血管钙化与血管内皮生长因子的研究进展

Research Progress of Vascular Calcification and Vascular Endothelial Growth Factor

摘要: 血管钙化是心血管系统最常见的血管疾病之一，已经被证实是一个主动的、可调控的、可预防的过程。血管钙化的病理过程类似于骨发育和软骨形成的过程，其核心是平滑肌细胞(vascular smooth muscle cell, VSMC)分化为成骨或软骨细胞，从而导致钙盐的异常沉积。血管内皮生长因子(vascular endothelial growth factor, VEGF)是内皮细胞高度特异性的血管生成因子，VEGF可促进血管内皮细胞增殖迁移、提高血管通透性并加速血管形成。在血管钙化形成过程中，VEGF及其受体表达显著上升。为了阐明VEGF在血管钙化过程中的调控机制，为血管钙化的临床治疗提供新思路，本文将重点就VEGF与血管钙化之间的关系进行综述。

Abstract: Vascular calcification is one of the most common vascular diseases in cardiovascular system, which has been proven to be an active, controllable and preventable process. The pathological process of vascular calcification is similar to the process of bone development and cartilage formation, the core of which is the differentiation of vascular smooth muscle cell (VSMC) into osteoblasts or chondrocytes, which leads to abnormal deposition of calcium salts. Vascular endothelial growth factor (VEGF) is a highly specific angiogenic factor of endothelial cells. VEGF can promote the proliferation and migration of vascular endothelial cells, improve vascular permeability and accelerate the formation of blood vessels. In the process of vascular calcification, the expression of VEGF and its receptor increased significantly. In order to clarify the regulatory mechanism of VEGF in the process of vascular calcification and provide new ideas for clinical treatment of vascular calcification, this article will focus on the relationship between VEGF and vascular calcification.