儿童迁延性细菌性支气管炎治疗的研究进展
Research Progress in the Treatment of Protracted Bacterial Bronchitis in Children
DOI: 10.12677/acm.2024.1441245, PDF,   
作者: 任小宏, 代继宏*：重庆医科大学附属儿童医院呼吸科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿科学重庆市重点实验室，重庆
关键词: 儿童；迁延性细菌性支气管炎；慢性咳嗽；Children； Protracted Bacterial Bronchitis； Chronic Cough
摘要: 儿童迁延性细菌性支气管炎(Protracted Bacterial Bronchitis, PBB)是一种常见的呼吸道感染性疾病，主要由细菌感染引起，一些患儿会出现症状持续时间延长、反复发作及影响生活质量等问题。近年来，随着分子生物学、免疫学和微生物学等领域的不断发展，对于儿童PBB的治疗研究也取得了一系列重要进展，通过对患儿呼吸道微生物组的深入研究，揭示了其微生物组成和变化规律，为个体化治疗提供了新的思路和方法。本文旨在对儿童迁延性细菌性支气管炎治疗的研究进展进行系统性的综述和分析，以期为临床实践提供更为科学和有效的指导。
Abstract: Protracted bacterial bronchitis (PBB) in children is a common respiratory infectious disease, which is mainly caused by bacterial infection. Some children may have problems such as prolonged symptom duration, recurrent attacks and impact on quality of life. In recent years, with the continuous development of molecular biology, immunology, and microbiology, a series of important progress has been made in the treatment research of pediatric PBB. Through in-depth research on the respiratory microbiome of pediatric patients, the microbial composition and changes have been revealed, providing new ideas and methods for personalized treatment. This article aims to provide a systematic review and analysis of the research progress in the treatment of protracted bacterial bronchitis in children, in order to provide more scientific and effective guidance for clinical practice.
文章引用：任小宏, 代继宏. 儿童迁延性细菌性支气管炎治疗的研究进展[J]. 临床医学进展, 2024, 14(4): 1923-1927. https://doi.org/10.12677/acm.2024.1441245

参考文献

[1] Chang, A.B., Upham, J.W., Masters, I.B., et al. (2016) Protracted Bacterial Bronchitis: The Last Decade and the Road Ahead. Pediatric Pulmonology, 51, 225-242. [Google Scholar] [CrossRef] [PubMed]
[2] Zhang, X., Wu, X. and Nong, G. (2020) Update on Protracted Bacterial Bronchitis in Children. Italian Journal of Pediatrics, 46, Article No. 38. [Google Scholar] [CrossRef] [PubMed]
[3] De Vries, J.J.V., Chang, A.B. and Marchant, J.M. (2018) Comparison of Bronchoscopy and Bronchoalveolar Lavage Findings in Three Types of Suppurative Lung Disease. Pediatric Pulmonology, 53, 467-474. [Google Scholar] [CrossRef] [PubMed]
[4] 管栋, 王晓丽, 李海燕, 郑兴厂. 青岛地区102例儿童迁延性细菌性支气管炎临床特征分析[J]. 中国小儿急救医学, 2021, 28(11): 968-971.
[5] 李银, 谢晓虹, 任洛, 刘恩梅. 儿童迁延性细菌性支气管炎30例临床特征及随访分析[J]. 中华实用儿科临床杂志, 2017, 32(16): 1231-1234.
[6] 范立东, 李志军, 马增光. 阿莫西林克拉维酸钾联合枳桔二陈汤治疗儿童迁延性细菌性支气管炎的效果观察及对炎性因子、免疫功能的影响[J]. 临床误诊误治, 2020, 33(10): 49-52.
[7] 张建琴, 迟磊. 儿童迁延性细菌性支气管炎的诊治进展[J]. 中国中西医结合儿科学, 2020, 12(2): 119-124.
[8] 李嫦嫦, 董琳, 夏永强, 张海邻, 胡晓光, 郑仰明. 迁延性细菌性支气管炎的病例对照分析[J]. 温州医科大学学报, 2018, 48(11): 837-841.
[9] Morice, A.H., Millqvist, E., Bieksiene, K., et al. (2020) ERS Guidelines on the Diagnosis and Treatment of Chronic Cough in Adults and Children. European Respiratory Journal, 55, Article ID: 1901136. [Google Scholar] [CrossRef] [PubMed]
[10] Gross-Hodge, E., Carroll, W.D., Rainford, N., et al. (2020) Duration of Initial Antibiotic Course Is Associated with Recurrent Relapse in Protracted Bacterial Bronchitis. Archives of Disease in Childhood, 105, 1111-1113. [Google Scholar] [CrossRef] [PubMed]
[11] Ruffles, T.J.C., Goyal, V., Marchant, J.M., et al. (2021) Duration of Amoxicillin-Clavulanate for Protracted Bacterial Bronchitis in Children (DACS): A Multi-Centre, Double Blind, Randomised Controlled Trial. The Lancet Respiratory Medicine, 9, 1121-1129. [Google Scholar] [CrossRef] 
[12] 沈锦霞, 徐丽丹. 槐杞黄颗粒治疗儿童迁延性细菌性支气管炎的临床研究[J]. 浙江医学, 2022, 44(8): 855-858.
[13] 侯凡, 闫晓宇, 丁樱, 等. 内托法辨治儿童迁延性细菌性支气管炎[J]. 中医学报, 2023, 38(2): 264-267.
[14] 傅大干, 李海霞, 周伟, 等. 细菌溶解产物防治儿童迁延性细菌性支气管炎疗效研究[J]. 临床肺科杂志, 2022, 27(9): 1312-1316.
[15] 傅大干, 汪纯权, 周伟. 吸入乙酰半胱氨酸佐治儿童迁延性细菌性支气管炎的疗效研究[J]. 临床肺科杂志, 2020, 25(9): 1351-1354.
[16] 薛晋玲, 任晓晴. 头孢曲松联合乙酰半胱氨酸治疗儿童迁延性细菌支气管炎效果及对痰液黏稠度、GATA3、T-Bet的影响[J]. 解放军医药杂志, 2022, 34(5): 45-48.
[17] Priftis, K.N., Litt, D., Manglani, S., et al. (2013) Bacterial Bronchitis Caused by Streptococcus Pneumoniae and Nontypable Haemophilus Influenzae in Children: The Impact of Vaccination. Chest, 143, 152-157. [Google Scholar] [CrossRef] [PubMed]
[18] Ruffles, T.J.C., Marchant, J.M., Masters, I.B., et al. (2021) Outcomes of Protracted Bacterial Bronchitis in Children: A 5-Year Prospective Cohort Study. Respirology, 26, 241-248. [Google Scholar] [CrossRef] [PubMed]
[19] Wurzel, D.F., Marchant, J.M., Yerkovich, S.T., et al. (2016) Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bronchiectasis. Chest, 150, 1101-1108. [Google Scholar] [CrossRef] [PubMed]

为你推荐