益气散结颗粒治疗肺结节气虚痰淤证29例

29 Cases of Pulmonary Nodules with Qi Deficiency and Phlegm Stasis Syndrome Treated with Yiqi Sanjie Granules

摘要: 目的：观察益气散结颗粒治疗肺结节气虚痰瘀证的疗效。方法：选取2023年7月~2023年12月在福建中医药大学附属第二人民医院呼吸科或治未病科门诊就诊的肺结节气虚痰瘀证患者60例，按随机数字表法分为对照组和治疗组各30例，治疗过程中对照组脱落2例，治疗组脱落1例。对照组予健康宣教，治疗组在对照组基础上加用益气散结颗粒口服，2组疗程均为12周。比较2组疗效及治疗前后胸部CT显示肺结节体积、血清血T淋巴细胞亚群指标(CD3 、CD4 、CD4 /CD8 水平)。结果：治疗组总有效率为93.1%，优于对照组的21.43% (P < 0.05)；治疗组治疗后肺结节体积小于治疗前(P < 0.05)，对照组治疗前后肺结节体积相当(P > 0.05)，治疗后治疗组肺结节体积小于对照组(P < 0.05)；治疗组治疗后血清CD3 、CD4 、CD4 /CD8 水平均高于治疗前(P < 0.05)，对照组治疗前后血清CD3 、CD4 、CD4 /CD8 水平相当(P > 0.05)，治疗后治疗组血清CD3 、CD4 、CD4 /CD8 水平均高于对照组(P < 0.05)。结论：益气散结颗粒治疗肺结节可有效改善中医症状，提高患者免疫功能，延缓肺结节进展，促进肺结节消散吸收，具有较高的临床推广价值。

Abstract: Objective: To observe the efficacy of Yiqi Sanjie Granules in the treatment of pulmonary nodules with Qi deficiency and phlegm stasis syndrome. Methods: 60 patients with pulmonary nodule syndrome of Qi deficiency and phlegm stasis who were treated in the Outpatient Department of the Respiratory Department or the Treatment and Prevention Department of the Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from July 2023 to December 2023 were selected and divided into controls according to the random number table method. There were 30 cases in each group and 30 cases in the treatment group. During the treatment process, 2 cases dropped out in the control group and 1 case dropped out in the treatment group. The control group received health education, while the treatment group received oral administration of Yiqi Sanjie Granules on the basis of the control group. The treatment course for both groups was 12 weeks. Compare the curative effects of the two groups and compare the lung nodule volume and serum T lymphocyte subgroup indicators (CD3 , CD4 , CD4 /CD8 levels) on chest CT before and after treatment. Results: The total effective rate of the treatment group was 93.1%, which was better than the 21.43% of the control group (P < 0.05); the volume of pulmonary nodules in the treatment group was smaller than before treatment (P < 0.05), and the volume of pulmonary nodules in the control group was similar before and after treatment (P > 0.05), the volume of pulmonary nodules in the treatment group was smaller than that in the control group after treatment (P < 0.05); the serum CD3 , CD4 , CD4 /CD8 levels in the treatment group after treatment were all higher than before treatment (P < 0.05), and in the control group before and after treatment, the serum CD3 , CD4 , CD4 /CD8 levels were comparable (P > 0.05). After treatment, the serum CD3 , CD4 , CD4 /CD8 levels in the treatment group were higher than those in the control group (P < 0.05). Conclusion: Yiqi Sanjie Granules can effectively improve TCM symptoms, improve patients’ immune function, delay the progression of pulmonary nodules, and promote the dissipation and absorption of pulmonary nodules, which has high clinical promotion value.