椎管内麻醉中常用辅助镇静药物的研究进展
Research Progress on Adjuvant Sedative Drugs Commonly Used in Neuraxial Anesthesia
DOI: 10.12677/acm.2024.1441228, PDF,   
作者: 柴欢欢:延安大学医学院,陕西 延安;李玲霞*:延安大学附属医院麻醉科,陕西 延安
关键词: 椎管内麻醉镇静丙泊酚咪达唑仑右美托咪定瑞马唑仑Neuraxial Anesthesia Sedation Propofol Midazolam Dexmedetomidine Remimazolam
摘要: 近年来,随着麻醉技术的不断提升和无痛舒适化医疗理念的推广,麻醉工作不仅仅只局限在术中镇痛,我们不仅要考虑患者围术期的生理变化,同时要考虑到患者的心理变化。椎管内麻醉在临床麻醉中是不可缺少的麻醉方法,麻醉后患者意识处于清醒状态,手术医师的操作,手术间里的机械声音等会使患者感觉恐惧和不适,为了减少患者焦虑,紧张的状态,麻醉医师常辅助一些镇静药物来使患者达到睡眠状态,从而使患者在手术过程中不愉快的情绪减少。随着医疗技术不断提高,不同种类麻醉药物也在不断更新,选择一种起效快、代谢快、副作用小、安全性高的麻醉药品对麻醉医师来说非常重要。本文就目前几种常用的静脉镇静药物的特点及应用展开综述。
Abstract: In recent years, with the continuous improvement of anesthesia technology and the promotion of the concept of painless and comfortable medical treatment, anesthesia work is not only limited to intraoperative analgesia, we should not only consider the physiological changes of patients during the perioperative period, but also take into account the psychological changes of patients. Neuraxial anesthesia is an indispensable anesthesia method in clinical anesthesia, after anesthesia, the patient’s consciousness is in a state of awakening, the operation of the surgeon, the mechanical sound in the operating room, etc., will make the patient feel frightened and uncomfortable, in order to reduce the patient’s anxiety and nervousness, the anesthesiologist often assists some sedative drugs to make the patient reach a sleep state, so that the patient’s unpleasant emotions during the operation are reduced. With the continuous improvement of medical technology, different types of anesthetic drugs are also constantly updated, and it is very important for anesthesiologists to choose a narcotic drug with fast onset, fast metabolism, few side effects and high safety. This article reviews the characteristics and applications of several commonly used intravenous sedative drugs.
文章引用:柴欢欢, 李玲霞. 椎管内麻醉中常用辅助镇静药物的研究进展[J]. 临床医学进展, 2024, 14(4): 1801-1812. https://doi.org/10.12677/acm.2024.1441228

参考文献

[1] Lim, .TW., Choi, Y.H., Kim, J.Y., et al. (2020) Efficacy of the Bispectral Index and Observer’s Assessment of Alertness/Sedation Scale in Monitoring Sedation during Spinal Anesthesia: A Randomized Clinical Trial. Journal of International Medical Research, 48. [Google Scholar] [CrossRef] [PubMed]
[2] 温亚彬, 颜如玉, 马晓静, 赵通, 王维刚, 赵建辉, 姜博, 宋铁鹰. 右美托咪定辅助镇静对老年患者椎管内麻醉术后睡眠功能的影响[J]. 河北医药, 2016, 38(8): 1228-1230.
[3] 林兰英, 林财珠. 丙泊酚对老年术后早期认知功能与炎性细胞因子的影响[J]. 临床麻醉学杂志, 2011, 27(3): 254-256.
