肝脏脂肪分数(UDFF)对多囊卵巢综合征患者肝脏脂肪含量的定量评估

Quantitative Evaluation of Ultrasound Derived Fat Fraction (UDFF) on Liver Fat Content in Patients with Polycystic Ovary Syndrome

摘要: 目的：探讨肝脏脂肪分数(UDFF)对多囊卵巢综合征(PCOS)患者肝脏脂肪含量定量分析的价值。方法：选择2022年10月~2023年10月于青岛大学附属医院就诊的61例PCOS患者作为研究组，选择年龄相匹配的121例健康女性作为对照组，全部研究对象进行妇科多普勒超声检查及UDFF采集，测量研究对象的身高、体重、腹围、血压、空腹血糖、空腹胰岛素、胰岛素抵抗(HOMA-IR)，雄激素(T)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)，比较两组资料，分析UDFF与各指标的相关性。结果：两组间BMI、腹围、HOMA-IR、T、TG、HDL比较差异有统计学意义(均P < 0.05)，UDFF与体重指数(BMI)、腹围、HOMA-IR、T、TG、HDL均相关(P均 < 0.01)，多元逐步回归分析显示，HOMA-IR、T、TG是UDFF的影响因素。结论：UDFF技术可以早期发现并定量分析多囊卵巢综合征患者的肝脏脂肪浸润，UDFF是一个新型、无创的定量评估肝脏脂肪含量的影像学技术。

Abstract: Objective: To explore the value of ultrasound derived fat fraction (UDFF) in quantitative analysis of liver fat content in patients with polycystic ovary syndrome (PCOS). Method: 61 PCOS patients who visited the Affiliated Hospital of Qingdao University from October 2022 to October 2023 were selected as the study group, and 121 healthy women who matched their age were selected as the control group. All study subjects underwent gynecological Doppler ultrasound examination and UDFF collection, and their height, weight, abdominal circumference, blood pressure, fasting blood glucose, fasting insulin, insulin resistance (HOMA-IR), androgen (T), and triglycerides (TG) were measured High density lipoprotein (HDL) and low-density lipoprotein (LDL) were compared to analyze the correlation between UDFF and various indicators. Results: The results showed that there was a statistically significant difference in BMI, abdominal circumference, HOMA-IR, T, TG, and HDL between the two groups (all P < 0.05). UDFF was correlated with body mass index (BMI), abdominal circumference, HOMA-IR, T, TG, and HDL (all P < 0.01). Multiple stepwise regression analysis showed that HOMA-IR, T, and TG were the influencing factors of UDFF. Conclusion: UDFF technology can detect and quantitatively analyze liver fat infiltration in patients with polycystic ovary syndrome in the early stage. UDFF is a novel, non-invasive imaging technique for quantitatively assessing liver fat content.