单核细胞与高密度脂蛋白胆固醇比值在心血管疾病中的研究进展
Research Progress of Monocyte to High Density Lipoprotein Cholesterol Ratio in Cardiovascular Diseases
摘要: 随着社会经济的蓬勃发展和人们生活水平的逐步提高,心血管疾病(Cardiovascular diseases, CVD)对居民生命健康安全的影响愈发显著。在CVD的疾病过程中,炎症和脂质蓄积扮演了重要角色。近年来,一种新型的潜在炎症标志物——单核细胞与高密度脂蛋白胆固醇比值(Monocyte to high density lipoprotein cholesterol ratio, MHR)逐渐受到关注。作为一种综合型指标,它能够动态反映机体炎症和抗炎能力的整体趋势。研究表明,MHR的增高与不良心血管事件的发生密切相关。本文就MHR与CVD相关研究进行综述,旨在为CVD的早期识别及预后判断提供新依据。
Abstract: With the vigorous development of social economy and the gradual improvement of people’s living standards, the impact of cardiovascular diseases (CVD) on residents’ lives and health is becoming increasingly significant. Inflammation and lipid accumulation play an important role in the occurrence and development of CVD. In recent years, a new potential inflammatory marker—the monocyte to high density lipoprotein cholesterol ratio (MHR), has gradually attracted attention. As a comprehensive indicator, it can dynamically reflect the overall trend of inflammation and anti-inflammatory ability. Studies have shown that an increased MHR is closely associated with the occurrence of adverse cardiovascular events. This review of research on MHR and CVD aims to provide a new basis for the early identification and prognosis of CVD.
文章引用:何健, 易岂建. 单核细胞与高密度脂蛋白胆固醇比值在心血管疾病中的研究进展[J]. 临床医学进展, 2024, 14(4): 69-76. https://doi.org/10.12677/acm.2024.144989

参考文献

[1] 马丽媛, 王增武, 等. 《中国心血管健康与疾病报告2022》要点解读[J]. 中国全科医学, 2023, 26(32): 3975-3994.
[2] Ghattas, A., Griffiths, H.R., Devitt, A., Lip, G.Y. and Shantsila, E. (2013) Monocytes in Coronary Artery Disease and Atherosclerosis: Where Are We Now? Journal of the American College of Cardiology, 62, 1541-1551. [Google Scholar] [CrossRef] [PubMed]
[3] Movva, R. and Rader, D.J. (2008) Laboratory Assessment of HDL Heterogeneity and Function. Clinical Chemistry, 54, 788-800. [Google Scholar] [CrossRef] [PubMed]
[4] Soria-Florido, M.T., Schröder, H., Grau, M., Fitó, M. and Lassale, C (2020) High Density Lipoprotein Functionality and Cardiovascular Events and Mortality: A Systematic Review and Meta-Analysis. Atherosclerosis, 302, 36-42. [Google Scholar] [CrossRef] [PubMed]
[5] Kanbay, M., Solak, Y., Unal, H.U., Kurt, Y.G., Gok, M., Cetinkaya, H., et al. (2014) Monocyte Count/HDL Cholesterol Ratio and Cardiovascular Events in Patients with Chronic Kidney Disease. International Urology and Nephrology, 46, 1619-1625. [Google Scholar] [CrossRef] [PubMed]
[6] Cetin, M.S., Ozcan Cetin, E.H., Kalender, E., Aydin, S., Topaloglu, S., Kisacik, H.L., et al. (2016) Monocyte to HDL Cholesterol Ratio Predicts Coronary Artery Disease Severity and Future Major Cardiovascular Adverse Events in Acute Coronary Syndrome. Heart, Lung and Circulation, 25, 1077-1086. [Google Scholar] [CrossRef] [PubMed]
[7] Zhang, M., Wu, S., Xu, S. and Chen, S (2021) Impact of Monocyte to High-Density Lipoprotein Ratio on the Identification of Prevalent Coronary Heart Disease: Insights from a General Population. Postgraduate Medicine, 133, 822-829. [Google Scholar] [CrossRef] [PubMed]
[8] Sianos, G., Morel, M.A., Kappetein, A.P., Morice, M.C., Colombo, A., Dawkins, K., et al. (2005) The Syntax Score: An Angiographic Tool Grading the Complexity of Coronary Artery Disease. EuroIntervention, 1, 219-227.
