早发性卵巢功能不全远期健康后果及管理注意事项
Long-Term Health Consequences and Management Considerations of Premature Ovarian Insufficiency
DOI: 10.12677/acm.2024.1441342, PDF,   
作者: 李 欣:延安大学医学院,陕西 延安;岳红云*:延安大学附属医院生殖中心,陕西 延安
关键词: 早发性卵巢功能不全激素替代治疗健康管理Premature Ovarian Insufficiency Hormone Replacement Therapy Health Management
摘要: 早发性卵巢功能不全是指女性在40岁以前卵巢功能减退的临床综合征。闭经、促性腺激素升高和雌激素缺乏三种情况不仅影响到患者生殖健康,而且导致患者内分泌功能紊乱,远期可能诱发心血管疾病、骨质疏松、认知功能减退及泌尿生殖系统疾病等,严重威胁女性健康。因此,对早发性卵巢功能不全患者进行持续的健康管理十分重要。
Abstract: Premature ovarian insufficiency is a clinical syndrome of decreased ovarian function in women before the age of 40 years. Amenorrhea, elevated gonadotropin and estrogen deficiency not only affect the reproductive health of patients, but also lead to endocrine dysfunction. In the long term, they may induce cardiovascular disease, osteoporosis, cognitive decline and urogenital system diseases, which seriously threaten the health of women. Therefore, continuous health management of patients with premature ovarian insufficiency is very important.
文章引用:李欣, 岳红云. 早发性卵巢功能不全远期健康后果及管理注意事项[J]. 临床医学进展, 2024, 14(4): 2656-2661. https://doi.org/10.12677/acm.2024.1441342

参考文献

[1] Webber, L., Davies, M., Anderson, R., et al. (2016) ESHRE Guideline: Management of Women with Premature Ovarian Insufficiency. Human Reproduction, 31, 926-937. [Google Scholar] [CrossRef] [PubMed]
[2] 陈子江, 田秦杰, 乔杰, 等. 早发性卵巢功能不全的临床诊疗中国专家共识[J]. 中华妇产科杂志, 2017, 52(9): 577-581.
[3] Golezar, S., Ramezani Tehrani, F., Khazaei, S., et al. (2019) The Global Prevalence of Primary Ovarian Insufficiency and Early Menopause: A Meta-Analysis. Climacteric, 22, 403-411. [Google Scholar] [CrossRef] [PubMed]
[4] Podfigurna, A. and Męczekalski, B. (2018) Cardiovascular Health in Patients with Premature Ovarian Insufficiency. Management of Long-Term Consequences. Przegląd Menopauzalny, 17, 109-111. [Google Scholar] [CrossRef] [PubMed]
[5] Xu, X., Jones, M. and Mishra, G.D. (2020) Age at Natural Menopause and Development of Chronic Conditions and Multimorbidity: Results from an Australian Prospective Cohort. Human Reproduction, 35, 203-211. [Google Scholar] [CrossRef] [PubMed]
[6] Nappi, R.E., Chedraui, P., Lambrinoudaki, I., et al. (2022) Menopause: A Cardiometabolic Transition. The Lancet Diabetes & Endocrinology, 10, 442-456. [Google Scholar] [CrossRef
[7] Van Lennep, J.E.R., Heida, K.Y., Bots, M.L., et al. (2016) Cardiovascular Disease Risk in Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis. European Journal of Preventive Cardiology, 23, 178-186. [Google Scholar] [CrossRef] [PubMed]
[8] Honigberg, M.C., Zekavat, S.M., Aragam, K., et al. (2019) Association of Premature Natural and Surgical Menopause with Incident Cardiovascular Disease. JAMA, 322, 2411-2421. [Google Scholar] [CrossRef] [PubMed]
[9] Stefil, M., Kotalczyk, A., Blair, J.C., et al. (2023) Cardiovascular Considerations in Management of Patients with Turner Syndrome. Trends in Cardiovascular Medicine, 33, 150-158. [Google Scholar] [CrossRef] [PubMed]
[10] Silberbach, M., Roos-Hesselink, J.W., Andersen, N.H., et al. (2018) Cardiovascular Health in Turner Syndrome: A Scientific Statement from the American Heart Association. Circulation: Genomic and Precision Medicine, 11, e000048. [Google Scholar] [CrossRef
[11] Daan, N.M.P., Muka, T., Koster, M.P.H., et al. (2016) Cardiovascular Risk in Women with Premature Ovarian Insufficiency Compared to Premenopausal Women at Middle Age. The Journal of Clinical Endocrinology & Metabolism, 101, 3306-3315. [Google Scholar] [CrossRef] [PubMed]
[12] 中华医学会妇产科学分会绝经学组. 早发性卵巢功能不全的临床诊疗专家共识(2023版)[J]. 中华妇产科杂志, 2023, 58(10): 721-728.
