脑肿瘤患儿的神经认知功能预后
Prognosis of Neurocognitive Function in Children with Brain Tumors
DOI: 10.12677/acm.2024.1441204, PDF,   
作者: 汤卓杭, 梁 平*：重庆医科大学附属儿童医院神经外科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，重庆
关键词: 脑肿瘤；神经认知功能；儿童；Brain Tumor； Neurocognitive Function； Children
摘要: 脑肿瘤(Brain Tumor, BT)在儿童中是仅次于白血病的第二大常见恶性肿瘤，医学诊断和治疗技术的进步提高了生存率，但如何有效改善认知功能预后仍然是一个挑战。近年来对脑肿瘤患儿认知功能预后的研究不断深入，本文对以上研究进行系统回顾，探索BT对儿童认知功能的影响、相关危险因素以及干预措施，以期改善BT患儿的认知功能和生活质量。
Abstract: Brain tumors are the second most common malignant tumors in children after leukemia. Advances in medical diagnosis and treatment have improved survival rates, but effectively improving cognitive function prognosis remains a challenge. In recent years, research into the prognosis of cognitive function in children with brain tumors has deepened. This article systematically reviews the above studies, exploring the impact of brain tumors on cognitive function in children, related risk factors, and intervention measures, with the aim of improving the cognitive function and quality of life of children with brain tumors.
文章引用：汤卓杭, 梁平. 脑肿瘤患儿的神经认知功能预后[J]. 临床医学进展, 2024, 14(4): 1647-1653. https://doi.org/10.12677/acm.2024.1441204

参考文献

[1] 马杰. 我国儿童中枢神经系统肿瘤诊治现状[J]. 中华神经外科疾病研究杂志, 2018, 17(3): 193-197.
[2] Steliarova-Foucher, E., Colombet, M., Ries, L.A.G., et al. (2017) International Incidence of Childhood Cancer, 2001-10: A Population-Based Registry Study. Lancet Oncology, 18, 719-731. [Google Scholar] [CrossRef] 
[3] Quon, J.L., Bala, W., Chen, L.C., et al. (2020) Deep Learning for Pediatric Posterior Fossa Tumor Detection and Classification: A Multi-Institutional Study. AJNR American Journal of Neuroradiology, 41, 1718-1725. [Google Scholar] [CrossRef] 
[4] 余建忠, 施伟, 赵瑞, 等. 儿童髓母细胞瘤的临床特点及预后相关因素分析[J]. 临床小儿外科杂志, 2020, 19(3): 236-240, 247.
[5] Millard, N.E. and De Braganca, K.C. (2016) Medulloblastoma. Journal of Child Neurology, 31, 1341-1353. [Google Scholar] [CrossRef] [PubMed]
[6] 黄怀忠. 髓母细胞瘤的诊治研究新进展[J]. 国际神经病学神经外科学杂志, 2010, 37(3): 241-246.