[9] Serruys, P.W., Morice, M.C., Kappetein, A.P., Colombo, A., Holmes, D.R., Mack, M.J., et al. (2009) Percutaneous Coronary Intervention Versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease. The New England Journal of Medicine, 360, 961-972. [Google Scholar] [CrossRef
[10] Akboga, M.K., Balci, K.G., Maden, O., Ertem, A.G., Kirbas, O., Yayla, C., et al. (2016) Usefulness of Monocyte to HDL-Cholesterol Ratio to Predict High Syntax Score in Patients with Stable Coronary Artery Disease. Biomarkers in Medicinevol, 10, 375-383. [Google Scholar] [CrossRef] [PubMed]
[11] Wu, T.T., Zheng, Y.Y., Chen, Y., Yu, Z.X., Ma, Y.T. and Xie, X. (2019) Monocyte to High-Density Lipoprotein Cholesterol Ratio as Long-Term Prognostic Marker in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Lipids in Health and Disease, 18, Article No. 180. [Google Scholar] [CrossRef] [PubMed]
[12] Zhang, D.P., Baituola, G., Wu, T.T., Chen, Y., Hou, X.G., Yang, Y., et al. (2020) An Elevated Monocyte-to-High-Density Lipoprotein-Cholesterol Ratio Is Associated with Mortality in Patients with Coronary Artery Disease Who Have Undergone PCI. Bioscience Reports, 40, BSR20201108. [Google Scholar] [CrossRef
[13] McCrindle, B.W., Rowley, A.H., Newburger, J.W., Burns, J.C., Bolger, A.F., Gewitz, M., et al. (2017) Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals from the American Heart Association. Circulation, 135, e927-e999. [Google Scholar] [CrossRef
[14] Yang, C., Yang, Y., Cao, S., Ma, Z., Du, H., Li, J., et al. (2023) Kawasaki Disease Coronary Artery Lesions Prediction with Monocyte-to-High-Density Lipoprotein Ratio. Pediatric Research, 94, 246-251. [Google Scholar] [CrossRef] [PubMed]
[15] Wu, R., Jiang, W., Sun, Y., Wu, L., Di, Y., Wang, J., et al. (2023) Indicators of Oxidative Stress in the Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. JCR: Journal of Clinical Rheumatology, 29, 126-131. [Google Scholar] [CrossRef
[16] Evangelista, A., Isselbacher, E.M., Bossone, E., Gleason, T.G., Eusanio, M.D., Sechtem, U., et al. (2018) Insights from the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research. Circulation, 137, 1846-1860. [Google Scholar] [CrossRef
[17] Du, X., Zhang, S., Xu, J., Xiang, Q., Tian, F., Li, X., et al. (2020) Diagnostic Value of Monocyte to High-Density Lipoprotein Ratio in Acute Aortic Dissection in a Chinesehan Population. Expert Review of Molecular Diagnostics, 20, 1243-1252. [Google Scholar] [CrossRef] [PubMed]
[18] Xie, E., Yang, F., Luo, S., Liu, Y., Xue, L., Huang, W., et al. (2021) Association between Preoperative Monocyte to High-Density Lipoprotein Ratio on In-Hospital and Long-Term Mortality in Patients Undergoing Endovascular Repair for Acute Type B Aortic Dissection. Frontiers in Cardiovascular Medicine, 8, Article 775471. [Google Scholar] [CrossRef] [PubMed]
[19] Can, Y., Kocayiğit, I., Aksoy, M., Kılıç, H. and Akdemir, R. (2023) Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Subclavian Artery Stenosis. European Review for Medical and Pharmacological Sciences, 27, 1881-1888.
[20] Wang, Y., Li, D., Zhu, X., Li, J., Yue, C., Wu, L., et al. (2022) The Monocyte to High-Density Lipoprotein Cholesterol Ratio Is a Risk Factor for Frequent Premature Ventricular Complexes: A Retrospective Cohort Study. Lipids in Health and Disease, 21, Article No. 129. [Google Scholar] [CrossRef] [PubMed]
[21] Hu, Y.F., Chen, Y.J., Lin, Y.J. and Chen, S.A. (2015) Inflammation and the Pathogenesis of Atrial Fibrillation. Nature Reviews Cardiology, 12, 230-243. [Google Scholar] [CrossRef] [PubMed]
[22] Ulus, T., Isgandarov, K., Yilmaz, A.S., Vasi, I., Moghanchızadeh, S.H. and Mutlu, F. (2018) Predictors of New-Onset Atrial Fibrillation in Elderly Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention. Aging Clinical and Experimental Research, 30, 1475-1482. [Google Scholar] [CrossRef] [PubMed]
[23] Wang, L., Zhang, Y., Yu, B., Zhao, J., Zhang, W., Fan, H., et al. (2023) The Monocyte-to-High-Density Lipoprotein Ratio Is Associated with the Occurrence of Atrial Fibrillation among Nafld Patients: A Propensity-Matched Analysis. Frontiers in Endocrinology, 14, Article 1127425. [Google Scholar] [CrossRef] [PubMed]
[24] Canpolat, U., Aytemir, K., Yorgun, H., Şahiner, L., Kaya, E.B., Çay, S., et al. (2015) The Role of Preprocedural Monocyte-to-High-Density Lipoprotein Ratio in Prediction of Atrial Fibrillation Recurrence after Cryoballoon-Based Catheter Ablation. EP Europace, 17, 1807-1815. [Google Scholar] [CrossRef] [PubMed]
[25] Chen, S.A., Zhang, M.M., Zheng, M., Liu, F., Sun, L., Bao, Z.Y., et al. (2020) The Preablation Monocyte/ High Density Lipoprotein Ratio Predicts the Late Recurrence of Paroxysmal Atrial Fibrillation after Radiofrequency Ablation. BMC Cardiovascular Disorders, 20, Article No. 401. [Google Scholar] [CrossRef] [PubMed]
[26] Celik, T., Yuksel, U.C., Demirkol, S., Bugan, B., Iyisoy, A., Kabul, H.K., et al. (2011) Relationship between Increased Systemic Inflammation and Impaired Aortic Elasticity in Young Patients with Prehypertension. Blood Pressure Monitoring, 16, 55-61. [Google Scholar] [CrossRef
[27] Yayla, K.G., Canpolat, U., Yayla, Ç., Akboğa, M.K., Akyel, A., Akdi, A., et al. (2017) A Novel Marker of Impaired Aortic Elasticity in Never Treated Hypertensive Patients: Monocyte/High-Density Lipoprotein Cholesterol Ratio. Acta Cardiological Sinica, 33, 41-49.
