腹腔镜下食管裂孔疝修补术后与体重、血清Ghrelin、IL-8水平变化研究进展

Research Progress on Changes in Body Weight, Serum Ghrelin, and IL-8 Levels after Laparoscopic Repair of Esophageal Hiatal Hernia

摘要: 腹腔镜下食管裂孔疝修补术作为治疗胃食管逆流病变的主要手术方法之一，近年来备受关注。本文旨在综述腹腔镜下食管裂孔疝修补术后与体重、血清Ghrelin、IL-8等指标变化的研究进展。研究发现，术后体重变化与患者原发疾病、手术方式及术后生活方式等多因素相关。在手术后期，部分患者体重出现下降趋势，但这一变化并非普遍存在，部分患者体重稳定或略有增加。此外，术后血清Ghrelin水平的变化对患者的食欲和体重恢复具有一定影响，但其具体机制仍有待深入研究。IL-8作为一种炎症介质，在腹腔镜下食管裂孔疝修补术后的变化也备受关注。研究表明，术后IL-8水平可能与术后并发症的发生及愈合情况相关，但其具体作用机制尚不清楚。综上所述，腹腔镜下食管裂孔疝修补术后的体重变化、血清Ghrelin和IL-8水平的变化对患者的术后康复具有一定的影响，但其确切机制仍需进一步深入研究。

Abstract: Laparoscopic repair of esophageal hiatal hernia, as one of the main surgical methods for treating gastroesophageal reflux disease, has received much attention in recent years. This article aims to review the research progress on changes in body weight, serum Ghrelin, IL-8 and other indicators after laparoscopic repair of esophageal hiatal hernia. Research has found that postoperative weight changes are related to multiple factors such as the patient’s primary disease, surgical approach, and postoperative lifestyle. In the later stage of surgery, some patients show a trend of weight loss, but this change is not universal, and some patients have stable or slightly increased weight. In addition, changes in postoperative serum Ghrelin levels have a certain impact on patient appetite and weight recovery, but the specific mechanism still needs further research. The changes of IL-8, as an inflammatory mediator, after laparoscopic repair of esophageal hiatal hernia have also received much attention. Research has shown that postoperative IL-8 levels may be related to the occurrence and healing of postoperative complications, but the specific mechanism of action is still unclear. In summary, the changes in body weight, serum Ghrelin and IL-8 levels after laparoscopic repair of esophageal hiatal hernia have a certain impact on the postoperative recovery of patients, but the exact mechanism still needs further in-depth research.