[7] Weil, A.G., Wang, A.C., Westwick, H.J., et al. (2017) Survival in Pediatric Medulloblastoma: A Population-Based Observational Study to Improve Prognostication. Journal of Neuro-Oncology, 132, 99-107. [Google Scholar] [CrossRef] [PubMed]
[8] Macartney, G., Harrison, M.B., VanDenKerkhof, E., Stacey, D. and McCarthy, P. (2014) Quality of Life and Symptoms in Pediatric Brain Tumor Survivors: A Systematic Review. Journal of Pediatric Oncology Nursing, 31, 65-77. [Google Scholar] [CrossRef] [PubMed]
[9] Mulhern, R.K., Merchant, T.E., Gajjar, A., et al. (2004) Late Neurocognitive Sequelae in Survivors of Brain Tumours in Childhood. Lancet Oncology, 5, 399-408. [Google Scholar] [CrossRef] 
[10] Janzen, L.A. (2016) Long-Term Neurocognitive and Functional Effects of Treatment for Childhood Acute Lymphoblastic Leukaemia. Lancet Psychiatry, 3, 912-913. [Google Scholar] [CrossRef] 
[11] Armstrong, G.T., Jain, N., Liu, W., et al. (2010) Region-Specific Radiotherapy and Neuropsychological Outcomes in Adult Survivors of Childhood CNS Malignancies. Neuro-Oncology, 12, 1173-1186. [Google Scholar] [CrossRef] [PubMed]
[12] Bloom, H.J., Wallace, E.N. and Henk, J.M. (1969) The Treatment and Prognosis of Medulloblastoma in Children: A Study of 82 Verified Cases. The American Journal of Roentgenology Radium Therapy and Nuclear Medicine, 105, 43-62. [Google Scholar] [CrossRef] [PubMed]
[13] Palmer, S.L. (2008) Neurodevelopmental Impact on Children Treated for Medulloblastoma: A Review and Proposed Conceptual Model. Developmental Disabilities Research Reviews, 14, 203-210. [Google Scholar] [CrossRef] [PubMed]
[14] Saury, J.M. and Emanuelson, I. (2011) Cognitive Consequences of the Treatment of Medulloblastoma among Children. Pediatric Neurology, 44, 21-30. [Google Scholar] [CrossRef] [PubMed]
[15] Hanzlik, E., Woodrome, S.E., Abdel-Baki, M., et al. (2015) A Systematic Review of Neuropsychological Outcomes Following Posterior Fossa Tumor Surgery in Children. Child’s Nervous System, 31, 1869-1875. [Google Scholar] [CrossRef] [PubMed]
[16] Merchant, T.E., Schreiber, J.E., Wu, S., et al. (2014) Critical Combinations of Radiation Dose and Volume Predict Intelligence Quotient and Academic Achievement Scores after Craniospinal Irradiation in Children with Medulloblastoma. International Journal of Radiation Oncology, Biology, Physics, 90, 554-561. [Google Scholar] [CrossRef] [PubMed]
[17] Palmer, S.L., Goloubeva, O., Reddick, W.E., et al. (2001) Patterns of Intellectual Development among Survivors of Pediatric Medulloblastoma: A Longitudinal Analysis. Journal of Clinical Oncology, 19, 2302-2308. [Google Scholar] [CrossRef] 
[18] Kieffer-Renaux, V., Bulteau, C., Grill, J., et al. (2000) Patterns of Neuropsychological Deficits in Children with Medulloblastoma According to Craniospatial Irradiation Doses. Developmental Medicine & Child Neurology, 42, 741-745. [Google Scholar] [CrossRef] 
[19] Chevignard, M., Câmara-Costa, H., Doz, F., et al. (2017) Core Deficits and Quality of Survival after Childhood Medulloblastoma: A Review. Neuro-Oncology Practice, 4, 82-97. [Google Scholar] [CrossRef] [PubMed]
[20] Feldman, H.M. (2019) The Importance of Language-Learning Environments to Child Language Outcomes. Pediatrics, 144, e20192157. [Google Scholar] [CrossRef] [PubMed]
[21] Stavinoha, P.L., Askins, M.A., Powell, S.K., Pillay Smiley, N. and Robert, R.S. (2018) Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors. Bioengineering, 5, Article 73. [Google Scholar] [CrossRef] [PubMed]
