IL-6和D-二聚体与冠心病的研究进展
Research Progress of IL-6 and D-Dimer and Coronary Heart Disease
DOI: 10.12677/acm.2024.1441013, PDF,   
作者: 苏比依努尔·斯拉积丁, 谢 翔*：新疆医科大学第一附属医院高血压科，新疆 乌鲁木齐
关键词: 白细胞介素-6；D-二聚体；冠心病；Interleukin-6； D-Dimer； Coronary Heart Disease
摘要: 冠心病是心血管疾病中最常见的疾病，冠状动脉粥样硬化的开始和发展是一个复杂的过程，由血栓形成和炎症共同驱动。白细胞介素作为重要的炎症因子，在动脉粥样硬化的发生和发展过程中起到了重要作用，其中白细胞介素-6 (Interleukin 6, IL-6)是家族中的重要一员。D-二聚体(D-dimer, DD)是由纤维蛋白溶解系统对血栓的有序分解产物，是临床凝血和纤溶激活的重要检测指标，在血栓性疾病中具有重要的临床价值。本文对就与冠心病关系较为密切的IL-6和D-二聚体的研究进展进行综述。
Abstract: Coronary heart disease is the most common disease of cardiovascular disease, and the onset and progression of coronary atherosclerosis is a complex process, driven by both thrombosis and inflammation. As an important inflammatory factor, Interleukin plays an important role in the occurrence and development of atherosclerosis, and interleukin-6 (IL-6) is an important member of the family. D-dimer (DD) is the ordered breakdown product of thrombus by fibrinolytic system, which is an important indicator of clinical coagulation and fibrinolytic activation, and has important clinical value in thrombotic diseases. This article reviews the research progress of IL-6 and D-dimer which are closely related to coronary heart disease.
文章引用：苏比依努尔·斯拉积丁, 谢翔. IL-6和D-二聚体与冠心病的研究进展[J]. 临床医学进展, 2024, 14(4): 244-250. https://doi.org/10.12677/acm.2024.1441013

参考文献

[1] Lewington, S., Clarke, R., Qizilbash, N., et al., Prospective Studies Collaboration (2002) Age-Specific Relevance of Usual Blood Pressure to Vascular Mortality: A Meta-Analysis of Individual Data for One Million Adults in 61 Prospective Studies. The Lancet, 360, 1903-1913. [Google Scholar] [CrossRef] 
[2] Leon, B.M. and Maddox, T.M. (2015) Diabetes and Cardiovascular Disease: Epidemiology, Biological Mechanisms, Treatment Recommendations and Future Research. World Journal of Diabetes, 6, 1246-1258. [Google Scholar] [CrossRef] [PubMed]
[3] Jung, E., Kong, S.Y., Ro, Y.S., et al. (2022) Serum Cholesterol Levels and Risk of Cardiovascular Death: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies. International Journal of Environmental Research and Public Health, 19, Article 8272. [Google Scholar] [CrossRef] [PubMed]
[4] Tavakoly, A.A., Sany, S.B., Ghayour-Mobarhan, M., et al. (2018) Serum C-Reactive Protein in the Prediction of Cardiovascular Diseases: Overview of the Latest Clinical Studies and Public Health Practice. Journal of Cellular Physiology, 233, 8508-8525. [Google Scholar] [CrossRef] [PubMed]
[5] 刘俊田. 动脉粥样硬化发病的炎症机制的研究进展[J]. 西安交通大学学报(医学版), 2015(2): 141-152.
[6] Libby, P. (2021) The Changing Landscape of Atherosclerosis. Nature, 592, 524-533. [Google Scholar] [CrossRef] [PubMed]
[7] Ray, A., Tatter, S.B., Santhanam, U., et al. (1989) Regulation of Expression of Interleukin-6. Molecular and Clinical Studies. Annals of the New York Academy of Sciences, 557, 353-362. [Google Scholar] [CrossRef] 
[8] Lesina, M., Wörmann, S.M., Neuhöfer, P., et al. (2014) Interleukin-6 in Inflammatory and Malignant Diseases of the Pancreas. Seminars in Immunology, 26, 80-87. [Google Scholar] [CrossRef] [PubMed]
[9] Tripodi, A. (2011) D-Dimer Testing in Laboratory Practice. Clinical Chemistry, 57, 1256-1262. [Google Scholar] [CrossRef] [PubMed]
[10] Johnson, E.D., Schell, J.C. and Rodgers, G.M. (2019) The D-Dimer Assay. American Journal of Hematology, 94, 833-839. [Google Scholar] [CrossRef] [PubMed]
[11] Weitz, J.I., Fredenburgh, J.C. and Eikelboom, J.W. (2017) A Test in Context: D-Dimer. Journal of the American College of Cardiology, 70, 2411-2420. [Google Scholar] [CrossRef] [PubMed]
[12] Simes, J., Robledo, K.P., White, H.D., et al. (2018) D-Dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events, and Cancer in Patients with Stable Coronary Heart Disease. Circulation, 138, 712-723. [Google Scholar] [CrossRef] 