[4] Chawla, N., Boateng, A. and Deshpande, R. (2017) Procedural Sedation in the ICU and Emergency Department. Current Opinion in Anaesthesiology, 30, 507-512. [Google Scholar] [CrossRef
[5] Antkowiak, B. and Rammes, G. (2019) GABA(A) Receptor-Targeted Drug Development—New Perspectives in Perioperative Anesthesia. Expert Opinion on Drug Discovery, 14, 683-699. [Google Scholar] [CrossRef] [PubMed]
[6] Wang, W., Wu, L., Zhang, C., et al. (2017) Is Propofol Injection Pain Really Important to Patients? BMC Anesthesiology, 17, Article No. 24. [Google Scholar] [CrossRef] [PubMed]
[7] 高宏燕, 谭晶. 丙泊酚注射痛的发生机制及其预防药物的研究进展[J]. 中国医药, 2022, 17(2): 312-315..
[8] 谢本发, 牛居辉, 何睿, 许伟, 朱辉, 张庆兵. 纳布啡在无痛胃肠镜检查中减轻丙泊酚静脉注射痛的效果[J]. 中国内镜杂志, 2023, 29(7): 15-19.
[9] 林丹丹, 吴声升. 小剂量利多卡因对女性无痛胃镜检查中丙泊酚注射痛的影响[J]. 妇儿健康导刊, 2023, 2(15): 131-133.
[10] 谭潮, 吴浩, 于乐洋, 严诗婷, 王莹, 田顺平, 周炜, 眭伟, 张转. 预先静脉注射利多卡因预防丙泊酚中/长链脂肪乳注射痛的半数有效量[J]. 实用临床医药杂志, 2022, 26(2): 132-136.
[11] Eleveld, D.J., Colin, P., Absalom, A.R., et al. (2018) Pharmacokinetic-Pharmacodynamic Model for Propofol for Broad Application in Anaesthesia and Sedation. British Journal of Anaesthesia, 120, 942-959. [Google Scholar] [CrossRef] [PubMed]
[12] 陈丽嫦. 小剂量丙泊酚治疗40例老年人术后谵妄的临床观察[J]. 中外医学研究, 2021, 19(17): 157-159.
[13] Royse, C.F., Liew, D.F., Wright, C.E., Royse, A.G. and Angus, J.A. (2008) Persistent Depression of Contractility and Vasodilation with Propofol But Not with Sevoflurane or Desflurane in Rabbits. Anesthesiology, 108, 87-93. [Google Scholar] [CrossRef] [PubMed]
[14] Boules, R., Szkiladz, A. and Nogid, A. (2012) Fospropofol Disodium (Lusedra) Injection for Anesthesia-Care Sedation: A Clinical Review. PT, 37, 395-422.
[15] Moore, G.D., Walker, A.M. and MacLaren, R. (2009) Fospropofol: A New Sedative-Hypnotic Agent for Monitored Anesthesia Care. Annals of Pharmacotherapy, 43, 1802-1808. [Google Scholar] [CrossRef
[16] Byrne, M.F. and Baillie, J. (2002) Propofol for Conscious Sedation? Gastroenterology, 123, 373-375. [Google Scholar] [CrossRef] [PubMed]
[17] 杨俊华, 郑光军. 丙泊酚持续静脉输注辅助椎管内麻醉镇静的临床观察[J]. 临床医学工程, 2011, 18(2): 247-248.
[18] 莫晓飞, 梁慧明, 肖艳红, 等. 丙泊酚镇静辅助硬膜外麻醉对患者心理应激的影响[J]. 南方医科大学学报, 2018, 38(12): 1498-1502.
