靶向测序技术在临床中的运用
The Application of Targeted Sequencing Technology in Clinical Practice
DOI: 10.12677/acm.2024.1451482, PDF,   
作者: 刘金峰：赣南医科大学第一临床医学院，江西 赣州；钟一鸣：赣南医科大学第一附属医院心血管内科，江西 赣州
关键词: 靶向测序；下一代测序；精准医疗；基因变异；Targeted Sequencing； Next-Generation Sequencing； Precision Medicine； Gene Mutation
摘要: 靶向测序技术在过去二十年得到迅猛发展，其在精准医疗领域已得到广泛的临床应用。本文详细讨论了靶向测序方法的技术方面，包括PCR富集、杂交捕获和选择性环化等，并深入分析了其在临床肿瘤学、产前筛查、遗传病、传染病和药物反应分析等方面的应用。此外，本文还着重指出了该领域面临的挑战和新兴趋势，如数据分析、成本效益和新靶向技术的发展。这篇文章提供了靶向测序技术在现代医学中的影响和潜力的详细概览。
Abstract: Targeted sequencing technology has experienced rapid development over the past two decades and has been widely applied in the field of precision medicine. This article discusses in detail the technical aspects of targeted sequencing methods, including PCR enrichment, hybrid capture, and selective circularization, and deeply analyzes their applications in clinical oncology, prenatal screening, genetic diseases, infectious diseases, and drug response analysis. Additionally, this paper highlights the challenges and emerging trends in this field, such as data analysis, cost-effectiveness, and the development of new targeted technologies, providing a comprehensive overview of the impact and potential of targeted sequencing in modern medicine.
文章引用：刘金峰, 钟一鸣. 靶向测序技术在临床中的运用[J]. 临床医学进展, 2024, 14(5): 713-719. https://doi.org/10.12677/acm.2024.1451482

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