近红外荧光成像在泌尿系肿瘤中的研究进展
Research Progress on Specific Imaging of NIR-II Fluorescence Imaging in Urological Tumors
DOI: 10.12677/acm.2024.143891, PDF,    科研立项经费支持
作者: 达尼亚尔·努尔德别克, 阿卜杜热合曼·则比布拉, 乔炳璋, 木拉提·热夏提*：新疆医科大学第一临床医学院泌尿外科，新疆 乌鲁木齐
关键词: 近红外；荧光成像；泌尿系肿瘤；肿瘤成像；Near Infrared Region； Fluorescence Imaging； Urinary System Tumors； Tumor Imaging
摘要: 恶性肿瘤严重威胁着人类的生命健康，其中泌尿系三大肿瘤的发病率和死亡率也在不断上升，早期诊断、早期治疗可以显著改善肿瘤患者的预后。荧光成像(fluorescence imaging, FLI)可以进行实时、无创、高时空分辨率的成像，准确获取体内动态生物信息，对癌症的早期诊断和治疗具有重要作用。得益于近红外波段(Near-infrared, NIR)较强的穿透能力，有利于实现大的提高成像深度和高空间分辨率，突破了组织深部的成像限制。目前，荧光成像技术已用于肿瘤的特异性成像、手术辅助导航和光热治疗中，因此本文就NIR荧光成像在泌尿系肿瘤中特异性显像的研究进展作一综述。
Abstract: Malignant tumors pose a serious threat to human life and health, among which the incidence rate and mortality of the three major tumors of the urinary system are also rising. Early diagnosis and early treatment can significantly improve the prognosis of tumor patients. Fluorescence imaging (FLI) can provide real-time, non-invasive, and high spatiotemporal resolution imaging, accurately obtaining dynamic biological information in the body, and plays an important role in the early diagnosis and treatment of cancer. Thanks to the strong penetration ability of the Near infrared (NIR) band, it is conducive to achieving significant improvements in imaging depth and high spatial resolution, breaking through the imaging limitations of deep tissues. At present, fluorescence imaging technology has been used in tumor specific imaging, surgical assisted navigation, and photothermal therapy. Therefore, this article reviews the research progress of NIR fluorescence imaging in specific imaging of urinary system tumors.
文章引用：达尼亚尔·努尔德别克, 阿卜杜热合曼·则比布拉, 乔炳璋, 木拉提·热夏提. 近红外荧光成像在泌尿系肿瘤中的研究进展[J]. 临床医学进展, 2024, 14(3): 1659-1665. https://doi.org/10.12677/acm.2024.143891

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A. and Bray, F. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A. (2018) Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. [Google Scholar] [CrossRef] [PubMed]
[3] Xia, C., Dong, X., Li, H., Cao, M., Sun, D., He, S., Yang, F., Yan, X., Zhang, S., Li, N. and Chen, W. (2022) Cancer Statistics in China and United States, 2022: Profiles, Trends, and Determinants. Chinese Medical Journal, 135, 584-590. [Google Scholar] [CrossRef] 
[4] Schouw, H.M., Huisman, L.A., Janssen, Y.F., Slart, R.H.J.A., Borra, R.J.H., Willemsen, A.T.M., Brouwers, A.H., Van Dijl, J.M., Dierckx, R.A., Van Dam, G.M., Szymanski, W., Boersma, H.H. and Kruijff, S. (2021) Targeted Optical Fluorescence Imaging: A Meta-Narrative Review and Future Perspectives. European Journal of Nuclear Medicine and Molecular Imaging, 48, 4272-4292. [Google Scholar] [CrossRef] [PubMed]
[5] Shou, K., Qu, C., Sun, Y., Chen, H., Chen, S., Zhang, L., Xu, H., Hong, X., Yu, A. and Cheng, Z. (2017) Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR-II Probe. Advanced Functional Materials, 27, Article ID: 1700995. [Google Scholar] [CrossRef] [PubMed]
[6] Ito, R., Kamiya, M. and Urano, Y. (2022) Molecular Probes for Fluorescence Image-Guided Cancer Surgery. Current Opinion in Chemical Biology, 67, Article ID: 102112. [Google Scholar] [CrossRef] [PubMed]