[19] 张云飞. 丙泊酚镇静辅助硬膜外麻醉对患者心理应激的影响[J]. 心理月刊, 2021, 16(6): 66-67, 215. [Google Scholar] [CrossRef
[20] Ivano, FH., Romeiro, PC., Matias, JE., et al. (2010) Estudo Comparativo de Eficácia e Segurança entre Propofol e Midazolam Durante Sedação Para Colonoscopia [Comparative Study of Efficacy and Safety Between Propofol and Midazolam for Sedation during Colonoscopy]. Revista do Colégio Brasileiro de Cirurgiões, 37, 10-16. [Google Scholar] [CrossRef
[21] Ito, H., Watanabe, Y., Isshiki, A. and Uchino, H. (1999) Neuroprotective Properties of Propofol and Midazolam, But Not Pentobarbital, on Neuronal Damage Induced by Forebrain Ischemia, Based on the GABAA Receptors. Acta Anaesthesiologica Scandinavica, 43, 153-162. [Google Scholar] [CrossRef] [PubMed]
[22] Muller, S., Borowics, S.M., Fortis, E.A., et al. (2008) Clinical Efficacy of Dexmedetomidine Alone Is Less than Propofol for Conscious Sedation during ERCP. Gastrointestinal Endoscopy, 67, 651-659. [Google Scholar] [CrossRef] [PubMed]
[23] Ustün, Y., Gündüz, M., Erdo Gan, O., et al. (2006) Dexmedetomidine versus Midazolam in Outpatient Third Molar Surgery. Journal of Oral and Maxillofacial Surgery, 64, 1353-1358. [Google Scholar] [CrossRef] [PubMed]
[24] Zhou, W.J., Liu, M. and Fan, X.P. (2021) Differences in Efficacy and Safety of Midazolam vs. Dexmedetomidine in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trial. Experimental and Therapeutic Medicine, 21, Article Number 156. [Google Scholar] [CrossRef] [PubMed]
[25] Akhtar, S. (2018) Pharmacological Considerations in the Elderly. Current Opinion in Anaesthesiology, 31, 11-18. [Google Scholar] [CrossRef
[26] Bauer, T.M., Ritz, R., Haberthür, C., Ha, H.R., Hunkeler, W., Sleight, A.J., Scollo-Lavizzari, G. and Haefeli, W.E. (1995) Prolonged Sedation Due to Accumulation of Conjugated Metabolites of Midazolam. Lancet, 346, 145-147. [Google Scholar] [CrossRef
[27] Cakir, M., Polat, A., Tekin, S., et al. (2015) The Effect of Dexmedetomidine Against Oxidative and Tubular Damage Induced by Renal Ischemia Reperfusion in Rats. Renal Failure, 37, 704-708. [Google Scholar] [CrossRef
[28] Barends, C.R., Absalom, A., Van Minnen, B., Vissink, A. and Visser, A. (2017) Dexmedetomidine versus Midazolam in Procedural Sedation. A Systematic Review of Efficacy and Safety. PLOS ONE, 12, e0169525. [Google Scholar] [CrossRef] [PubMed]
[29] Weerink, M.A.S., Struys, M.M.R.F., Hannivoort, L.N., Barends, C.R.M., Absalom, A.R. and Colin, P. (2017) Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clinical Pharmacokinetics, 56, 893-913. [Google Scholar] [CrossRef] [PubMed]
[30] 梁永新, 古妙宁, 王世端, 芦相玉. 硬膜外麻醉下妇科手术患者右美托咪啶和咪达唑仑镇静效果的比较[J]. 中华麻醉学杂志, 2010, 30(7): 887-888.
[31] 杨明宝. 右美托咪定辅助镇静用于椎管内麻醉患者的效果分析[J]. 智慧健康, 2023, 9(11): 158-161 166. [Google Scholar] [CrossRef
[32] Cheung, C.W., Ying, C.L., Chiu, W.K., Wong, G.T., Ng, K.F. and Irwin, M.G. (2007) A Comparison of Dexmedetomidine and Midazolam for Sedation in Third Molar Surgery. Anaesthesia, 62, 1132-1138. [Google Scholar] [CrossRef] [PubMed]
[33] Dumas, J.A. (2017) Strategies for Preventing Cognitive Decline in Healthy Older Adults. The Canadian Journal of Psychiatry, 62, 754-760. [Google Scholar] [CrossRef] [PubMed]
[34] Chen, N., Chen, X., Xie, J., Wu, C. and Qian, J. (2019) Dexmedetomidine Protects Aged Rats from Postoperative Cognitive Dysfunction by Alleviating Hippocampal Inflammation. Molecular Medicine Reports, 20, 2119-2126. [Google Scholar] [CrossRef] [PubMed]
[35] 宋歌, 王兵, 李龙, 等. 右美托咪定对腰麻下老年髋关节置换术患者应激反应、肾脏功能及睡眠质量的影响[J]. 现代生物医学进展, 2023, 23(19): 3772-3776, 3753. [Google Scholar] [CrossRef
[36] Shin, H.J., et al. (2023) Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial. Anesthesiology, 138, 164-171. [Google Scholar] [CrossRef
[37] 张雅瑞, 侯庆明. 右美托咪定对神经元氧糖剥夺/复氧损伤的保护作用[J/OL]. 青岛大学学报(医学版): 1-5.