[28] Zhou, Y., Dan, H., Bai, L., Jia, L., Lu, B., Gu, G., et al. (2022) Continuous Positive Linear Association between the Monocyte to High-Density Lipoprotein Cholesterol Ratio and Hypertension: A Cross-Sectional Study. International Journal of Hypertension, 2022, Article ID: 8501726. [Google Scholar] [CrossRef] [PubMed]
[29] Zhang, Y., Ding, Y. and Jiang, W (2023) Neutrophil and Monocyte Ratios to High-Density Lipoprotein Cholesterol as Biomarkers in Non-Dipping Hypertension. Clinical and Experimental Hypertension, 45, Article ID: 2210785. [Google Scholar] [CrossRef] [PubMed]
[30] Aydin, E., Ates, I., Fettah, A.M., Yilmaz, N. and Dede, F. (2017) The Ratio of Monocyte Frequency to HDL Cholesterol Level as a Predictor of Asymptomatic Organ Damage in Patients with Primary Hypertension. Hypertension Research, 40, 758-764. [Google Scholar] [CrossRef] [PubMed]
[31] Li, L., Zheng, Y., Ruan, H., Zhang, M., Wang, Z., Ma, M., et al. (2023) Assessing the Relationship between Monocyte to HDL Cholesterol Ratio and Mortality in Patients with Hypertrophic Cardiomyopathy. Hellenic Journal of Cardiology, 76, 58-67. [Google Scholar] [CrossRef] [PubMed]
[32] Ekizler, F.A., Cay, S., Açar, B., Tak, B.T., Kafes, H., Ozeke, O., et al. (2019) Monocyte to High-Density Lipoprotein Cholesterol Ratio Predicts Adverse Cardiac Events in Patients with Hypertrophic Cardiomyopathy. Biomarkers in Medicinevol, 13, 1175-1186. [Google Scholar] [CrossRef] [PubMed]
[33] Ekizler, F.A. and Cay, S. (2019) A Novel Marker of Persistent Left Ventricular Systolic Dysfunction in Patients with Peripartum Cardiomyopathy: Monocyte Count-to-HDL Cholesterol Ratio. BMC Cardiovascular Disorders, 19, Article No. 114. [Google Scholar] [CrossRef] [PubMed]
[34] Avci, A., Biricik, S., Avci, B.S., Yesiloglu, O., Sumbul, H.E., Icme, F., et al. (2021) The New Prognostic Factor for Pulmonary Embolism: The Ratio of Monocyte Count to HDL Cholesterol. The American Journal of Emergency Medicine, 46, 212-216. [Google Scholar] [CrossRef] [PubMed]
[35] Selvaggio, S., Brugaletta, G., Abate, A., Musso, C., Romano, M., Di Raimondo, D., et al. (2023) Platelet-to-Lymphocyte Ratio, Neutrophil-to-Lymphocyte Ratio and Monocyte-to-HDL Cholesterol Ratio as Helpful Biomarkers for Patients Hospitalized for Deep Vein Thrombosis. International Journal of Molecular Medicine, 51, Article 52. [Google Scholar] [CrossRef] [PubMed]
[36] Arısoy, A., Altunkaş, F., Karaman, K., Karayakalı, M., Çelik, A., Ceyhan, K., et al. (2017) Association of the Monocyte to HDL Cholesterol Ratio with Thrombus Burden in Patients with ST-Segment Elevation Myocardial Infarction. Clinical and Applied Thrombosis/Hemostasis, 23, 992-997. [Google Scholar] [CrossRef] [PubMed]