美国成年人血汞和肝功能的关联：2015~2016年NHANES横断面研究

Association of Blood Mercury and Liver Function in US Adults: A 2015~2016 NHANES Cross-Sectional Study

摘要: 目的：研究2015年~2016年美国成年人血液中总汞含量与肝功能之间的关系。方法：NHANES公用数据库下载人口学资料、饮食资料、调查问卷和实验室资料，从中选取美国1638名20岁及以上的成年人作为研究对象，采用卡方检验和t检验进行统计分析，对人口统计学和生活方式因素进行多变量线性回归分析，以分析血汞浓度升高时肝功能指标的变化。结果：血液总汞为1.3771 ± 2.05657 μg/L，性别影响血汞和肝功能指标(p < 0.01)。BMI < 24的人群血汞浓度最高。血汞与肝功能指标中的ALT、ALT/AST有着显著正相关(p < 0.001)，与ALP存在显著负相关(p < 0.001)。女性和超重肥胖人群的血汞与多种肝功能指标存在显著相关性。糖尿病对于血汞和肝功能影响程度小。结论：血清汞浓度与肝功能指标存在相关性，但这一结果因性别、肥胖而异。

Abstract: Objective: To investigate the relationship between total mercury content in blood and liver function in American adults from 2015 to 2016. Method: Demographic, diet, questionnaire and laboratory data from the NHANES public database were selected from 1638 adults aged 20 years and older in the United States as research objects. Chi-square test and t-test were used for statistical analysis, and multivariate linear regression analysis was performed for demographic and lifestyle factors to analyze the changes of liver function indexes when blood mercury concentration increased. Results: Blood mercury was 1.3771 ± 2.05657 μg/L, and gender affected blood mercury and liver function indexes (p < 0.01). People with a BMI < 24 have the highest blood mercury concentration. Serum mercury was positively correlated with ALT, ALT/AST in liver function (p < 0.001), and negatively correlated with ALP (p < 0.001). There was significant correlation between blood mercury and various liver function indexes in women and overweight and obese people. Diabetes has little effect on blood mercury and liver function. Conclusion: There is a correlation between serum mercury concentration and liver function index, but this result varies according to gender and obesity.