降脂药物对认知功能影响的综述与前瞻
A Comprehensive Review and Prospects on the Impact of Lipid-Lowering Drugs on Cognitive Functions
DOI: 10.12677/acm.2024.143894, PDF,   
作者: 韩立君, 高 聆*:山东大学附属省立医院内分泌代谢病科,山东 济南;苏 畅:山东第一医科大学附属省立医院内分泌代谢病科,山东 济南
关键词: 降脂药他汀依折麦布PCSK9抑制剂认知表现Lipid-Lowering Drugs Statins Ezetimibe PSCK9 Inhibitors Cognitive Performance
摘要: 本综述探讨了降脂药物(包括他汀类、PCSK9抑制剂、依折麦布和贝特类)对认知功能的潜在影响。尽管有些研究和病例报告提示这些药物可能对认知有不良影响,大型随机对照试验通常未发现明确的关联。文章强调了在临床实践中对特定患者群体采取谨慎的治疗策略的重要性,并建议进行更多研究来深入理解降脂药物与认知功能之间的关系。未来研究需关注长期影响和潜在机制,以为心血管疾病患者提供全面的健康管理策略。
Abstract: This review examines the potential cognitive effects of lipid-lowering medications, including statins, PCSK9 inhibitors, ezetimibe, and fibrates. While some studies and case reports suggest adverse cognitive effects associated with these drugs, large-scale randomized controlled trials generally do not establish a clear link. The article emphasizes the importance of cautious treatment strategies in clinical practice, especially for specific patient groups, and calls for further research to better understand the relationship between lipid-lowering medications and cognitive function. Future research should focus on long-term effects and underlying mechanisms to provide comprehensive health management strategies for patients with cardiovascular diseases.
文章引用:韩立君, 苏畅, 高聆. 降脂药物对认知功能影响的综述与前瞻[J]. 临床医学进展, 2024, 14(3): 1683-1690. https://doi.org/10.12677/acm.2024.143894

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