http://kns.cnki.net/kcms/detail/37.1517.r.20240228.1250.001.html, 2024-03-03.
[38] Delwadia, S., Naguib, A. and Tobias, JD. (2012) Dexmedetomidine Controls Supraventricular Tachycardia Following Cardiac Surgery in a Child. World Journal for Pediatric and Congenital Heart Surgery, 3, 406-409. [Google Scholar] [CrossRef] [PubMed]
[39] Chrysostomou, C., Beerman, L., Shiderly, D., Berry, D., Morell, V.O. and Munoz, R. (2008) Dexmedetomidine: A Novel Drug for the Treatment of Atrial and Junctional Tachyarrhythmias during the Perioperative Period for Congenital Cardiac Surgery: A Preliminary Study. Anesthesia & Analgesia, 107, 1514-1522. [Google Scholar] [CrossRef] [PubMed]
[40] 芦相玉, 王宏涛, 王世端, 李瑜. 比较右美托咪定、丙泊酚、咪达唑仑辅助硬膜外麻醉镇静的效果[J]. 中国新药与临床杂志, 2011, 30(11): 873-877.
[41] Jakob, S.M., Ruokonen, E., Grounds, R.M., et al. (2012) Dexmedetomidine vs Midazolam or Propofol for Sedation during Prolonged Mechanical Ventilation: Two Randomized Controlled Trials. JAMA, 307, 1151-1160. [Google Scholar] [CrossRef] [PubMed]
[42] Whizar, V., Garnica, C. and Gastelum, R. (2016) Remimazolam: A New Ultra Short Acting Benzodiazepine. Journal of Anesthesia & Critical Care, 4, Article 00166. [Google Scholar] [CrossRef
[43] Goudra, B.G. and Singh, P.M. (2014) Remimazolam: The Future of Its Sedative Potential. Saudi Journal of Anaesthesia, 8, 388-391. [Google Scholar] [CrossRef
[44] Kilpatrick, G.J., McIntyre, M.S., Cox, R.F., et al. (2007) CNS 7056: A Novel Ultra-Short-Acting Benzodiazepine. Anesthesiology, 107, 60-66. [Google Scholar] [CrossRef] [PubMed]
[45] Antonik, L.J., Goldwater, D.R., Kilpatrick, G.J., Tilbrook, G.S. and Borkett, K.M. (2012) A Placebo-and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part I. Safety, Efficacy, and Basic Pharmacokinetics. Anesthesia & Analgesia, 115, 274-283. [Google Scholar] [CrossRef
[46] Wiltshire, H.R., Kilpatrick, G.J., Tilbrook, G.S. and Borkett, K.M. (2012) A Placebo-and Midazolam-Controlled Phase I Single Ascending-Dose Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of Remimazolam (CNS 7056): Part II. Population Pharmacokinetic and Pharmacodynamic Modeling and Simulation. Anesthesia & Analgesia, 115, 284-296. [Google Scholar] [CrossRef
[47] Schüttler, J., Eisenried, A., Lerch, M., Fechner, J., Jeleazcov, C. and Ihmsen, H. (2020) Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics. Anesthesiology, 132, 636-651. [Google Scholar] [CrossRef
[48] Wesolowski, A.M., Zaccagnino, M.P., Malapero, R.J., Kaye, A.D. and Urman, R.D. (2016) Remimazolam: Pharmacologic Considerations and Clinical Role in Anesthesiology. Pharmacotherapy, 36, 1021-1027. [Google Scholar] [CrossRef] [PubMed]
[49] Upton, R.N., Somogyi, A.A., Martinez, A.M., Colvill, J. and Grant, C. (2010) Pharmacokinetics and Pharmacodynamics of the Short-Acting Sedative CNS 7056 in Sheep. British Journal of Anaesthesia, 105, 798-809. [Google Scholar] [CrossRef] [PubMed]
