AGTR1 (A1166C)基因多态性与脑梗死预后的相关性分析

Correlation Analysis of AGTR1 (A1166C) Gene Polymorphism and Prognosis of Cerebral Infarction

摘要: 目的：探究血管紧张素II-1型受体(AGTR1) (A1166C)基因多态性与脑梗死风险因素及预后相关性，为进一步推动脑梗死的二级预防以及治疗提供依据。方法：选取2021年4月至2021年8月期间就诊于北华大学附属医院神经内科首发症状性脑梗死患者50例(男性39例，女性患者11例)，平均年龄(66.6 ± 10.54)岁。以A1166C基因型进行分组：野生型组(AA)、突变组(AC CC)，收集患者一般资料、量表评分(NIHSS评分、Barthel指数)及疾病是否复发。结果：1) 单因素分析结果显示在年龄、症状首发年龄、出院时NIHSS评分、AGTR1 (A1166C)基因型比例比较，差异无统计学意义(P > 0.05)；2) 单因素分析示AGTR1 (A1166C)基因多态性均与脑梗死患者的严重程度、复发、Barthel指数具有相关性(P < 0.05)，差异有统计学意义；3) 多因素分析结果表明AGTR1 (A1166C)基因是脑梗死复发的独立危险因素，AC、CC基因型脑梗死患者的复发率是AA型的8.72倍，即AGTR1 (A1166C)基因突变时，脑梗死的复发率增高。结论：AGTR1 (A1166C)基因多态性与脑梗死的发生有关联，是脑梗死的独立危险因素。

Abstract: Objective: To explore the correlation between angiotensin II-1 receptor (AGTR1) (A1166C) gene polymorphism and risk factors and prognosis of cerebral infarction, and to provide evidence for further secondary prevention and treatment of cerebral infarction. Methods: A total of 50 patients (39 males and 11 females) with an average age of (66.6 ± 10.54) with first symptomatic cerebral infarction were selected from the Department of Neurology, Affiliated Hospital of North China University from April to August 2021. Genotype A1166C was divided into wild type group (AA) and mutant group (AC CC). General information, scale score (NIHSS score, Barthel index) and disease recurrence were collected. Results: 1) Univariate analysis showed no statistically significant differences in age, age at first symptom onset, NIHSS score at discharge, and proportion of AGTR1 (A1166C) genotypes (P > 0.05); 2) Univariate analysis showed that AGTR1 (A1166C) gene polymorphism was correlated with the severity, recurrence and Barthel index of patients with cerebral infarction (P < 0.05), and the difference was statistically significant. 3) Multivariate analysis showed that AGTR1 (A1166C) gene was an independent risk factor for cerebral infarction recurrence, and the recurrence rate of AC and CC genotype cerebral infarction patients was 8.72 times that of AA genotype cerebral infarction patients, that is, when AGTR1 (A1166C) gene mutation, the recurrence rate of cerebral infarction increased. Conclusion: AGTR1 (A1166C) gene polymorphism is associated with the occurrence of cerebral infarction and is an independent risk factor for cerebral infarction.