ETFDH基因在结直肠癌中作用及机制的初步探索与论述

Initial Investigation and Dialogue on the Function and Mechanism of ETFDH Gene in CRC

摘要: 电子转移黄素蛋白脱氢酶(Electron Transferring Flavoprotein Dehydrogenase, ETFDH)编码的ETF-QO蛋白是一种定位于线粒体内膜的蛋白质。它介导了从黄素蛋白脱氢酶到泛醌池的电子传输，在氧化呼吸链电子转移系统中起着重要作用。ETFDH基因突变可导致常染色体隐性遗传病——多酰基辅酶A脱氢酶缺乏症(MADD)。近年来，有研究表明ETFDH基因在多种肿瘤中也发挥重要作用，在肝癌中可作为生存期评估的独立预测因子。本综述概述了ETFDH基因在肿瘤组织中的表达特点、在肿瘤细胞代谢中的特点、在结直肠癌中的作用特点、与肿瘤免疫的相关性以及其在肿瘤预后及生存期评估中的作用。在既往研究的基础上进一步探寻ETFDH基因在结直肠癌中的生物学作用及在肿瘤免疫微环境中的作用特点，从而探寻结直肠癌治疗及预后评估的新方向。

Abstract: The electron transfer flavoprotein-quinone oxidoreductase (ETF-QO), encoded by the Electron Transfer Flavoprotein Dehydrogenase (ETFDH), is a protein found in the inner mitochondrial membrane. It mediates electron transport from flavin protein dehydrogenase to ubiquinone pool and plays an important role in the electron transfer system of the oxidative respiratory chain. The mutation of the ETFDH can result in MADD, an autosomal recessive genetic disorder. Recent studies have revealed that the ETFDH gene also plays a significant role in various tumors, and can serve as an independent prognostic factor for survival in liver cancer assessments. This review provides an overview of the expression patterns of the ETFDH gene in tumor tissues, its involvement in tumor cell metabolism, its impact on colorectal cancer, its association with tumor immunity, and its contribution to tumor prognosis and survival assessment. Building upon existing research, the study delves into the ETFDH gene’s role in colorectal cancer and its influence on the tumor immune microenvironment, offering novel insights for disease management and prognosis prediction in colorectal cancer.