ALBI分级在肝癌治疗预后评价中的应用研究进展
Research Progress on the Application of ALBI Grade in Prognostic Evaluation of Liver Cancer Treatment
摘要: 目前临床上大多使用Child-Pugh分级来评估肝癌患者的肝功能及治疗相关的预后预测，但由于Child-Pugh分级评价指标中的腹水及白蛋白水平存在关联，且腹水及肝性脑病分度存在较大主观性，降低了评分的客观性和精确性。ALBI分级是Philip J. Johnson等人于2014年提出的评估肝功能的新方法，是一个仅包含白蛋白和胆红素两项客观指标的统计模型。本文就近年来ALBI分级在肝癌患者疗效和预后的评估、ALBI的改良及与其他预后评分的结合予以总结并进行综述。
Abstract: In clinical practice, the Child-Pugh grade is widely used to assess liver function and predict treatment-related prognosis in patients with hepatocellular carcinoma. However, the objectivity and accuracy of the Child-Pugh grade are compromised due to the correlation between ascites and albumin levels in the evaluation criteria, and the significant subjectivity in grading ascites and hepatic encephalopathy. The ALBI (Albumin-Bilirubin) grade, proposed by Philip J. Johnson and colleagues in 2014, is a novel method for assessing liver function, featuring a statistical model that includes only two objective indicators: albumin and bilirubin. This article summarizes and reviews the application of ALBI grading in the evaluation of therapeutic efficacy and prognosis in hepatocellular carcinoma in recent years, the modifications of ALBI, and its combination with other prognostic scores.
文章引用：唐淑瑶, 石统东. ALBI分级在肝癌治疗预后评价中的应用研究进展[J]. 临床医学进展, 2024, 14(5): 933-939. https://doi.org/10.12677/acm.2024.1451509

