miR-485-3p在消化系统肿瘤中的研究进展

Research Progress of miR-485-3p in Digestive System Tumors

摘要: microRNAs (miRNAs)是一类在动物、植物、病毒进化上保守的非编码RNA，并已被证明通过转录后调节发挥作用，参与多种生物学过程。最近的研究表明，miRNAs可调节基因组不稳定性，尤其在许多癌症中，miRNA的表达失调会导致肿瘤异质性和耐药性的基因改变。因此，近几年来miRNA在肿瘤中的作用是研究热点之一，miR-485-3P便是其中之一。现有研究表明，miR-485-3P可通过调控PD-L1、JAK2、STAT3、MAT1A等明星分子来改变细胞凋亡、增殖、迁移等生物学功能，从而调控结直肠癌、肝细胞癌、胃癌、胰腺癌等恶性肿瘤进展，同时也参与了其他肿瘤的调控。在本篇综述中，我们主要概述了目前关于miR-485-3p在消化系统肿瘤中的调控机制的相关研究进展。期望我们的工作可以为上述肿瘤的进一步研究带来益处。

Abstract: microRNAs (miRNAs) are a class of non-coding RNAs that are conserved in the evolution of animals, plants, and viruses, and have been shown to play a role through post-transcriptional regulation and participate in a variety of biological processes. Recent studies have shown that miRNAs can regulate genomic instability, especially in many cancers, and dysregulation of miRNA expression can lead to genetic changes in tumor heterogeneity and drug resistance. Therefore, in recent years, the role of miRNAs in tumors has been one of the research hotspots, and miR-485-3P is one of them. Previous studies have shown that miR-485-3P can change the biological functions of apoptosis, proliferation and migration by regulating PD-L1, JAK2, STAT3, MAT1A and other star molecules, so as to regulate the progression of malignant tumors such as colorectal cancer, hepatocellular carcinoma, gastric cancer, pancreatic cancer, etc., and also participate in the regulation of other tumors. In this review, we mainly summarize the current research progress on the regulatory mechanism of miR-485-3p in digestive system tumors. It is expected that our work can bring benefits to the further study of the above tumors.