基于肠道菌群探讨中医药防治高血压合并2型糖尿病

To Explore the Prevention and Treatment of Hypertension Complicated with Type 2 Diabetes Mellitus by Traditional Chinese Medicine Based on Intestinal Flora

摘要: 高血压是以体循环动脉压升高为主要临床表现的心血管综合征，是临床上常见的慢性疾病。高血压和2型糖尿病是两种互相影响的代谢性疾病。高血压是糖尿病的危险因素，并且通常先于糖尿病的发展，二者共存会对多器官造成严重损害，而发生心血管疾病的风险更是普通人群的4~8倍。肠道菌群在新生儿出生后便存在于肠道中，主要包括厚壁菌门和拟杆菌门。肠道微生物参与人体代谢时会产生氧化三甲胺、脂多糖、短链脂肪酸等物质，这些代谢产物可在肠外发挥一系列作用。高血压及糖尿病的发生发展与肠道微生物密切相关，肠道菌群已成为新的治疗靶点。本文基于肠道菌群探讨中医药对高血压合并2型糖尿病的防治，通过探究并阐明肠道菌群与高血压合并2型糖尿病的相关性，为中医药防治该合并症提供新的思路。

Abstract: Hypertension is a cardiovascular syndrome with elevated systemic arterial pressure as the main clinical manifestation. It is a common chronic disease in clinic. Hypertension and type 2 diabetes are two metabolic diseases that affect each other. Hypertension is a risk factor for diabetes, and usually precedes the development of diabetes. The coexistence of the two can cause serious damage to multiple organs, and the risk of cardiovascular disease is 4 to 8 times higher than that of the general population. Intestinal flora exists in the intestine after birth, mainly including Firmicutes and Bacteroidetes. Intestinal microorganisms produce trimethylamine oxide, lipopolysaccharide, short-chain fatty acids and other substances when they participate in human metabolism. These metabolites can play a series of roles outside the intestine. The occurrence and development of hypertension and diabetes are closely related to intestinal microorganisms, and intestinal flora has become a new therapeutic target. Based on the intestinal flora, this paper discusses the prevention and treatment of hypertension combined with type 2 diabetes mellitus by traditional Chinese medicine. By exploring and clarifying the correlation between intestinal flora and hypertension combined with type 2 diabetes mellitus, it provides new ideas for the prevention and treatment of this complication by traditional Chinese medicine.