维生素D与肝纤维化相关性的研究进展
Research Progress on the Correlation between Vitamin D and Liver Fibrosis
摘要: 肝纤维化(HF)是一种慢性肝病，也是终末期肝细胞癌的主要原因，其特征是细胞外基质(ECM)沉积，是ECM合成和降解不平衡的结果。随着过去几十年的深入研究，揭示了维生素D在肝脏疾病中的可能作用，对维生素D、维生素D受体(VDR)和维生素D的结合蛋白(VDBP)参与肝脏炎症和纤维化形成的深入理解为诊断肝纤维化、判断肝病预后和治疗肝病新策略奠定了基础。本文对维生素D与肝纤维化的相关性研究进展进行综述。
Abstract: Hepatic fibrosis (HF), a chronic liver disease and a major cause of end-stage hepatocellular carcinoma, is characterized by extracellular matrix (ECM) deposition, the result of an imbalance in ECM synthesis and degradation. As the past few decades have revealed the possible role of vitamin D in liver disease, a better understanding of the involvement of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (VDBP) in liver inflammation and fibrosis formation has laid the foundation for diagnosing liver fibrosis, determining the prognosis of liver disease, and new strategies for the treatment of liver disease. This article reviews the research progress on the correlation between vitamin D and liver fibrosis.
文章引用：古再奴尔·艾买尔江, 古丽巴哈尔·司马义. 维生素D与肝纤维化相关性的研究进展[J]. 临床医学进展, 2024, 14(4): 121-125. https://doi.org/10.12677/acm.2024.144997

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