同步子宫内膜癌和卵巢癌1例并文献回顾
Synchronous Endometrial Cancer and Ovarian Cancer: A Case Report and Literature Review
摘要: 报道并分析青岛大学附属医院病理确诊的1例同步子宫内膜癌和卵巢癌(SEOC)患者的临床表现、病理特点及治疗方法。该例SEOC患者临床表现不典型，诊断主要依靠术前及术后病理。术后病理示：1) 子宫宫内膜样癌，侵达浅肌层(<1/2肌层)，未累及双侧宫旁组织，未累及宫颈管。2) 右侧卵巢宫内膜样癌。3) 右侧卵巢透明细胞癌(OCCC)。SEOC临床较少见，诊断主要依靠病理诊断，目前首选手术治疗，术后仍需要辅助治疗，密切随访。
Abstract: To report and analyze the clinical manifestations, pathological characteristics and treatment methods of a case of synchronous endometrial and ovarian carcinomas diagnosed by pathology in the Affiliated Hospital of Qingdao University, the clinical manifestations of this patient with synchronous endometrial and ovarian carcinomas are not typical, and the diagnosis mainly depends on preoperative and postoperative pathology. Postoperative pathology showed: 1) Endometrioid carcinoma of the uterus, invading superficial muscularis (<1/2 muscularis), not involving bilateral parametrial tissues, not involving cervical canal. 2) Right ovarian endometrioid carcinoma. 3) Clear cell carcinoma of the right ovary. Synchronous endometrial and ovarian carcinomas is rare in clinical practice, and its diagnosis mainly depends on pathological diagnosis. At present, surgical treatment is the first choice, and adjuvant treatment and close follow-up are still needed after surgery.
文章引用：刘思园, 王畅, 袁芳. 同步子宫内膜癌和卵巢癌1例并文献回顾[J]. 临床医学进展, 2024, 14(3): 2316-2321. https://doi.org/10.12677/acm.2024.143977

参考文献

[1] Gezer, Ş. and Bayrak, B.Y. (2021) Metastatic and Synchronous Ovarian Involvement in Low-Risk Endometrial Cancer; Clinicopathological Analysis with Detection of DNA Mismatch Repair Deficiency. Ginekologia Polska, 92, 599-606. [Google Scholar] [CrossRef] 
[2] Daley, D., et al. (2022) Case Report: Spontaneous Remission of Synchronous Endometrial and Ovarian Cancers Following Pregnancy. Frontiers in Oncology, 12, 489. [Google Scholar] [CrossRef] [PubMed]
[3] Shin, W., Park, S.-Y., Kang, S., Lim, M.C. and Seo, S.S. (2021) How to Manage Synchronous Endometrial and Ovarian Cancer Patients? BMC Cancer, 21, Article Number: 489. [Google Scholar] [CrossRef] [PubMed]
[4] Kobayashi, H. (2023) Clinicopathological Characteristics, Molecular Features and Novel Diagnostic Strategies for the Detection of Malignant Transformation of Endometriosis (Review). Experimental and Therapeutic Medicine, 25, Article Number: 279. [Google Scholar] [CrossRef] [PubMed]
[5] Fadare, O. and Parkash, V. (2019) Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary. Surgical Pathology Clinics, 12, 529-564. [Google Scholar] [CrossRef] [PubMed]
[6] Kobayashi, H., et al. (2019) Integrating Modern Approaches to Pathogenetic Concepts of Malignant Transformation of Endometriosis. Oncology Reports, 41, 1729-1738.
[7] Kato, N. (2020) Pathology of Clear Cell Carcinoma of the Ovary: A Basic View Based on Cultured Cells and Modern View from Comprehensive Approaches. Pathology International, 70, 591-601. [Google Scholar] [CrossRef] [PubMed]
[8] Shigetomi, H., Imanaka, S. and Kobayashi, H. (2021) Effects of Iron-Related Compounds and Bilirubin on Redox Homeostasis in Endometriosis and Its Malignant Transformations. Hormone Molecular Biology and Clinical Investigation, 43, 187-192. [Google Scholar] [CrossRef] [PubMed]
[9] Kohno, T. and Kojima, T. (2022) Atypical Macropinocytosis Contributes to Malignant Progression: A Review of Recent Evidence in Endometrioid Endometrial Cancer Cells. Cancers, 14, 5056. [Google Scholar] [CrossRef] [PubMed]
[10] Hsu Lin, L., et al. (2023) DNA Methylation Signature of Synchronous Endometrioid Endometrial and Ovarian Carcinomas. Modern Pathology, 36, Article ID 100321. [Google Scholar] [CrossRef] [PubMed]
[11] Moro, F., et al. (2019) Synchronous Primary Cancers of Endometrium and Ovary vs Endometrial Cancer with Ovarian Metastasis: An Observational Study. Ultrasound in Obstetrics & Gynecology, 53, 827-835. [Google Scholar] [CrossRef] [PubMed]
[12] Morioka, S., et al. (2019) Magnetic Resonance Imaging Findings for Discriminating Clear Cell Carcinoma and Endometrioid Carcinoma of the Ovary. Journal of Ovarian Research, 12, Article Number: 20. [Google Scholar] [CrossRef] [PubMed]
[13] Mikhaleva, L.M., et al. (2020) Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review. Advances in Therapy, 37, 2580-2603. [Google Scholar] [CrossRef] [PubMed]
[14] Hoorshad, N., et al. (2023) Synchronous Endometrial and Ovarian Cancer and Its Recurrent Risk Factors: Case Series. Cancer Treatment and Research Communications, 36, 100731. [Google Scholar] [CrossRef] [PubMed]
[15] Mikhaleva, L., et al. (2020) Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review. Advances in Therapy, 37, 2580-2603. [Google Scholar] [CrossRef] [PubMed]
[16] Žilovič, D., et al. (2023) Synchronous Endometrial and Ovarian Cancer: A Case Report. World Journal of Clinical Cases, 11, 4341-4349. [Google Scholar] [CrossRef] [PubMed]
[17] Khalid, N., et al. (2020) Synchronous Primary Endometrial and Ovarian Cancers: Trends and Outcomes of the Rare Disease at a South Asian Tertiary Care Cancer Center. Cureus, 12, e9163. [Google Scholar] [CrossRef] [PubMed]
[18] Gan, W.L. and Bian, C. (2023) The Research Progress on Synchronous Endometrial and Ovarian Carcinoma. Frontiers in Oncology, 13, 1291602. [Google Scholar] [CrossRef] [PubMed]
[19] Zhou, L., et al. (2021) Ovarian Endometrioid Carcinoma and Clear Cell Carcinoma: A 21-Year Retrospective Study. Journal of Ovarian Research, 14, Article Number: 63. [Google Scholar] [CrossRef] [PubMed]
[20] Zhan, X., Li, L., Wu, M. and Lang, J.H. (2019) The Prognosis of Stage IA Synchronous Endometrial Endometrioid and Ovarian Carcinomas. Archives of Gynecology and Obstetrics, 300, 1045-1052. [Google Scholar] [CrossRef] [PubMed]
[21] Young, R.H., Clement, P.B. and Scully, R.E. (2000) Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament: Atlas of Tumor Pathology. Archives of Pathology & Laboratory Medicine, 124, 477.

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