[13] Kalantaridou, S.N., Naka, K.K., Papanikolaou, E., et al. (2004) Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy. The Journal of Clinical Endocrinology & Metabolism, 89, 3907-3913. [Google Scholar] [CrossRef] [PubMed]
[14] Ostberg, J.E., Storry, C., Donald, A.E., et al. (2007) A Dose-Response Study of Hormone Replacement in Young Hypogonadal Women: Effects on Intima Media Thickness and Metabolism. Clinical Endocrinology, 66, 557-564. [Google Scholar] [CrossRef] [PubMed]
[15] Meczekalski, B., Niwczyk, O., Bala, G. and Szeliga, A. (2023) Managing Early Onset Osteoporosis: The Impact of Premature Ovarian Insufficiency on Bone Health. Journal of Clinical Medicine, 12, Article 4042. [Google Scholar] [CrossRef] [PubMed]
[16] Khosla, S., Oursler, M.J. and Monroe, D.G. (2012) Estrogen and the Skeleton. Trends in Endocrinology & Metabolism, 23, 576-581. [Google Scholar] [CrossRef] [PubMed]
[17] Szeliga, A., Maciejewska-Jeske, M. and Męczekalski, B. (2018) Bone Health and Evaluation of Bone Mineral Density in Patients with Premature Ovarian Insufficiency. Przegląd Menopauzalny, 17, 112-116. [Google Scholar] [CrossRef] [PubMed]
[18] Yoshida, T., Takahashi, K., Yamatani, H., et al. (2011) Impact of Surgical Menopause on Lipid and Bone Metabolism. Climacteric, 14, 445-452. [Google Scholar] [CrossRef] [PubMed]
[19] Sullivan, S.D., Lehman, A., Thomas, F., et al. (2015) Effects of Self-Reported Age at Nonsurgical Menopause on Time to First Fracture and Bone Mineral Density in the Women’s Health Initiative Observational Study. Menopause, 22, 1035-1044. [Google Scholar] [CrossRef
[20] Nguyen, H.H., Milat, F. and Vincent, A.J. (2021) New Insights into the Diagnosis and Management of Bone Health in Premature Ovarian Insufficiency. Climacteric, 24, 481-490. [Google Scholar] [CrossRef] [PubMed]
[21] Shah, S., Nguyen, H.H. and Vincent, A.J. (2018) Care of the Adult Woman with Turner Syndrome. Climacteric, 21, 428-436. [Google Scholar] [CrossRef] [PubMed]
[22] 雷小敏, 谭新沙. 早发性卵巢功能不全对骨代谢影响[J]. 中国实用妇科与产科杂志, 2018, 34(3): 245-248.
[23] Podfigurna, A., Maciejewska-Jeske, M., Nadolna, M., et al. (2020) Impact of Hormonal Replacement Therapy on Bone Mineral Density in Premature Ovarian Insufficiency Patients. Journal of Clinical Medicine, 9, Article 3961. [Google Scholar] [CrossRef] [PubMed]
[24] Ha, J., Park, S.-S., Park, S., et al. (2020) Effects of Hormone Replacement Therapy on Bone Mass after Allogeneic Hematopoietic Stem Cell Transplantation. The Journal of Clinical Endocrinology & Metabolism, 105, e3267-e3276. [Google Scholar] [CrossRef] [PubMed]
[25] Rocca, W.A., Bower, J.H., Maraganore, D.M., et al. (2008) Increased Risk of Parkinsonism in Women Who Underwent Oophorectomy before Menopause. Neurology, 70, 200-209. [Google Scholar] [CrossRef] [PubMed]
[26] Ryan, J., Scali, J., Carrière, I., et al. (2014) Impact of a Premature Menopause on Cognitive Function in Later Life. BJOG: An International Journal of Obstetrics & Gynaecology, 121, 1729-1739. [Google Scholar] [CrossRef] [PubMed]
[27] Gibson-Helm, M., Teede, H. and Vincent, A. (2014) Symptoms, Health Behavior and Understanding of Menopause Therapy in Women with Premature Menopause. Climacteric, 17, 666-673. [Google Scholar] [CrossRef] [PubMed]
[28] Dennerstein, L., Koochaki, P., Barton, I., et al. (2006) Hypoactive Sexual Desire Disorder in Menopausal Women: A Survey of Western European Women. The Journal of Sexual Medicine, 3, 212-222. [Google Scholar] [CrossRef] [PubMed]
[29] Weber, M.T., Maki, P.M. and Mcdermott, M.P. (2014) Cognition and Mood in Perimenopause: A Systematic Review and Meta-Analysis. The Journal of Steroid Biochemistry and Molecular Biology, 142, 90-98. [Google Scholar] [CrossRef] [PubMed]
[30] Benetti-Pinto, C.L., De Almeida, D.M.B. and Makuch, M.Y. (2011) Quality of Life in Women with Premature Ovarian Failure. Gynecological Endocrinology, 27, 645-649. [Google Scholar] [CrossRef] [PubMed]