[13] Kyrle, P.A. and Eichinger, S. (2018) D-Dimer for Long-Term Risk Prediction in Patients after Acute Coronary Syndrome. Circulation, 138, 724-726. [Google Scholar] [CrossRef] 
[14] Seino, Y., Ikeda, U., Ikeda, M., et al. (1994) Interleukin 6 Gene Transcripts Are Expressed in Human Atherosclerotic Lesions. Cytokine, 6, 87-91. [Google Scholar] [CrossRef] [PubMed]
[15] Recinos, A., LeJeune, W.S., Sun, H., et al. (2007) Angiotensin II Induces IL-6 Expression and the Jak-STAT3 Pathway in Aortic Adventitia of LDL Receptor-Deficient Mice. Atherosclerosis, 194, 125-133. [Google Scholar] [CrossRef] [PubMed]
[16] Ishibashi, T., Kimura, H., Shikama, Y., et al. (1989) Interleukin-6 Is a Potent Thrombopoietic Factor in Vivo in Mice. Blood, 74, 1241-1244. [Google Scholar] [CrossRef] 
[17] Neumann, F.J., Ott, I., Marx, N., et al. (1997) Effect of Human Recombinant Interleukin-6 and Interleukin-8 on Monocyte Procoagulant Activity. Arteriosclerosis, Thrombosis, and Vascular Biology, 17, 3399-3405. [Google Scholar] [CrossRef] 
[18] Schuett, H., Luchtefeld, M., Grothusen, C., et al. (2009) How Much Is Too Much? Interleukin-6 and Its Signalling in Atherosclerosis. Thrombosis and Haemostasis, 102, 215-222. [Google Scholar] [CrossRef] 
[19] Hägg, D., Sjöberg, S., Hultén, L.M., et al. (2007) Augmented Levels of CD44 in Macrophages from Atherosclerotic Subjects: A Possible IL-6-CD44 Feedback Loop? Atherosclerosis, 190, 291-297. [Google Scholar] [CrossRef] [PubMed]
[20] Krettek, A., Sukhova, G.K., Schönbeck, U., et al. (2004) Enhanced Expression of CD44 Variants in Human Atheroma and Abdominal Aortic Aneurysm: Possible Role for a Feedback Loop in Endothelial Cells. The American Journal of Pathology, 165, 1571-1581. [Google Scholar] [CrossRef] 
[21] Ikeda, U., Ito, T. and Shimada, K. (2001) Interleukin-6 and Acute Coronary Syndrome. Clinical Cardiology, 24, 701-704. [Google Scholar] [CrossRef] [PubMed]
[22] Yamauchi-Takihara, K., Ihara, Y., Ogata, A., et al. (1995) Hypoxic Stress Induces Cardiac Myocyte-Derived Interleukin-6. Circulation, 91, 1520-1524. [Google Scholar] [CrossRef] 
[23] Lee, K.W., Lip, G.Y., Tayebjee, M., et al. (2005) Circulating Endothelial Cells, Von Willebrand Factor, Interleukin-6, and Prognosis in Patients with Acute Coronary Syndromes. Blood, 105, 526-532. [Google Scholar] [CrossRef] [PubMed]
[24] Reichert, S., Schlitt, A., Benten, A.C., et al. (2016) Data on IL-6 c.-174 G>C Genotype and Allele Frequencies in Patients with Coronary Heart Disease in Dependence of Cardiovascular Outcome. Data in Brief, 8, 1295-1299. [Google Scholar] [CrossRef] [PubMed]
[25] Rodondi, N., Marques-Vidal, P., Butler, J., et al. (2010) Markers of Atherosclerosis and Inflammation for Prediction of Coronary Heart Disease in Older Adults. American Journal of Epidemiology, 171, 540-549. [Google Scholar] [CrossRef] [PubMed]
[26] 刘晓柳, 李光千. 白介素-6及其受体与心血管系统的研究进展[J]. 细胞与分子免疫学杂志, 2009, 25(2): 189-191.
[27] Biasucci, L.M., Vitelli, A., Liuzzo, G., et al. (1996) Elevated Levels of Interleukin-6 in Unstable Angina. Circulation, 94, 874-877. [Google Scholar] [CrossRef] 
[28] Batra, G., Lakic, T.G., Lindbäck, J., et al. (2021) Interleukin 6 and Cardiovascular Outcomes in Patients with Chronic Kidney Disease and Chronic Coronary Syndrome. JAMA Cardiology, 6, 1440-1445. [Google Scholar] [CrossRef] [PubMed]
[29] Sanders, J., Hawe, E., Brull, D.J., et al. (2009) Higher IL-6 Levels but not IL6-174G>C or-572G>C Genotype Are Associated with Post-Operative Complication Following Coronary Artery Bypass Graft (CABG) Surgery. Atherosclerosis, 204, 196-201. [Google Scholar] [CrossRef] [PubMed]
[30] Ikeda, U. (2003) Inflammation and Coronary Artery Disease. Current Vascular Pharmacology, 1, 65-70. [Google Scholar] [CrossRef] [PubMed]
[31] 林小梅, 祖姆热提∙阿布都克依木, 马春晖, 等. 血清白介素6、空腹血糖水平与冠心病及不良心血管事件关系的研究[J]. 中国全科医学, 2024, 27(3): 286-292.