[7] Li, D., Liu, Q., Qi, Q., Shi, H., Hsu, E.C., Chen, W., Yuan, W., Wu, Y., Lin, S., Zeng, Y., Xiao, Z., Xu, L., Zhang, Y., Stoyanova, T., Jia, W. and Cheng, Z. (2020) Gold Nanoclusters for NIR-II Fluorescence Imaging of Bones. Small, 16, e2003851. [Google Scholar] [CrossRef] 
[8] Qi, J., Sun, C., Li, D., Zhang, H., Yu, W., Zebibula, A., Lam, J.W.Y., Xi, W., Zhu, L., Cai, F., Wei, P., Zhu, C., Kwok, R.T.K., Streich, L.L., Prevedel, R., Qian, J. and Tang, B. Z. (2018) Aggregation-Induced Emission Luminogen with Near-Infrared-II Excitation and Near-Infrared-I Emission for Ultradeep Intravital Two-Photon Microscopy. ACS Nano, 12, 7936-7945. [Google Scholar] [CrossRef] [PubMed]
[9] Tang, Y., Li, Y., Hu, X., Zhao, H., Ji, Y., Chen, L., Hu, W., Zhang, W., Li, X., Lu, X., Huang, W. and Fan, Q. (2018) “Dual Lock-and-Key”-Controlled Nanoprobes for Ultrahigh Specific Fluorescence Imaging in the Second Near-Infrared Window. Advanced Materials, 30, e1801140. [Google Scholar] [CrossRef] [PubMed]
[10] Carr, J.A., Franke, D., Caram, J.R., Perkinson, C.F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R.K., Bawendi, M.G. and Bruns, O.T. (2018) Shortwave Infrared Fluorescence Imaging with the Clinically Approved Near-Infrared Dye Indocyanine Green. Proceedings of the National Academy of Sciences of the United States of America, 115, 4465-4470. [Google Scholar] [CrossRef] [PubMed]
[11] Siegel, R.L., Miller, K.D., Fuchs, H.E. and Jemal, A. (2022) Cancer Statistics, 2022. CA: A Cancer Journal for Clinicians, 72, 7-33. [Google Scholar] [CrossRef] [PubMed]
[12] Zhang, Q., Huang, R., Hu, H., Yu, L., Tang, Q., Tao, Y., Liu, Z., Li, J. and Wang, G. (2020) Integrative Analysis of Hypoxia-Associated Signature in Pan-Cancer. iScience, 23, Article ID: 101460. [Google Scholar] [CrossRef] [PubMed]
[13] 张伟, 屈志义, 刘晓阳, 等. 近红外荧光染料IR-780在肾透明细胞癌中的成像特征[J]. 中国组织工程研究, 2018, 22(28): 4532-4536.
[14] Yao, C., Chen, Y., Zhao, M., Wang, S., Wu, B., Yang, Y., Yin, D., Yu, P., Zhang, H. and Zhang, F. (2022) A Bright, Renal-Clearable NIR-II Brush Macromolecular Probe with Long Blood Circulation Time for Kidney Disease Bioimaging. Angewandte Chemie, 61, e202114273. [Google Scholar] [CrossRef] [PubMed]
[15] Qu, S., Jia, Q., Li, Z., Wang, Z. and Shang, L. (2022) Chiral NIR-II Fluorescent Ag2S Quantum Dots with Stereospecific Biological Interactions and Tumor Accumulation Behaviors. Science Bulletin, 67, 1274-1283. [Google Scholar] [CrossRef] [PubMed]
[16] Du, B., Chong, Y., Jiang, X., Yu, M., Lo, U.G., Dang, A., Chen, Y.A., Li, S., Hernandez, E., Lin, J.C., Hsieh, J.T. and Zheng, J. (2021) Hyperfluorescence Imaging of Kidney Cancer Enabled by Renal Secretion Pathway Dependent Efflux Transport. Angewandte Chemie, 60, 351-359. [Google Scholar] [CrossRef] [PubMed]
[17] Lin, T., Zhao, X., Zhao, S., Yu, H., Cao, W., Chen, W., Wei, H. and Guo, H. (2018) O2-Generating MnO2 Nanoparticles for Enhanced Photodynamic Therapy of Bladder Cancer by Ameliorating Hypoxia. Theranostics, 8, 990-1004. [Google Scholar] [CrossRef] [PubMed]
[18] Ren, S., Dai, R., Zheng, Z., Liu, Q., Zheng, X., Li, J., Wu, S., Zhang, R. and Gui, Z. (2023) A Novel Bidirectional Perfusion-Like Administered System for NIR-II Fluorescence Imaging Precision Diagnosis of Bladder Cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 49, Article ID: 102661. [Google Scholar] [CrossRef] [PubMed]