[50] Deng, Y., Qin, Z., Wu, Q., et al. (2022) Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium after Orthopedic Surgery: A Randomized Controlled Trial. Drug Design, Development and Therapy, 16, 2439-2451. [Google Scholar] [CrossRef
[51] Zhou, Y., Hu, P. and Jiang, J. (2017) Metabolite Characterization of a Novel Sedative Drug, Remimazolam in Human Plasma and Urine Using Ultra High-Performance Liquid Chromatography Coupled with Synapt High-Definition Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 137, 78-83. [Google Scholar] [CrossRef] [PubMed]
[52] Lee, A. and Shirley, M. (2021) Remimazolam: A Review in Procedural Sedation. Drugs, 81, 1193-1201. [Google Scholar] [CrossRef] [PubMed]
[53] Lohmer, L.L., Schippers, F., Petersen, K.U., Stoehr, T. and Schmith, V.D. (2020) Time-to-Event Modeling for Remimazolam for the Indication of Induction and Maintenance of General Anesthesia. The Journal of Clinical Pharmacology, 60, 505-514. [Google Scholar] [CrossRef] [PubMed]
[54] Sheng, X.Y., Liang, Y., Yang, X.Y., et al. (2020) Safety, Pharmacokinetic and Pharmacodynamic Properties of Single Ascending Dose and Continuous Infusion of Remimazolam Besylate in Healthy Chinese Volunteers. European Journal of Clinical Pharmacology, 76, 383-391. [Google Scholar] [CrossRef] [PubMed]
[55] Worthington, M.T., Antonik, L.J., Goldwater, D.R., et al. (2013) A Phase Ib, Dose-Finding Study of Multiple Doses of Remimazolam (CNS 7056) in Volunteers Undergoing Colonoscopy. Anesthesia & Analgesia, 117, 1093-1100. [Google Scholar] [CrossRef
[56] Vicari, J.J. (2016) Sedation in the Ambulatory Endoscopy Center: Optimizing Safety, Expectations and Throughput. Gastrointestinal Endoscopy Clinics of North America, 26, 539-552. [Google Scholar] [CrossRef] [PubMed]
[57] Moon, S.H., Kim, H.K., Myung, D.S., Yoon, S.M. and Moon, W. (2017) 진정내시경시환자의감감시및관련장비 [Patient Monitoring and Associated Devices during Endoscopic Sedation]. The Korean Journal of Gastroenterology, 69, 64-67. [Google Scholar] [CrossRef] [PubMed]
[58] Borkett, K.M., Riff, D.S., Schwartz, H.I., et al. (2015) A Phase IIa, Randomized, Double-Blind Study of Remimazolam (CNS 7056) versus Midazolam for Sedation in Upper Gastrointestinal Endoscopy. Anesthesia & Analgesia, 120, 771-780. [Google Scholar] [CrossRef
[59] Chen, S.H., Yuan, T.M., Zhang, J., et al. (2021) Remimazolam Tosilate in Upper Gastrointestinal Endoscopy: A Multicenter, Randomized, Non-Inferiority, Phase III Trial. Journal of Gastroenterology and Hepatology, 36, 474-481. [Google Scholar] [CrossRef] [PubMed]
