miRNA与小细胞肺癌关系的研究进展
Advances in the Relationship between miRNA and Small Cell Lung Cancer
DOI: 10.12677/acm.2024.143897, PDF,   
作者: 郑 杨, 帕提古力·阿尔西丁*：新疆医科大学附属肿瘤医院肺内科一病区，新疆 乌鲁木齐
关键词: 微小RNA；小细胞肺癌；转移；耐药；预后；MicroRNA； Small Cell Lung Cancer； Metastasis； Drug Resistance； Prognosis
摘要: 小细胞肺癌(Small Cell Lung Cancer, SCLC)是一种恶性程度高的神经内分泌肿瘤，其病情进展快，短期内易出现耐药或复发，预后很差。微小RNA (microRNA, miRNA)是一类由19~25个核苷酸组成的非编码单链RNA，广泛分布于真核生物中，参与多种疾病的发生过程。有研究显示，miRNA在SCLC中表达失调，发挥抑癌或促癌作用，参与SCLC的增殖、侵袭、转移及耐药的生物学过程。同时，也有报道，miRNA作为SCLC的诊断及预后的生物标志物提供了可能性。本文就miRNA在SCLC的增殖转移、耐药、诊断、预后等相关的研究进展作一综述。
Abstract: Small cell lung cancer (SCLC) is a highly malignant neuroendocrine tumor with rapid progression, short-term susceptibility to drug resistance or recurrence, and poor prognosis. MicroRNA (miRNA) is a class of non-coding single-stranded RNAs consisting of 19~25 nucleotides, which are widely distributed in eukaryotes and are involved in the process of many diseases. Some studies have shown that miRNAs are dysregulated in SCLC expression, exert oncogenic or pro-oncogenic effects, and participate in the biological processes of proliferation, invasion, metastasis, and drug resistance in SCLC. Meanwhile, it has also been reported that miRNAs offer possibilities as biomarkers for the diagnosis and prognosis of SCLC. In this paper, we present a review of the research progress of miRNAs related to proliferation and metastasis, drug resistance, diagnosis and prognosis of SCLC.
文章引用：郑杨, 帕提古力·阿尔西丁. miRNA与小细胞肺癌关系的研究进展[J]. 临床医学进展, 2024, 14(3): 1704-1709. https://doi.org/10.12677/acm.2024.143897