参考文献

[1] Sung, H., Ferlay, J., Siegel, R.L., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. [Google Scholar] [CrossRef] [PubMed]
[2] Han, B., Zheng, R., Zeng, H., et al. (2024) Cancer Incidence and Mortality in China, 2022. Journal of the National Cancer Center, 4, 47-53. [Google Scholar] [CrossRef] [PubMed]
[3] Johnson, P.J., Berhane, S., Kagebayashi, C., et al. (2015) Assessment of Liver Function in Patients with Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade. Journal of Clinical Oncology, 33, 550-558. [Google Scholar] [CrossRef] 
[4] Maluccio, M. and Covey, A. (2012) Recent Progress in Understanding, Diagnosing, and Treating Hepatocellular Carcinoma. CA: A Cancer Journal for Clinicians, 62, 394-399. [Google Scholar] [CrossRef] [PubMed]
[5] Reig, M., Forner, A., Rimola, J., et al. (2022) BCLC Strategy for Prognosis Prediction and Treatment Recommendation: The 2022 Update. Journal of Hepatology, 76, 681-693. [Google Scholar] [CrossRef] [PubMed]
[6] Ma, X.L., Zhou, J.Y., Gao, X.H., et al. (2016) Application of the Albumin-Bilirubin Grade for Predicting Prognosis after Curative Resection of Patients with Early-Stage Hepatocellular Carcinoma. Clinica Chimica Acta, 462, 15-22. [Google Scholar] [CrossRef] [PubMed]
[7] Amisaki, M., Uchinaka, E., Morimoto, M., et al. (2018) Post-Operative Albumin-Bilirubin Grade Predicts Long-Term Outcomes among Child-Pugh Grade Patients with Hepatocellular Carcinoma after Curative Resection. Hepatobiliary & Pancreatic Diseases International, 17, 502-509. [Google Scholar] [CrossRef] [PubMed]
[8] Wang, Y.Y., Zhong, J.H., Su, Z.Y., et al. (2016) Albumin–Bilirubin versus Child-Pugh Score as a Predictor of Outcome after Liver Resection for Hepatocellular Carcinoma. British Journal of Surgery, 103, 725-734. [Google Scholar] [CrossRef] [PubMed]
[9] Cho, W.R., Hung, C.H., Chen, C.H., et al. (2020) Ability of the Post-Operative ALBI Grade to Predict the Outcomes of Hepatocellular Carcinoma after Curative Surgery. Scientific Reports, 10, Article No. 7290. [Google Scholar] [CrossRef] [PubMed]
[10] 詹一, 倪才方, 仲斌演, 等. ALBI分级在肝细胞癌肝功能评估及预后分层的应用及研究进展[J]. 实用医学杂志, 2023, 39(3): 381-385.
[11] Ho, S.Y., Liu, P.H., Hsu, C.Y., et al. (2018) Prognostic Performance of Ten Liver Function Models in Patients with Hepatocellular Carcinoma Undergoing Radiofrequency Ablation. Scientific Reports, 8, Article No. 843. [Google Scholar] [CrossRef] [PubMed]
[12] Oh, I.S., Sinn, D.H., Kang, T.W., et al. (2017) Liver Function Assessment Using Albumin-Bilirubin Grade for Patients with Very Early-Stage Hepatocellular Carcinoma Treated with Radiofrequency Ablation. Digestive Diseases and Sciences, 62, 3235-3242. [Google Scholar] [CrossRef] [PubMed]
[13] Kao, W.Y., Su, C.W., Chiou, Y.Y., et al. (2017) Hepatocellular Carcinoma: Nomograms Based on the Albumin-Bilirubin Grade to Assess the Outcomes of Radiofrequency Ablation. Radiology, 285, 670-680. [Google Scholar] [CrossRef] [PubMed]
[14] 王哲轩, 王恩鑫, 夏冬东, 等. Child-Pugh评分和ALBI分级预测经肝动脉化疗栓塞治疗不可切除肝细胞癌预后的价值比较[J]. 临床肝胆病杂志, 2020, 36(1): 113-117.
[15] Ho, S.Y., Liu, P.H., Hsu, C.Y., et al. (2017) Prognostic Role of Noninvasive Liver Reserve Markers in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization. PLOS ONE, 12, e0180408. [Google Scholar] [CrossRef] [PubMed]
[16] Zhao, S., Zhang, T., Li, H., et al. (2020) Comparison of Albumin-Bilirubin Grade versus Child-Pugh Score in Predicting the Outcome of Transarterial Chemoembolization for Hepatocellular Carcinoma Using Time-Dependent ROC. Annals of Translational Medicine, 8, Article 538. [Google Scholar] [CrossRef] [PubMed]
[17] Kornberg, A., Witt, U., Schernhammer, M., et al. (2019) the Role of Preoperative Albumin-Bilirubin Grade for Oncological Risk Stratification in Liver Transplant Patients with Hepatocellular Carcinoma. Journal of Surgical Oncology, 120, 1126-1136. [Google Scholar] [CrossRef] [PubMed]
[18] 张瑜, 张珏, 刘现忠, 等. ALBI分级和NLR对HBV相关肝细胞癌患者肝移植预后的影响[J]. 临床肿瘤学杂志, 2021, 26(1): 55-60.
[19] Pinato, D.J., Kaneko, T., Saeed, A., et al. (2020) Immunotherapy in Hepatocellular Cancer Patients with Mild to Severe Liver Dysfunction: Adjunctive Role of the ALBI Grade. Cancers, 17, Article 1862. [Google Scholar] [CrossRef] [PubMed]
[20] Campani, C., Bamba-Funck, J., Campion, B., et al. (2023) Baseline ALBI Score and Early Variation of Serum AFP Predicts Outcomes in Patients with HCC Treated by Atezolizumab-Bevacizumab. Liver International, 43, 708-717. [Google Scholar] [CrossRef] [PubMed]
[21] Ueshima, K., Nishida, N., Hagiwara, S., et al. (2019) Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Study. Cancers, 11, Article 952. [Google Scholar] [CrossRef] [PubMed]
[22] Vogel, A., Frenette, C., Sung, M., et al. (2021) Baseline Liver Function and Subsequent Outcomes in the Phase 3 REFLECT Study of Patients with Unresectable Hepatocellular Carcinoma. Liver Cancer, 10, 510-521. [Google Scholar] [CrossRef] [PubMed]
[23] Hiraoka, A., Michitaka, K., Kumada, T., et al. (2017) Validation and Potential of Albumin-Bilirubin Grade and Prognostication in a Nationwide Survey of 46,681 Hepatocellular Carcinoma Patients in Japan: The Need for a More Detailed Evaluation of Hepatic Function. Liver Cancer, 6, 325-336. [Google Scholar] [CrossRef] [PubMed]
[24] Hiraoka, A., Kumada, T., Michitaka, K., et al. (2016) Usefulness of Albumin-Bilirubin Grade for Evaluation of Prognosis of 2584 Japanese Patients with Hepatocellular Carcinoma. Journal of Gastroenterology and Hepatology, 31, 1031-1036. [Google Scholar] [CrossRef] [PubMed]
[25] Müller, L., Hahn, F., Mähringer-Kunz, A., et al. (2021) Refining Prognosis in Chemoembolization for Hepatocellular Carcinoma: Immunonutrition and Liver Function. Cancers, 13, Article 3961. [Google Scholar] [CrossRef] [PubMed]
[26] Kariyama, K., Nouso, K., Hiraoka, A., et al. (2020) EZ-ALBI Score for Predicting Hepatocellular Carcinoma Prognosis. Liver Cancer, 9, 734-743. [Google Scholar] [CrossRef] [PubMed]

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