皮肤晚期糖基化终末产物在预测2型糖尿病患者血管并发症中作用的研究进展
Research Progress of Skin Advanced Glycation End Products in Predicting Vascular Complications in Patients with Type 2 Diabetes Mellitus
DOI: 10.12677/acm.2024.1441166, PDF,   
作者: 娜扎开提·尼加提：新疆医科大学第一附属医院，新疆 乌鲁木齐；蒋 升*：新疆医科大学第一附属医院内分泌科，新疆 乌鲁木齐
关键词: 晚期糖基化终末产物；2型糖尿病；血管并发症；Late Glycation End Products； Type 2 Diabetes； Vascular Complications
摘要: 皮肤晚期糖基化终末产物(AGEs)是由还原糖和蛋白质等氨基通过不可逆的化学反应产生的最终产物。它能够通过各种方式对人体的糖代谢产生影响。研究发现，在患有糖尿病和相关血管并发症的人群中，AGEs的水平通常会有明显的上升。这类异常增高的AGEs不仅导致了血管的快速老化，还触发了一连串的炎症反应，从而加速了相关并发症的发展。因此，有必要了解其作用机制并加以防治。本文深入探讨了AGEs的生成、积累以及它们对糖代谢和血管的伤害机制，旨在为未来预防和治疗糖尿病及其导致的动脉粥样硬化提供新的研究方向。
Abstract: Advanced glycation end products (AGEs) of the skin are the final products produced by irreversible chemical reactions of amino groups such as reducing sugars and proteins. It can affect the human body’s sugar metabolism in various ways. The study found that the level of AGEs usually increased significantly in people with diabetes and related vascular complications. These abnormally elevated AGEs not only lead to rapid aging of blood vessels, but also trigger a series of inflammatory reactions, thereby accelerating the development of related complications. Therefore, it is necessary to understand its mechanism of action and take preventive measures. In this paper, the generation and accumulation of AGEs and their damage mechanism to glucose metabolism and blood vessels were discussed in depth, aiming to provide a new research direction for the prevention and treatment of diabetes and atherosclerosis caused by it in the future.
文章引用：娜扎开提·尼加提, 蒋升. 皮肤晚期糖基化终末产物在预测2型糖尿病患者血管并发症中作用的研究进展[J]. 临床医学进展, 2024, 14(4): 1345-1350. https://doi.org/10.12677/acm.2024.1441166