[60] Tan, Y., Ouyang, W., Tang, Y., Fang, N., Fang, C. and Quan, C. (2022) Effect of Remimazolam Tosilate on Early Cognitive Function in Elderly Patients Undergoing Upper Gastrointestinal Endoscopy. Journal of Gastroenterology and Hepatology, 37, 576-583. [Google Scholar] [CrossRef] [PubMed]
[61] Cao, Y., Chi, P., Zhou, C., Lv, W., Quan, Z. and Xue, F.S. (2022) Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study. Medical Science Monitor, 28, e936580. [Google Scholar] [CrossRef
[62] Rex, D.K., Bhandari, R., Desta, T., et al. (2018) A Phase III Study Evaluating the Efficacy and Safety of Remimazolam (CNS 7056) Compared with Placebo and Midazolam in Patients Undergoing Colonoscopy. Gastrointestinal Endoscopy, 88, 427-437.E6. [Google Scholar] [CrossRef] [PubMed]
[63] Rex, D.K., Bhandari, R., Lorch, D.G., et al. (2021) Safety and Efficacy of Remimazolam in High Risk Colonoscopy: A Randomized Trial. Digestive and Liver Disease, 53, 94-101. [Google Scholar] [CrossRef] [PubMed]
[64] Rex, D.K., Bhandari, R., Lorch, D.G., Meyers, M., Schippers, F. and Bernstein, D. (2021) Safety and Efficacy of Remimazolam in High Risk Colonoscopy: A Randomized Trial. Digestive and Liver Disease, 53, 94-101. [Google Scholar] [CrossRef] [PubMed]
[65] Yao, Y., Guan, J., Liu, L., Fu, B., Chen, L. and Zheng, X. (2022) Discharge Readiness after Remimazolam versus Propofol for Colonoscopy: A Randomised, Double-Blind Trial. European Journal of Anaesthesiology, 39, 911-917. [Google Scholar] [CrossRef
[66] Pastis, N.J., Yarmus, L.B., Schippers, F., et al. (2019) Safety and Efficacy of Remimazolam Compared with Placebo and Midazolam for Moderate Sedation during Bronchoscopy. Chest, 155, 137-146. [Google Scholar] [CrossRef] [PubMed]
[67] Chen, X., Xin, D., Xu, G., Zhao, J. and Lv, Q. (2022) The Efficacy and Safety of Remimazolam Tosilate versus Dexmedetomidine in Outpatients Undergoing Flexible Bronchoscopy: A Prospective, Randomized, Blind, Non-Inferiority Trial. Frontiers in Pharmacology, 13, Article 902065. [Google Scholar] [CrossRef] [PubMed]
[68] Masui, K. (2020) Remimazolam Besilate, A Benzodiazepine, Has Been Approved for General Anesthesia! Journal of Anesthesia, 34, 479-482. [Google Scholar] [CrossRef] [PubMed]
[69] Doi, M., Morita, K., Takeda, J., Sakamoto, A., Yamakage, M. and Suzuki, T. (2020) Efficacy and Safety of Remimazolam versus Propofol for General Anesthesia: A Multicenter, Single-Blind, Randomized, Parallel-Group, Phase IIb/III Trial. Journal of Anesthesia, 34, 543-553. [Google Scholar] [CrossRef] [PubMed]
[70] Doi, M., Hirata, N., Suzuki, T., Morisaki, H., Morimatsu, H. and Sakamoto, A. (2020) Safety and Efficacy of Remimazolam in Induction and Maintenance of General Anesthesia in High-Risk Surgical Patients (ASA Class III): Results of A Multicenter, Randomized, Double-Blind, Parallel-Group Comparative Trial. Journal of Anesthesia, 34, 491-501. [Google Scholar] [CrossRef] [PubMed]
