水凝胶治疗骨关节炎的作用机制

The Mechanism of Hydrogels in the Treatment of Osteoarthritis

摘要: 骨关节炎是一种以关节软骨退化为主要特征，并常常伴有炎症的关节疾病。骨关节炎的发病率随着全球老龄化人口增多持续升高，造成患者生活质量下降。目前的治疗方法有药物、理疗或手术等，但在效果上仍有其不足。近些年来，一种创新生物材料——水凝胶，因其具有多种可调节特性在骨关节炎治疗领域备受关注。它不仅能够作为物理支撑，还能提供润滑效果、抗炎作用以及作为生物活性分子的递送载体，这些特性将为骨关节炎的治疗寻找到新的策略。本文将对水凝胶治疗骨关节炎的多种作用机制进行深入探讨。

Abstract: Osteoarthritis (OA) is a common joint disease, the core problem of which lies in the gradual degeneration of articular cartilage and the accompanying inflammatory response. With the trend of global population aging, the incidence of OA continues to rise, seriously threatening the quality of daily life of patients. Although current treatment strategies include pharmacotherapy, physical therapy, and surgical intervention, these methods still have shortcomings in effectiveness and adaptability. In recent years, hydrogels have shown their versatility as an innovative biomaterial in the field of OA treatment: not only can they serve as physical support, but they can also provide lubrication, anti-inflammatory effects and serve as delivery vehicles for bioactive molecules. These properties open up new avenues for the treatment of OA. This article will conduct an in-depth discussion of the multiple mechanisms of action of hydrogels in the treatment of OA.