[32] Adam, S.S., Key, N.S. and Greenberg, C.S. (2009) D-Dimer Antigen: Current Concepts and Future Prospects. Blood, 113, 2878-2887. [Google Scholar] [CrossRef] [PubMed]
[33] Hoeprich Jr., P.D. and Doolittle, R.F. (1983) Dimeric Half-Molecules of Human Fibrinogen Are Joined through Disulfide Bonds in an Antiparallel Orientation. Biochemistry, 22, 2049-2055. [Google Scholar] [CrossRef] [PubMed]
[34] Mosesson, M.W., Siebenlist, K.R., Hainfeld, J.F., et al. (1995) The Covalent Structure of Factor XIIIa Crosslinked Fibrinogen Fibril. Journal of Structural Biology, 115, 88-101. [Google Scholar] [CrossRef] [PubMed]
[35] Longstaff, C. and Kolev, K. (2015) Basic Mechanisms and Regulation of Fibrinolysis. Journal of Thrombosis and Haemostasis, 13, S98-S105. [Google Scholar] [CrossRef] [PubMed]
[36] 庄德荣, 何胜虎, 蔡定华, 等. hs-CRP、D-二聚体和Lp-PLA2与冠心病患者冠状动脉粥样硬化易损斑块的相关性[J]. 现代生物医学进展, 2017, 17(26): 5131-5133.
[37] Kothari, H., Nguyen, A.T., Yang, X., et al. (2018) Association of D-Dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease. Journal of Cardiovascular Translational Research, 11, 221-229. [Google Scholar] [CrossRef] [PubMed]
[38] Soomro, A.Y., Guerchicoff, A., Nichols, D.J., et al. (2016) The Current Role and Future Prospects of D-Dimer Biomarker. European Heart Journal-Cardiovascular Pharmacotherapy, 2, 175-184. [Google Scholar] [CrossRef] [PubMed]
[39] 任爱平, 杨叶, 叶阳. 不稳定型心绞痛患者凝血纤溶指标的变化[J]. 西部医学, 2007, 19(5): 791-792.
[40] Tokita, Y., Kusama, Y., Kodani, E., et al. (2009) Utility of Rapid D-Dimer Measurement for Screening of Acute Cardiovascular Disease in the Emergency Setting. Journal of Cardiology, 53, 334-340. [Google Scholar] [CrossRef] [PubMed]
[41] Patil, S.M., Bankar, M.P., Padalkar, R.K., et al. (2014) Study of Plasma Fibrin D-Dimer as Marker of Fibrinolysis and High Sensitive C-Reactive Protein (hs-CRP) as Potential Inflammatory Marker in Acute Stage of Coronary Heart Diseases. Journal of Indian College of Cardiology, 4, 8-13. [Google Scholar] [CrossRef] 
[42] Gong, X., Lei, X., Huang, Z., et al. (2021) D-Dimer Level Predicts Angiographic No-Reflow Phenomenon after Percutaneous Coronary Intervention within 2-7 Days of Symptom Onset in Patients with ST-Segment Elevation Myocardial Infarction. Journal of Cardiovascular Translational Research, 14, 728-734. [Google Scholar] [CrossRef] [PubMed]
[43] Mjelva, Ø.R., Pönitz, V., Brügger-Andersen, T., et al. (2016) Long-Term Prognostic Utility of Pentraxin 3 and D-Dimer as Compared to High-Sensitivity C-Reactive Protein and B-Type Natriuretic Peptide in Suspected Acute Coronary Syndrome. European Journal of Preventive Cardiology, 23, 1130-1140. [Google Scholar] [CrossRef] [PubMed]
[44] 何东明. 血清高敏C反应蛋白和白细胞介素-6水平对冠心病病情评估的价值[J]. 中华实用诊断与治疗杂志, 2012, 26(2): 135-136, 140.
[45] Frossard, J.L., Steer, M.L. and Pastor, C.M. (2008) Acute Pancreatitis. The Lancet, 371, 143-152. [Google Scholar] [CrossRef] 
[46] Ghanavatian, S., Stein, R.A., Atar, D., et al. (2011) The Course of D-Dimer, High-Sensitivity C-Reactive Protein and Pro-B-Type Natriuretic Peptide in Patients with Non-ST-Elevation Myocardial Infarction. Clinical Laboratory, 57, 771-776.
[47] 王蓉, 胡东南. D-二聚体和纤维蛋白原的检测在不同类型冠心病诊断中的意义[J]. 中国医药导报, 2006, 3(35): 158 162.

为你推荐