外周血炎性指标在食管癌术后吻合口瘘中的应用

The Application of Peripheral Blood Inflammatory Indexes in Postoperative Anastomotic Leakage in Esophageal Cancer

摘要: 食管癌术后吻合口瘘是食管切除手术后较为常见的严重并发症，不仅会导致患者住院时间延长，对医疗资源造成负担，还可能增加病死率，影响患者的总体生存质量。研究表明，食管癌手术后吻合口瘘的发生与血液中炎症指标的水平紧密相关。包括C-反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞计数(NEUT)、降钙素原(PCT)等，其中高水平的CRP、WBC和NEU与AL的发生率呈正相关，提示这些指标有望成为AL的预测因子。但传统炎性标志物在预测AL方面具有一定的局限性。因此，寻找更准确的预测指标是至关重要的，以便能够更好地评估食管癌术后AL的风险。本文综述了常见血液炎症指标在食管癌术后吻合口瘘(AL)中的应用，旨在为临床上早期预测AL的发生提供参考依据。

Abstract: Postoperative anastomotic leakage (AL) is one of the serious complications after resection of esophageal cancer, and its high incidence and long hospitalization time put pressure on medical resources, as well as increase mortality and shorten patients’ survival. Numerous studies have shown that there is a significant correlation between peripheral blood inflammatory indexes and AL after esophageal cancer surgery. These include C-reactive protein (CRP), white blood cell count (WBC), and neutrophil count (NEUT), etc. High levels of CRP, WBC, and NEU are positively correlated with the incidence of AL, suggesting that these markers are expected to be predictors of AL. However, traditional inflammatory markers have certain limitations in predicting AL. Therefore, it is crucial to find more accurate predictors to enable a better assessment of the risk of AL after esophageal cancer surgery. In this paper, we review the application of several common inflammatory markers in peripheral blood in postoperative AL of esophageal cancer, aiming to provide a more comprehensive reference index for the early diagnosis of postoperative AL of esophageal cancer.