重组人脑利钠肽的临床应用进展
Application Progress of Recombinant Human Brain Natriuretic Peptide in Clinical Practice
DOI: 10.12677/acm.2024.1441330, PDF,  被引量   
作者: 刘启俊, 向明钧：吉首大学医学院，湖南 吉首；吕青山*：永州市中心医院心血管内科，湖南 永州
关键词: 重组人脑利钠肽；心力衰竭；综述；Recombinant Human Brain Natriuretic Peptide； Heart Failure； Summarize
摘要: 重组人脑利钠肽(Recombinant Human Brain Natriuretic Peptide, rhBNP)是通过人工重组技术合成的一种外源性肽，可以发挥与内源性脑钠肽(Brain Natriuretic Peptide, BNP)相似生理作用，如促进肾脏排水排钠、扩张血管降低血压、减少心脏前后负荷、抑制肾上腺素系统从而延缓心肌重构和维持血流动力学稳定。自从rhBNP被纳入到心力衰竭防治指南以来，国内外对于其的研究不断加深，本文将简要介绍rhBNP的最新研究动态，以期为临床治疗提供借鉴。
Abstract: Recombinant human brain natriuretic peptide (rhBNP) is an exogenous peptide synthesized through recombinant technology that can exert physiological effects similar to endogenous brain natriuretic peptide (BNP). These effects include promoting renal water and sodium excretion, dilating blood vessels to lower blood pressure, reducing cardiac preload and afterload, inhibiting the adrenergic system to delay myocardial remodeling, and maintaining hemodynamic stability. Since the inclusion of rhBNP in the guidelines for the prevention and treatment of heart failure, research on it has deepened both domestically and internationally. This article will briefly introduce the latest research dynamics of rhBNP, aiming to provide a reference for clinical treatment.
文章引用：刘启俊, 向明钧, 吕青山. 重组人脑利钠肽的临床应用进展[J]. 临床医学进展, 2024, 14(4): 2573-2577. https://doi.org/10.12677/acm.2024.1441330