[22] Mabbott, D.J., Spiegler, B.J., Greenberg, M.L., et al. (2005) Serial Evaluation of Academic and Behavioral Outcome after Treatment with Cranial Radiation in Childhood. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 23, 2256-2263. [Google Scholar] [CrossRef] 
[23] Corti, C., Poggi, G., Massimino, M., et al. (2018) Visual Perception and Spatial Transformation of the Body in Children and Adolescents with Brain Tumor. Neuropsychologia, 120, 124-136. [Google Scholar] [CrossRef] [PubMed]
[24] Conklin, H.M., Li, C., Xiong, X., et al. (2008) Predicting Change in Academic Abilities after Conformal Radiation Therapy for Localized Ependymoma. Journal of Clinical Oncology, 26, 3965-3970. [Google Scholar] [CrossRef] 
[25] Mulhern, R.K., Reddick, W.E., Palmer, S.L., et al. (1999) Neurocognitive Deficits in Medulloblastoma Survivors and White Matter Loss. Annals of Neurology, 46, 834-841. [Google Scholar] [CrossRef] 
[26] Hardy, K.K., Willard, V.W., Allen, T.M., et al. (2013) Working Memory Training in Survivors of Pediatric Cancer: A Randomized Pilot Study. Psycho-Oncology, 22, 1856-1865. [Google Scholar] [CrossRef] [PubMed]
[27] Reeves, C.B., Palmer, S.L., Reddick, W.E., et al. (2006) Attention and Memory Functioning among Pediatric Patients with Medulloblastoma. Journal of Pediatric Psychology, 31, 272-280. [Google Scholar] [CrossRef] [PubMed]
[28] Brière, M.E., Scott, J.G., McNall-Knapp, R.Y., et al. (2008) Cognitive Outcome in Pediatric Brain Tumor Survivors: Delayed Attention Deficit at Long-Term Follow-Up. Pediatric Blood & Cancer, 50, 337-340. [Google Scholar] [CrossRef] [PubMed]
[29] King, T.Z., Fennell, E.B., Williams, L., et al. (2004) Verbal Memory Abilities of Children with Brain Tumors. Child Neuropsychology, 10, 76-88. [Google Scholar] [CrossRef] [PubMed]
[30] Edelstein, K., Spiegler, B.J., Fung, S., et al. (2011) Early Aging in Adult Survivors of Childhood Medulloblastoma: Long-Term Neurocognitive, Functional, and Physical Outcomes. Neuro-Oncology, 13, 536-545. [Google Scholar] [CrossRef] [PubMed]
[31] Maddrey, A.M., Bergeron, J.A., Lombardo, E.R., et al. (2005) Neuropsychological Performance and Quality of Life of 10-Year Survivors of Childhood Medulloblastoma. Journal of Neuro-Oncology, 72, 245-253. [Google Scholar] [CrossRef] [PubMed]
[32] Conklin, H.M., Reddick, W.E., Ashford, J., Ogg, S., Howard, S.C., Morris, E.B., Brown, R., Bonner, M., Christensen, R., Wu, S., Xiong, X. and Khan, R.B. (2010) Long-Term Efficacy of Methylphenidate in Enhancing Attention Regulation, Social Skills, and Academic Abilities of Childhood Cancer Survivors. Journal of Clinical Oncology, 28, 4465-4472. [Google Scholar] [CrossRef] 
[33] Wolfe, K.R., Madan-Swain, A. and Kana, R.K. (2012) Executive Dysfunction in Pediatric Posterior Fossa Tumor Survivors: A Systematic Literature Review of Neurocognitive Deficits and Interventions. Developmental Neuropsychology, 37, 153-175. [Google Scholar] [CrossRef] [PubMed]
[34] Armstrong, C.L., Hunter, J.V., Ledakis, G.E., et al. (2002) Late Cognitive and Radiographic Changes Related to Radiotherapy: Initial Prospective Findings. Neurology, 59, 40-48. [Google Scholar] [CrossRef] 
[35] Koustenis, E., Hernáiz Driever, P., et al. (2016) Executive Function Deficits in Pediatric Cerebellar Tumor Survivors. European Journal of Paediatric Neurology, 20, 25-37. [Google Scholar] [CrossRef] [PubMed]
[36] George, A.P., Kuehn, S.M., Vassilyadi, M., et al. (2003) Cognitive Sequelae in Children with Posterior Fossa Tumors. Pediatric Neurology, 28, 42-47. [Google Scholar] [CrossRef] 