[19] Alifu, N., Zebibula, A., Qi, J., Zhang, H., Sun, C., Yu, X., Xue, D., Lam, J.W.Y., Li, G., Qian, J. and Tang, B.Z. (2022) Correction to “Single-Molecular Near-Infrared-II Theranostic Systems: Ultrastable Aggregation-Induced Emission Nanoparticles for Long-Term Tracing and Efficient Photothermal Therapy”. ACS Nano, 16, 9961. [Google Scholar] [CrossRef] [PubMed]
[20] Huang, J., Jiang, Y., Li, J., He, S., Huang, J. and Pu, K. (2020) A Renal-Clearable Macromolecular Reporter for Near-Infrared Fluorescence Imaging of Bladder Cancer. Angewandte Chemie, 59, 4415-4420. [Google Scholar] [CrossRef] [PubMed]
[21] Hao, H., Wang, X., Qin, Y., Ma, Z., Yan, P., Liu, C., Chen, G. and Yang, X. (2023) Ex Vivo Near-Infrared Targeted Imaging of Human Bladder Carcinoma by ICG-Anti-CD47. Frontiers in Oncology, 13, Article 1083553. [Google Scholar] [CrossRef] [PubMed]
[22] Asha Krishnan, M., Yadav, K., Roach, P., and Chelvam, V. (2021) A Targeted Near-Infrared Nanoprobe for Deep-Tissue Penetration and Imaging of Prostate Cancer. Biomaterials Science, 9, 2295-2312. [Google Scholar] [CrossRef] 
[23] Fujimura, T., Takayama, K., Takahashi, S. and Inoue, S. (2018) Estrogen and Androgen Blockade for Advanced Prostate Cancer in the Era of Precision Medicine. Cancers, 10, Article 29. [Google Scholar] [CrossRef] [PubMed]
[24] Thelen, P., Wuttke, W. and Seidlová-Wuttke, D. (2014) Phytoestrogens Selective for the Estrogen Receptor β Exert Anti-Androgenic Effects in Castration Resistant Prostate Cancer. The Journal of Steroid Biochemistry and Molecular Biology, 139, 290-293. [Google Scholar] [CrossRef] [PubMed]
[25] Lucky, S.S., Soo, K.C. and Zhang, Y. (2015) Nanoparticles in Photodynamic Therapy. Chemical Reviews, 115, 1990-2042. [Google Scholar] [CrossRef] [PubMed]
[26] Zhou, Z., Zhang, L., Zhang, Z. and Liu, Z. (2021) Advances in Photosensitizer-Related Design for Photodynamic Therapy. Asian Journal of Pharmaceutical Sciences, 16, 668-686. [Google Scholar] [CrossRef] [PubMed]
[27] Zhou, J., Jiang, Y., Hou, S., Upputuri, P.K., Wu, D., Li, J., Wang, P., Zhen, X., Pramanik, M., Pu, K. and Duan, H. (2018) Compact Plasmonic Blackbody for Cancer Theranosis in the Near-Infrared II Window. ACS Nano, 12, 2643-2651. [Google Scholar] [CrossRef] [PubMed]
[28] Sun, Z., Zhang, W., Ye, Z., Yuan, L., Fu, M., Liu, X., Liang, H. and Han, H. (2022) NIR-II-Triggered Doxorubicin Release for Orthotopic Bladder Cancer Chemo-Photothermal Therapy. Nanoscale, 14, 17929-17939. [Google Scholar] [CrossRef] 
[29] Chen, Q.Y., Xie, J.W., Zhong, Q., Wang, J.B., Lin, J.X., Lu, J., Cao, L.L., Lin, M., Tu, R.H., Huang, Z.N., Lin, J.L., Zheng, H.L., Li, P., Zheng, C.H. and Huang, C.M. (2020) Safety and Efficacy of Indocyanine Green Tracer-Guided Lymph Node Dissection during Laparoscopic Radical Gastrectomy in Patients with Gastric Cancer: A Randomized Clinical Trial. JAMA Surgery, 155, 300-311. [Google Scholar] [CrossRef] [PubMed]