参考文献

[1] Kourek, C., Briasoulis, A., Giamouzis, G., et al. (2023) Lyophilized Recombinant Human Brain Natriuretic Peptide: A Promising Therapy in Patients with Chronic Heart Failure. World Journal of Clinical Cases, 11, 8603-8605. [Google Scholar] [CrossRef] [PubMed]
[2] Burley, D.S. and Baxter, G.F. (2007) B-Type Natriuretic Peptide at Early Reperfusion Limits Infarct Size in the Rat Isolated Heart. Basic Research in Cardiology, 102, 529-541. [Google Scholar] [CrossRef] [PubMed]
[3] 许洋. 重组人脑利钠肽对体外循环心脏术后心肾保护作用的Meta分析[D]: [硕士学位论文]. 太原: 山西医科大学, 2022.
[4] Dobrev, D., Aguilar, M., Heijman, J., et al. (2019) Postoperative Atrial Fibrillation: Mechanisms, Manifestations and Management. Nature Reviews Cardiology, 16, 417-436. [Google Scholar] [CrossRef] [PubMed]
[5] Kalra, R., Parcha, V., Patel, N., et al. (2020) Implications of Atrial Fibrillation among Patients with Atherosclerotic Cardiovascular Disease Undergoing Noncardiac Surgery. American Journal of Cardiology, 125, 1836-1844. [Google Scholar] [CrossRef] [PubMed]
[6] Wei, Y.Y., Zhang, Q., Chi, H.H., et al. (2023) Effects of Recombinant Human Brain Natriuretic Peptide on Atrial Fibrillation after Coronary Artery Bypass Grafting. Journal of Cardiovascular Pharmacology, 81, 63-69. [Google Scholar] [CrossRef] 
[7] 申恂, 崔江漫, 周松, 等. 注射用重组人脑利钠肽对常规治疗无效的心力衰竭伴房颤患者血清Gal-3、CTGF水平的影响及其与房颤复发的相关性研究[J]. 药物评价研究, 2022, 45(1): 124-131.
[8] Van Deursen Vincent, M., Hernandez, A.F., Stebbins, A., et al. (2014) Nesiritide, Renal Function, and Associated Outcomes during Hospitalization for Acute Decompensated Heart Failure: Results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF). Circulation, 130, 958-965. [Google Scholar] [CrossRef] 
[9] 胡星, 潘传亮, 刘剑萍. 新活素静脉泵入对冠状动脉搭桥术后患者急性肾损伤的防治作用观察[J]. 山东医药, 2017, 57(39): 71-73.
[10] Wang, Z.Y., Wei, Y.Y., Chen, J.Y., et al. (2022) Effect of Recombinant Human Brain Natriuretic Peptide on Acute Kidney Injury after Coronary Artery Bypass Grafting: A Retrospective Comparative Cohort Study. Annals of Translational Medicine, 10, 973. [Google Scholar] [CrossRef] [PubMed]
[11] 冯俊, 余世成, 孙召金, 等. 重组人脑利钠肽对老年急性心肌梗死患者直接介入术后预防造影剂肾病的保护作用[J]. 中华老年心脑血管病杂志, 2021, 23(5): 487-490.
[12] 赵玲, 李凤德, 宋俊迎, 王琼, 张慧晶, 马高峰, 尚艳菲. 重组人脑利钠肽用药时机对急性心肌梗死患者PCI术后的疗效及主要心血管不良事件的影响[J]. 中国医院用药评价与分析, 2023, 23(9): 1071-1074 1078.
[13] Wang, B.S., Xu, H., Li, C.Q., et al. (2021) Analysis of the Effect of Lyophilized Recombinant Human Brain Natriuretic Peptide on Endothelial Function in Patients with Acute Myocardial Infarction. Pakistan Journal of Medical Sciences, 37, 99-103. [Google Scholar] [CrossRef] [PubMed]
[14] Haddad, H., Bergeron, S., Ignaszewski, A., et al. (2020) Canadian Real-World Experience of Using Sacubitril/Valsartan in Patients with Heart Failure with Reduced Ejection Fraction: Insight from the PARASAIL Study. CJC Open, 2, 344-353. [Google Scholar] [CrossRef] [PubMed]
[15] 冠心病合理用药指南[J]. 中国医学前沿杂志(电子版), 2016, 8(6): 19-108.
[16] O’Connor, C.M., Starling, R.C., Hernandez, A.F., et al. (2011) Effect of Nesiritide in Patients with Acute Decompensated Heart Failure. The New England Journal of Medicine, 365, 32-43. [Google Scholar] [CrossRef] 
[17] Zhu, X.Q., Hong, H.S., Lin, X.H., et al. (2014) Changes in Cardiac Aldosterone and Its Synthase in Rats with Chronic Heart Failure: An Intervention Study of Long-Term Treatment with Recombinant Human Brain Natriuretic Peptide. Brazilian Journal of Medical and Biological Research, 47, 646-654. [Google Scholar] [CrossRef] [PubMed]
[18] Li, F., Li, H., Luo, R., et al. (2023) Lyophilized Recombinant Human Brain Natriuretic Peptide for Chronic Heart Failure: Effects on Cardiac Function and Inflammation. World Journal of Clinical Cases, 11, 6066-6072. [Google Scholar] [CrossRef] [PubMed]
[19] Yang, J., Zhang, L.B., Guo, M., et al. (2023) Effects of Recombinant Human Brain Natriuretic Peptide Combined with Tolvaptan on Cardiac and Renal Function and Serum Inflammatory Factors in Patients with Severe Heart Failure. Medicine (Baltimore), 102, E35900. [Google Scholar] [CrossRef] 
[20] 魏秀春, 颜廷卿, 代红力, 等. rhBNP治疗AHF的临床疗效及对血流动力学及炎症因子的影响[J]. 重庆医学, 2017, 46(27): 3798-3800.
[21] Yang, P. and Han, W. (2020) Role of Recombinant Human Brain Natriuretic Peptide Combined with Sodium Nitroprusside in Improving Quality of Life and Cardiac Function in Patients with Acute Heart Failure. Experimental and Therapeutic Medicine, 20, 261-268. [Google Scholar] [CrossRef] [PubMed]
[22] 周波, 于长青, 闫庆凯, 等. 左西孟旦联合重组人脑利钠肽治疗急性心力衰竭的临床效果研究[J]. 重庆医学, 2024, 53(5): 700-706.

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