovascular Disease, and Frailty. Nature Reviews Cardiology, 15, 505-522. [Google Scholar] [CrossRef] [PubMed]