[71] Chae, D., Kim, H.C., Song, Y., Choi, Y.S. and Han, D.W. (2022) Pharmacodynamic Analysis of Intravenous Bolus Remimazolam for Loss of Consciousness in Patients Undergoing General Anaesthesia: A Randomised, Prospective, Double-Blind Study. British Journal of Anaesthesia, 129, 49-57. [Google Scholar] [CrossRef] [PubMed]
[72] Luo, L., Jiang, J., Zhang, M., Guo, Z., Zhang, X., Wang, F. and Yang, F. (2023) Comparative Study about Different Doses of Remimazolam in Short Laparoscopic Surgery: A Randomized Controlled Double-Blind Trial. Therapeutics and Clinical Risk Management, 19, 829-837. [Google Scholar] [CrossRef
[73] Furuta, M., Ito, H. and Yamazaki, M. (2021) Anaesthetic Management Using Remimazolam in a Patient with Severe Aortic Stenosis: A Case Report. BMC Anesthesiology, 21, Article No. 202. [Google Scholar] [CrossRef] [PubMed]
[74] Shi, F., Chen, Y., Li, H., Zhang, Y. and Zhao, T. (2022) Efficacy and Safety of Remimazolam Tosilate versus Propofol for General Anesthesia in Cirrhotic Patients Undergoing Endoscopic Variceal Ligation. International Journal of General Medicine, 15, 583-591. [Google Scholar] [CrossRef
[75] Liu, S., Su, L., Zhang, B., et al. (2021) The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients under Mechanical Ventilation in ICU: Protocol for a Randomized, Open-Label, Controlled Trial. Frontiers in Medicine, 8, Article 735473. [Google Scholar] [CrossRef] [PubMed]
[76] 刘超, 周岐龙, 陈建国, 等. 瑞马唑仑用于重症患者镇静的研究进展[J]. 现代医药卫生, 2021, 37(20): 3492-3496.
[77] Zhou, J., Leonowens, C., Ivaturi, V.D., et al. (2020) Population Pharmacokinetic/Pharmacodynamic Modeling for Remimazolam in the Induction and Maintenance of General Anesthesia in Healthy Subjects and in Surgical Subjects. Journal of Clinical Anesthesia, 66, Article ID: 109899. [Google Scholar] [CrossRef] [PubMed]
[78] Io, T., Saunders, R., Pesic, M., Petersen, K.U. and Stoehr, T. (2021) A Miniature Pig Model of Pharmacological Tolerance to Long-Term Sedation with the Intravenous Benzodiazepines; Midazolam and Remimazolam. European Journal of Pharmacology, 896, Article ID: 173886. [Google Scholar] [CrossRef] [PubMed]
[79] 陈霞, 万云芳, 顾珍梅, 等. B超引导下神经阻滞在临床麻醉中的应用效果评价[J]. 基层医学论坛, 2023, 27(35): 24-26. [Google Scholar] [CrossRef
[80] 潘军里, 徐凯, 黄云萍. 瑞马唑仑镇静辅助臂丛神经阻滞在急诊手外伤手术中的应用[J]. 江苏医药, 2022, 48(11): 1163-1165. [Google Scholar] [CrossRef
[81] 宋尧, 覃禹翱, 夏雪, 等. 瑞马唑仑与右美托咪定在超声引导臂丛神经阻滞断指再植术中的麻醉效果比较[J]. 实用医学杂志, 2023, 39(24): 3243-3248.
[82] 龚廷, 薛佩彤, 刘颖, 等. 瑞马唑仑与右美托咪定在老年关节置换术中镇静效果的比较[J]. 湖北医药学院学报, 2023, 42(6): 637-641. [Google Scholar] [CrossRef
[83] 赵建华, 李双江, 李梅, 等. 脑氧饱和度监测联合瑞马唑仑麻醉对老年关节置换术患者术后谵妄及血清水平的影响[J]. 川北医学院学报, 2023, 38(12): 1680-1684.
[84] 张秋莹, 李立明. 瑞马唑仑复合腰丛-坐骨神经联合阻滞对老年股骨粗隆间骨折手术患者的影响[J]. 河南医学研究, 2023, 32(24): 4517-4520.