参考文献

[1] 陈榕, 成艳美, 郑小飞, 等. 糖尿病与衰老的相关性及机制研究进展[J]. 转化医学杂志, 2023, 12(4): 204-209, 214.
[2] 汤运梁, 徐积兄. 糖基化终末产物与糖尿病慢性并发症研究进展[J]. 中国老年学杂志, 2017, 37(4): 1012-1015.
[3] Twarda-Clapa, A., Olczak, A., Białkowska, A.M. and Koziołkiewicz, M. (2022) Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs. Cells, 11, Article 1312. [Google Scholar] [CrossRef] [PubMed]
[4] Goldberg, T., Cai, W., Peppa, M., Dardaine, V., Baliga, B.S., Uribarri, J. and Vlassara, H. (2004) Advanced Glycoxidation End Products in Commonly Consumed Foods. Journal of the American Dietetic Association, 104, 1287-1291. [Google Scholar] [CrossRef] [PubMed]
[5] Shen, C.Y., Lu, C.H., Wu, C.H., Li, K.J., Kuo, Y.M., Hsieh, S.C. and Yu, C.L. (2020) The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases. Molecules, 25, Article 5591. [Google Scholar] [CrossRef] [PubMed]
[6] Ott, C., Jacobs, K., Haucke, E., Santos, A.N., Grune, T. and Simm, A. (2014) Role of Advanced Glycation End Products in Cellular Signaling. Redox Biology, 2, 411-429. [Google Scholar] [CrossRef] [PubMed]
[7] Tamura, Y., Adachi, H., Osuga, J.I., Ohashi, K., Yahagi, N., Sekiya, M., Okazaki, H., Tomita, S., Iizuka, Y., Shimano, H., Nagai, R., Kimura, S., Tsujimoto, M. and Ishibashi, S. (2003) FEEL-1 and FEEL-2 Are Endocytic Receptors for Advanced Glycation End Products.Journal of Biological Chemistry, 278, 12613-12617. [Google Scholar] [CrossRef] 
[8] Kobori, T., Ganesh, D., Kumano-Kuramochi, M., Torigoe, K. and Machida, S. (2020) Assay for Advanced Glycation End Products Generating Intracellular Oxidative Stress through Binding to Its Receptor. Analytical Biochemistry, 611, Article ID: 114018. [Google Scholar] [CrossRef] [PubMed]
[9] Horiuchi, S., Sakamoto, Y. and Sakai, M. (2003) Scavenger Receptors for Oxidized and Glycated Proteins. Amino Acids, 25, 283-292. [Google Scholar] [CrossRef] [PubMed]
[10] Bucciarelli, L.G., Wendt, T., Rong, L., Lalla, E., Hofmann, M.A., Goova, M.T., Taguchi, A., Yan, S.F., Yan, S.D., Stern, D.M. and Schmidt, A.M. (2002) RAGE Is a Multiligand Receptor of the Immunoglobulin Superfamily: Implications for Homeostasis and Chronic Disease. Cellular and Molecular Life Sciences, 59, 1117-1128. [Google Scholar] [CrossRef] [PubMed]
[11] Park, K.H. and Park, W.J. (2015) Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease and Therapeutic Approaches. Journal of Korean Medical Science, 30, 1213-1225. [Google Scholar] [CrossRef] [PubMed]
[12] Pertynska-Marczewska, M. and Merhi, Z. (2015) Relationship of Advanced Glycation End Products with Cardiovascular Disease in Menopausal Women. Reproductive Sciences, 22, 774-782. [Google Scholar] [CrossRef] [PubMed]
[13] 朱明敏. 2型糖尿病患者并发大血管病变的危险因素分析[J]. 现代医学与健康研究电子杂志, 2024, 8(1): 122-124.
[14] Won, K.B., Chang, H.J., Park, S.H., Hong, S.Y., Jang, Y. and Chung, N. (2012) High Serum Advanced Glycation End-Products Predict Coronary Artery Disease Irrespective of Arterial Stiffness in Diabetic Patients. Korean Circulation Journal, 42, 335-340. [Google Scholar] [CrossRef] [PubMed]
[15] Kitano, D., Takayama, T., Nagashima, K., Akabane, M., Okubo, K., Hiro, T. and Hirayama, A. (2016) A Comparative Study of Time-Specific Oxidative Stress after Acute Myocardial Infarction in Patients with and without Diabetes Mellitus. BMC Cardiovascular Disorders, 16, Article No. 102. [Google Scholar] [CrossRef] [PubMed]
[16] Griendling, K.K. and FitzGerald, G.A. (2003) Oxidative Stress and Cardiovascular Injury: Part II: Animal and Human Studies. Circulation, 108, 2034-2040. [Google Scholar] [CrossRef] 
[17] Kiuchi, K., Nejima, J., Takano, T., Ohta, M. and Hashimoto, H. (2001) Increased Serum Concentrations of Advanced Glycation End Products: A Marker of Coronary Artery Disease Activity in Type 2 Diabetic Patients. Heart, 85, 87-91. [Google Scholar] [CrossRef] [PubMed]
[18] Wautier, M.P., Chappey, O., Corda, S., Stern, D.M., Schmidt, A.M. and Wautier, J.L. (2001) Activation of NADPH Oxidase by AGE Links Oxidant Stress to Altered Gene Expression via RAGE. American Journal of Physiology: Endocrinology and Metabolism, 280, E685-E694. [Google Scholar] [CrossRef] 
[19] Koska, J., Saremi, A., Howell, S., Bahn, G., De Courten, B., Ginsberg, H., Beisswenger, P.J., Reaven, P.D. and VADT Investigators (2018) Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients with Type 2 Diabetes. Diabetes Care, 41, 570-576. [Google Scholar] [CrossRef] [PubMed]
[20] Belmokhtar, K., Ortillon, J., Jaisson, S., Massy, Z.A., Boulagnon Rombi, C., Doué, M., Maurice, P., Fritz, G., Gillery, P., Schmidt, A.M., Rieu, P. and Touré, F. (2019) Receptor for Advanced Glycation End Products: A Key Molecule in the Genesis of Chronic Kidney Disease Vascular Calcification and a Potential Modulator of Sodium Phosphate Co-Transporter PIT-1 Expression. Nephrology, Dialysis, Transplantation, 34, 2018-2030. [Google Scholar] [CrossRef] [PubMed]
[21] Zhuang, A. and Forbes, J.M. (2016) Diabetic Kidney Disease: A Role for Advanced Glycation End-Product Receptor 1 (AGE-R1)? Glycoconjugate Journal, 33, 645-652. [Google Scholar] [CrossRef] [PubMed]
[22] Teissier, T., Quersin, V., Gnemmi, V., Daroux, M., Howsam, M., Delguste, F., Lemoine, C., Fradin, C., Schmidt, A.M., Cauffiez, C., Brousseau, T., Glowacki, F., Tessier, F.J., Boulanger, E. and Frimat, M. (2019) Knockout of Receptor for Advanced Glycation End-Products Attenuates Age-Related Renal Lesions. Aging Cell, 18, e12850. [Google Scholar] [CrossRef] [PubMed]
[23] Nishad, R., Tahaseen, V., Kavvuri, R., Motrapu, M., Singh, A.K., Peddi, K. and Pasupulati, A.K. (2021) Advanced-Glycation End-Products Induce Podocyte Injury and Contribute to Proteinuria. Frontiers in Medicine, 8, Article 685447. [Google Scholar] [CrossRef] [PubMed]

为你推荐