[37] Anderson, V., Spencer-Smith, M., Leventer, R., et al. (2009) Childhood Brain Insult: Can Age at Insult Help Us Predict Outcome? Brain, 132, 45-56. [Google Scholar] [CrossRef] [PubMed]
[38] Mulhern, R.K., Palmer, S.L., Reddick, W.E., et al. (2001) Risks of Young Age for Selected Neurocognitive Deficits in Medulloblastoma Are Associated with White Matter Loss. Journal of Clinical Oncology, 19, 472-479. [Google Scholar] [CrossRef] 
[39] Desmond, J.E. and Fiez, J.A. (1998) Neuroimaging Studies of the Cerebellum: Language, Learning and Memory. Trends in Cognitive Sciences, 2, 355-362. [Google Scholar] [CrossRef] 
[40] Hardy, K.K., Bonner, M.J., Willard, V.W., et al. (2008) Hydrocephalus as a Possible Additional Contributor to Cognitive Outcome in Survivors of Pediatric Medulloblastoma. Psycho-Oncology, 17, 1157-1161. [Google Scholar] [CrossRef] [PubMed]
[41] Kao, G.D., Goldwein, J.W., Schultz, D.J., et al. (1994) The Impact of Perioperative Factors on Subsequent Intelligence Quotient Deficits in Children Treated for Medulloblastoma/Posterior Fossa Primitive Neuroectodermal Tumors. Cancer, 74, 965-971. [Google Scholar] [CrossRef] 
[42] 戎宏涛, 岳树源, 惠旭辉. 小脑性缄默症[J]. 中华神经外科杂志, 2015, 31(1): 101-103.
[43] Siffert, J., Poussaint, T.Y., Goumnerova, L.C., et al. (2000) Neurological Dysfunction Associated with Postoperative Cerebellar Mutism. Journal of Neuro-Oncology, 48, 75-81. [Google Scholar] [CrossRef] 
[44] Miller, N.G., Reddick, W.E., Kocak, M., et al. (2010) Cerebellocerebral Diaschisis Is the Likely Mechanism of Postsurgical Posterior Fossa Syndrome in Pediatric Patients with Midline Cerebellar Tumors. AJNR American Journal of Neuroradiology, 31, 288-294. [Google Scholar] [CrossRef] 
[45] Gudrunardottir, T., Sehested, A., Juhler, M., et al. (2011) Cerebellar Mutism: Definitions, Classification and Grading of Symptoms. Child’s Nervous System, 27, 1361-1363. [Google Scholar] [CrossRef] [PubMed]
[46] Lawrence, Y.R., Li, X.A., el Naqa, I., et al. (2010) Radiation Dose-Volume Effects in the Brain. International Journal of Radiation Oncology, Biology, Physics, 76, S20-S27. [Google Scholar] [CrossRef] [PubMed]
[47] Grill, J., Renaux, V.K., Bulteau, C., et al. (1999) Long-Term Intellectual Outcome in Children with Posterior Fossa Tumors According to Radiation Doses and Volumes. International Journal of Radiation Oncology, Biology, Physics, 45, 137-145. [Google Scholar] [CrossRef] 
[48] Moxon-Emre, I., Bouffet, E., Taylor, M.D., et al. (2014) Impact of Craniospinal Dose, Boost Volume, and Neurologic Complications on Intellectual Outcome in Patients with Medulloblastoma. Journal of Clinical Oncology, 32, 1760-1768. [Google Scholar] [CrossRef] 
[49] Palmer, S.L., Gajjar, A., Reddick, W.E., et al. (2003) Predicting Intellectual Outcome among Children Treated with 35-40 Gy Craniospinal Irradiation for Medulloblastoma. Neuropsychology, 17, 548-555. [Google Scholar] [CrossRef] [PubMed]
[50] Nagel, B.J., Delis, D.C., Palmer, S.L., et al. (2006) Early Patterns of Verbal Memory Impairment in Children Treated for Medulloblastoma. Neuropsychology, 20, 105-112. [Google Scholar] [CrossRef] [PubMed]
[51] Conklin, H.M., Ogg, R.J., Ashford, J.M., et al. (2015) Computerized Cognitive Training for Amelioration of Cognitive Late Effects among Childhood Cancer Survivors: A Randomized Controlled Trial. Journal of Clinical Oncology, 33, 3894-3902. [Google Scholar] [CrossRef] 

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