参考文献

[1] Liu, X., Xing, H. and Liu, B. (2022) Current Status and Future Perspectives of Immune Checkpoint Inhibitors in Extensive-Stage Small Cell Lung Cancer. American Journal of Cancer Research, 12, 2447-2464.
[2] Guo, H., Li, L. and Cui, J. (2020) Advances and Challenges in Immunotherapy of Small Cell Lung Cancer. Chinese Journal of Cancer Research, 32, 115-128. [Google Scholar] [CrossRef] [PubMed]
[3] Yang, S., Zhang, Z. and Wang, Q. (2019) Emerging Therapies for Small Cell Lung Cancer. Journal of Hematology & Oncology, 12, Article No. 47. [Google Scholar] [CrossRef] [PubMed]
[4] Yang, H., Liu, Y., Chen, L., et al. (2023) miRNA-Based Therapies for Lung Cancer: Opportunities and Challenges? Biomolecules, 13, Article 877. [Google Scholar] [CrossRef] [PubMed]
[5] Lei, Y., Chen, L., Liu, J., et al. (2022) The MicroRNA-Based Strategies to Combat Cancer Chemoresistance via Regulating Autophagy. Frontiers in Oncology, 12, Article 841625. [Google Scholar] [CrossRef] [PubMed]
[6] Wani, J.A., Majid, S., Imtiyaz, Z., et al. (2022) MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential. Diagnostics (Basel), 12, Article 1610. [Google Scholar] [CrossRef] [PubMed]
[7] Pandey, M., Mukhopadhyay, A., Sharawat, S.K., et al. (2021) Role of MicroRNAs in Regulating Cell Proliferation, Metastasis and Chemoresistance and Their Applications as Cancer Biomarkers in Small Cell Lung Cancer. Biochimica et Biophysica Acta, 1876, Article 188552. [Google Scholar] [CrossRef] [PubMed]
[8] Rajgor, D., Sanderson, T.M., Amici, M., et al. (2018) NMDAR-Dependent Argonaute 2 Phosphorylation Regulates miRNA Activity and Dendritic Spine Plasticity. The EMBO Journal, 37, e97943. [Google Scholar] [CrossRef] [PubMed]
[9] Hutvagner, G., McLachlan, J., Pasquinelli, A.E., et al. (2001) A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the Let-7 Small Temporal RNA. Science, 293, 834-838. [Google Scholar] [CrossRef] [PubMed]
[10] Sell, M.C., Ramlogan-Steel, C.A., Steel, J.C., et al. (2023) MicroRNAs in Cancer Metastasis: Biological and Therapeutic Implications. Expert Reviews in Molecular Medicine, 25, e14. [Google Scholar] [CrossRef] [PubMed]
[11] Liu, Z.L., Wang, H., Liu, J., et al. (2013) MicroRNA-21 (miR-21) Expression Promotes Growth, Metastasis, and Chemo-or Radioresistance in Non-Small Cell Lung Cancer Cells by Targeting PTEN. Molecular and Cellular Biochemistry, 372, 35-45. [Google Scholar] [CrossRef] [PubMed]
[12] Takamizawa, J., Konishi, H., Yanagisawa, K., et al. (2004) Reduced Expression of the Let-7 MicroRNAs in Human Lung Cancers in Association with Shortened Postoperative Survival. Cancer Research, 64, 3753-3756. [Google Scholar] [CrossRef] 
[13] Zhao, B., Han, H., Chen, J., et al. (2014) MicroRNA Let-7c Inhibits Migration and Invasion of Human Non-Small Cell Lung Cancer by Targeting ITGB3 and MAP4K3. Cancer Letters, 342, 43-51. [Google Scholar] [CrossRef] [PubMed]
[14] Liu, J., Liu, S., Deng, X., et al. (2019) MicroRNA-582-5p Suppresses Non-Small Cell Lung Cancer Cells Growth and Invasion via Downregulating NOTCH1. PLOS ONE, 14, e217652. [Google Scholar] [CrossRef] [PubMed]
[15] Li, L., Song, W., Yan, X., et al. (2017) Friend Leukemia Virus Integration 1 Promotes Tumorigenesis of Small Cell Lung Cancer Cells by Activating the miR-17-92 Pathway. Oncotarget, 8, 41975-41987. [Google Scholar] [CrossRef] [PubMed]
[16] Zhou, R., Zhou, X., Yin, Z., et al. (2015) Tumor Invasion and Metastasis Regulated by MicroRNA-184 and MicroRNA-574-5p in Small-Cell Lung Cancer. Oncotarget, 6, 44609-44622. [Google Scholar] [CrossRef] [PubMed]
[17] Gao, F., Wu, H., Wang, R., et al. (2019) MicroRNA-485-5p Suppresses the Proliferation, Migration and Invasion of Small Cell Lung Cancer Cells by Targeting Flotillin-2. Bioengineered, 10, 1-12. [Google Scholar] [CrossRef] [PubMed]
[18] Cao, J., Song, Y., Bi, N., et al. (2013) DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer. Cancer Research, 73, 3326-3335. [Google Scholar] [CrossRef] 
[19] Khan, P., Siddiqui, J.A., Kshirsagar, P.G., et al. (2023) MicroRNA-1 Attenuates the Growth and Metastasis of Small Cell Lung Cancer through CXCR4/FOXM1/RRM2 Axis. Molecular Cancer, 22, Article No. 1. [Google Scholar] [CrossRef] [PubMed]
[20] Mao, S., Lu, Z., Zheng, S., et al. (2020) Exosomal miR-141 Promotes Tumor Angiogenesis via KLF12 in Small Cell Lung Cancer. Journal of Experimental & Clinical Cancer Research, 39, Article No. 193. [Google Scholar] [CrossRef] [PubMed]
[21] Zhao, Z., Liu, J., Wang, C., et al. (2014) MicroRNA-25 Regulates Small Cell Lung Cancer Cell Development and Cell Cycle through Cyclin E2. International Journal of Clinical and Experimental Pathology, 7, 7726-7734.
[22] Sun, Y., Hu, B., Wang, Y., et al. (2018) miR-216a-5p Inhibits Malignant Progression in Small Cell Lung Cancer: Involvement of the Bcl-2 Family Proteins. Cancer Management and Research, 10, 4735-4745. [Google Scholar] [CrossRef] 
[23] Liu, H., Wu, X., Huang, J., et al. (2015) miR-7 Modulates Chemoresistance of Small Cell Lung Cancer by Repressing MRP1/ABCC1. International Journal of Experimental Pathology, 96, 240-247. [Google Scholar] [CrossRef] [PubMed]
[24] Liu, H., Huang, J., Peng, J., et al. (2015) Upregulation of the Inwardly Rectifying Potassium Channel Kir2. 1 (KCNJ2) Modulates Multidrug Resistance of Small-Cell Lung Cancer under the Regulation of miR-7 and the Ras/MAPK Pathway. Molecular Cancer, 14, Article No. 59. [Google Scholar] [CrossRef] [PubMed]
[25] Cui, F., Hao, Z.X., Li, J., et al. (2020) SOX2 Mediates Cisplatin Resistance in Small-Cell Lung Cancer with Downregulated Expression of hsa-miR-340-5p. Molecular Genetics & Genomic Medicine, 8, e1195. [Google Scholar] [CrossRef] [PubMed]
[26] Lai, J., Yang, H., Zhu, Y., et al. (2019) miR-7-5p-Mediated Downregulation of PARP1 Impacts DNA Homologous Recombination Repair and Resistance to Doxorubicin in Small Cell Lung Cancer. BMC Cancer, 19, Article No. 602. [Google Scholar] [CrossRef] [PubMed]
[27] Yang, X., Bai, F., Xu, Y., et al. (2017) Intensified Beclin-1 Mediated by Low Expression of miR-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer. Cellular Physiology and Biochemistry, 43, 1126-1139. [Google Scholar] [CrossRef] [PubMed]
[28] Pan, B., Chen, Y., Song, H., et al. (2015) miR-24-3p Downregulation Contributes to VP16-DDP Resistance in Small-Cell Lung Cancer by Targeting ATG4A. Oncotarget, 6, 317-331. [Google Scholar] [CrossRef] [PubMed]
[29] Yu, Y., Zuo, J., Tan, Q., et al. (2017) Plasma miR-92a-2 as a Biomarker for Small Cell Lung Cancer. Cancer Biomarkers, 18, 319-327. [Google Scholar] [CrossRef] 
[30] Yan, H., Xin, S., Ma, J., et al. (2019) A Three MicroRNA-Based Prognostic Signature for Small Cell Lung Cancer Overall Survival. Journal of Cellular Biochemistry, 120, 8723-8730. [Google Scholar] [CrossRef] [PubMed]

为你推荐