子午流注开穴法联合干扰素治疗持续性宫颈HR-HPV感染的临床研究

Clinical Study on the Treatment of Persistent Cervical HR-HPV Infection by Point Opening by Meridian Stream Injection Combined with Interferon

摘要: 目的：本项目基于病例–对照研究设计，通过中西医结合的方法提高持续HR-HPV感染的转阴率，从而降低宫颈癌的发病率，为临床治疗持续性宫颈HR-HPV感染提供新的中西医疗法和理论依据。方法：收集2021年10月至2022年12月于我院妇科门诊就诊的宫颈HR-HPV感染患者，且参照诊断标准，选择符合纳入标准的病人共计60人；将60例患者随机分为试验组(n = 30)及对照组(n = 30)，对试验组患者进行子午流注开穴法联合重组人干扰素α2b阴道泡腾片治疗进行治疗，对照组患者给予重组人干扰素α2b阴道泡腾片治疗，分别比较两组患者HPV转阴率、中医证候及阴道微生态的改善情况。结果：治疗后两组患者的HPV转阴率、中医证候及阴道微生态均比治疗前有所提高。1) 治疗后试验组30例中有21例转阴，转阴率为70%，对照组30例中11例转阴，HPV转阴率为36.67%，两组HPV转阴率的比较有显著统计学差异(P < 0.01)试验组优于对照组；2) 两组中医证候评分进行配对T检验，P < 0.01，有统计学意义，试验组改善中医证候方面较为显著。3) 两组阴道微生态各项指标均有改善，试验组的白细胞酯酶、乙酰氨基葡萄糖苷酶及PH值改善优于对照组，差异具有统计学意义(P < 0.05)。4) 试验组临床总有效率为90%，对照组临床总有效率60%，两组差异有统计学意义(P < 0.001)。结论：子午流注开穴法联合干扰素治疗宫颈HR-HPV感染，临床疗效确切，该法与单纯西药治疗相比较，能明显改善患者的阴道微生态及中医证候，提高HR-HPV转阴率，其安全可靠，建议推广应用。

Abstract: Objective: Based on the case-control study design, this project aims to improve the negative conversion rate of persistent HR-HPV infection by combining traditional Chinese and western medicine, thus reducing the incidence of cervical cancer and providing new Chinese and western medicine therapy and theoretical basis for clinical treatment of persistent cervical HR-HPV infection. Methods: From October 2021 to December 2022, 60 patients with cervical HR-HPV infection who visited the gynecological clinic in our hospital were selected according to the diagnostic criteria. 60 patients were randomly divided into the experimental group (n = 30) and the control group (n = 30). The patients in the experimental group were treated with point opening by meridian stream injection combined with recombinant human interferon α2b vaginal effervescent tablets, while the patients in the control group were treated with recombinant human interferon α2b vaginal effervescent tablets. The HPV negative rate, TCM syndromes and the improvement of vaginal microecology were compared between the two groups. Results: After treatment, the HPV negative rate, TCM syndromes and vaginal microecology of the two groups were improved compared with those before treatment. 1) After treatment, 21 of the 30 cases in the experimental group turned negative, with a negative rate of 70%, while 11 of the 30 cases in the control group turned negative, with an HPV negative rate of 36.67%. There was a significant statistical difference between the two groups (P < 0.01). 2) Paired T-test was conducted for the scores of TCM syndromes in the two groups, with statistical significance (P < 0.01), and the improvement of TCM syndromes in the experimental group was more significant. 3) The indicators of vaginal microecology were improved in both groups. The leukocyte esterase, acetylglucosaminidase and PH value in the experimental group were better than those in the control group, and the difference was statistically significant (P < 0.05). 4) The total clinical effective rate of the experimental group was 90%, while that of the control group was 60%, with statistical significance (P < 0.001). Conclusion: point opening by meridian stream injection combined with interferon in the treatment of cervical HR-HPV infection has definite clinical effect. Compared with simple western medicine treatment, this method can obviously improve the vaginal microecology and TCM syndromes of patients and increase the negative rate of HR-HPV. It is safe and reliable, and it is recommended to be popularized and applied.