儿童幽门螺杆菌感染治疗现状及进展

Current Status and Progress in the Treatment of Helicobacter pylori Infection in Children

摘要: 随着幽门螺杆菌(Helicobacter pylori, H. pylori)在儿童中感染率的持续关注，其治疗方法和感染后果引起了广泛的研究兴趣。本文综述分析了关于儿童H. pylori感染治疗及相关健康影响的研究文献。研究集中在H. pylori与儿童健康关联性，全球流行病学特征，与其他疾病风险的关联，以及菌群感染的症状和治疗响应上。本文将探讨根除H. pylori对改善功能性消化不良症状的重要性，以及抗生素耐药性等问题。综合现有研究表明，序贯疗法和三联疗法是常用的治疗胃溃疡并发的方案，而抗生素靶基因突变与药物耐药性的关系仍在研究之中。总体看来，研究强调了针对不同地区、不同亚型H. pylori感染的个体化治疗策略的重要性。未来研究需关注治疗方案的优化以及耐药性的长期监测。

Abstract: With continued concern about the rate of infection of Helicobacter pylori (H. pylori) in children, its treatment and the consequences of infection have attracted extensive research interest. This paper reviews the literature on the treatment of H. pylori infection in children and its related health effects. Studies have focused on H. pylori’s association with child health, global epidemiological characteristics, associations with risk of other diseases, and symptoms and treatment responses to bacterial infection. This article will explore the importance of eradicating H. pylori in improving symptoms of functional dyspepsia, as well as issues such as antibiotic resistance. Summary of existing studies shows that sequential therapy and triple therapy are commonly used to treat gastric ulcer complications, but the relationship between antibiotic target gene mutation and drug resistance is still under study. Overall, the study highlights the importance of individualized treatment strategies for different regions and subtypes of H. pylori infection. Future studies need to focus on the optimization of treatment protocols and long-term monitoring of drug resistance.