[30] Inagaki, F.F., Wakiyama, H., Furusawa, A., Okada, R., Kato, T., Fujimura, D., Okuyama, S., Fukushima, H., Takao, S., Choyke, P.L. and Kobayashi, H. (2023) Near-Infrared Photoimmunotherapy (NIR-PIT) of Bone Metastases. Biomedicine & Pharmacotherapy, 160, Article ID: 114390. [Google Scholar] [CrossRef] [PubMed]
[31] Tobis, S., Knopf, J.K., Silvers, C., Messing, E., Yao, J., Rashid, H., Wu, G. and Golijanin, D. (2012) Robot-Assisted and Laparoscopic Partial Nephrectomy with Near Infrared Fluorescence Imaging. Journal of Endourology, 26, 797-802. [Google Scholar] [CrossRef] [PubMed]
[32] Krane, L.S., Manny, T.B. and Hemal, A.K. (2012) Is Near Infrared Fluorescence Imaging Using Indocyanine Green Dye Useful in Robotic Partial Nephrectomy: A Prospective Comparative Study of 94 Patients. Urology, 80, 110-116. [Google Scholar] [CrossRef] [PubMed]
[33] Bjurlin, M.A., McClintock, T.R. and Stifelman, M.D. (2015) Near-Infrared Fluorescence Imaging with Intraoperative Administration of Indocyanine Green for Robotic Partial Nephrectomy. Current Urology Reports, 16, Article No. 20. [Google Scholar] [CrossRef] [PubMed]
[34] Cao, C., Deng, S., Wang, B., Shi, X., Ge, L., Qiu, M., Zhang, F., Lu, M., Ma, L., Chi, C., Hu, Z., Tian, J. and Zhang, S. (2021) Intraoperative Near-Infrared II Window Fluorescence Imaging-Assisted Nephron-Sparing Surgery for Complete Resection of Cystic Renal Masses. Clinical and Translational Medicine, 11, e604. [Google Scholar] [CrossRef] [PubMed]
[35] Van Der Poel, H.G., Buckle, T., Brouwer, O.R., ValdéS Olmos, R.A. and Van Leeuwen, F.W. (2011) Intraoperative Laparoscopic Fluorescence Guidance to the Sentinel Lymph Node in Prostate Cancer Patients: Clinical Proof of Concept of an Integrated Functional Imaging Approach Using a Multimodal Tracer. European Urology, 60, 826-833. [Google Scholar] [CrossRef] [PubMed]
[36] Kaplan-Marans, E., Fulla, J., Tomer, N., Bilal, K. and Palese, M. (2019) Indocyanine Green (ICG) in Urologic Surgery. Urology, 132, 10-17. [Google Scholar] [CrossRef] [PubMed]
[37] Manny, T.B., Patel, M. and Hemal, A.K. (2014) Fluorescence-Enhanced Robotic Radical Prostatectomy Using Real-Time Lymphangiography and Tissue Marking with Percutaneous Injection of Unconjugated Indocyanine Green: The Initial Clinical Experience in 50 Patients. European Urology, 65, 1162-1168. [Google Scholar] [CrossRef] [PubMed]
[38] Inoue, S., Shiina, H., Mitsui, Y., Yasumoto, H., Matsubara, A. and Igawa, M. (2013) Identification of Lymphatic Pathway Involved in the Spread of Bladder Cancer: Evidence Obtained From Fluorescence Navigation with Intraoperatively Injected Indocyanine Green. Canadian Urological Association Journal, 7, e322-e328. [Google Scholar] [CrossRef] 
[39] Manny, T.B., Pompeo, A.S. and Hemal, A.K. (2013) Robotic Partial Adrenalectomy Using Indocyanine Green Dye with Near-Infrared Imaging: The Initial Clinical Experience. Urology, 82, 738-742. [Google Scholar] [CrossRef] [PubMed]
[40] Esposito, C., Borgogni, R., Autorino, G., Cerulo, M., Carulli, R., Esposito, G., Del Conte, F. and Escolino, M. (2022) Applications of Indocyanine Green-Guided Near-Infrared Fluorescence Imaging in Pediatric Minimally Invasive Surgery Urology: A Narrative Review. Journal of Laparoendoscopic & Advanced Surgical Techniques, 32, 1280-1287. [Google Scholar] [CrossRef] [PubMed]

为你推荐