BDNF/TrkB信号通路在一氧化碳中毒迟发性脑病中的研究进展
Research Progress of BDNF/TrkB Signaling Pathway in Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
摘要: 一氧化碳中毒迟发脑病(DEACMP)的主要症状是认知功能障碍，这导致患者的日常生活能力出现下降，给患者、家庭乃至整个社会带来沉重的负担。目前DEACMP的发病机制不明，尚无特效的治疗方法，因此，明确DEACMP的发病原因并寻找有效的治疗策略已经成为临床研究的焦点。研究表明，DEACMP的发生与BDNF/TrkB信号通路有着紧密的联系。因此本文就近年来BDNF/TrkB信号通路在DEACMP中的研究进行综述。
Abstract: The main symptom of delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is cognitive dysfunction, which leads to the decline of patients’ ability of daily living and brings a heavy burden to patients, families and even the whole society. At present, the pathogenesis of DEACMP is unknown, and there is no specific treatment. Therefore, it has become the focus of clinical research to clarify the pathogenesis of DEACMP and find effective treatment strategies. The research shows that the occurrence of DEACMP is closely related to BDNF/TrkB signal pathway. Therefore, this paper summarizes the research on BDNF/TrkB signal path in DEACMP in recent years.
文章引用：金渊媛, 张军. BDNF/TrkB信号通路在一氧化碳中毒迟发性脑病中的研究进展[J]. 临床医学进展, 2024, 14(5): 1005-1011. https://doi.org/10.12677/acm.2024.1451518

参考文献

[1] Juric, D.M. Suput, D. and Brvar, M. (2016) Hyperbaric Oxygen Preserves Neurotrophic Activity of Carbon Monoxide-Exposed Astrocytes. Toxicology Letters, 253, 1-6. [Google Scholar] [CrossRef] [PubMed]
[2] Barde, Y.A., Edgar, D. and Thoenen, H. (1982) Purification of a New Neurotrophic Factor from Mammalian Brain. The EMBO Journal, 5, 549-553. [Google Scholar] [CrossRef] [PubMed]
[3] Miranda, M., Morici, J.F., Zanoni, M.B., et al. (2019) Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Frontiers in Cellular Neuroscience, 13, Article 472800. [Google Scholar] [CrossRef] [PubMed]
[4] Li, Y., Li, F., Qin, D., et al. (2022) The Role of Brain Derived Neurotrophic Factor in Central Nervous System. Frontiers in Aging Neuroscience, 14, Article 986443. [Google Scholar] [CrossRef] [PubMed]
[5] Lu, B., Nagappan, G. and Lu, Y. (2023) BDNF and Synaptic Plasticity, Cognitive Function, and Dysfunction. In: Lewin, G. and Carter, B., Eds., Neurotrophic Factors, Springer, Berlin, 223-250. [Google Scholar] [CrossRef] [PubMed]
[6] Leal, G., Comprido, D. and Duarte, C.B. (2014) BDNF-Induced Local Protein Synthesis and Synaptic Plasticity. Neuropharmacology, 76, 639-656. [Google Scholar] [CrossRef] [PubMed]
[7] Castrén, E. and Monteggia, L.M. (2021) Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action. Biological Psychiatry, 90, 128-136. [Google Scholar] [CrossRef] [PubMed]
[8] Wei, Z., Liao, J., Qi, F., et al. (2015) Evidence for the Contribution of BDNF-TrkB Signal Strength in Neurogenesis: An Organotypic Study. Neuroscience Letters, 606, 48-52. [Google Scholar] [CrossRef] [PubMed]
[9] Han, M., Zhang, J.C., Huang, X.F. and Hashimoto, K. (2017) Intake of 7, 8-Dihydroxyflavone from Pregnancy to Weaning Prevents Cognitive Deficits in Adult Offspring after Maternal Immune Activation. European Archives of Psychiatry and Clinical Neuroscience, 267, 479-483. [Google Scholar] [CrossRef] [PubMed]
[10] Li, W., Lu, L., Zhu, D., et al. (2022) Gestational Exposure to Fluoride Impairs Cognition in C57 BL/6J Male Offspring Mice via the P-Creb1-BDNF-TrkB Signaling Pathway. Ecotoxicology and Environmental Safety, 239, Article ID: 113682. [Google Scholar] [CrossRef] [PubMed]
[11] Huang, Y., Huang, C. and Yun, W. (2019) Peripheral BDNF/TrkB Protein Expression Is Decreased in Parkinson’s Disease But Not in Essential Tremor. Journal of Clinical Neuroscience, 63, 176-181. [Google Scholar] [CrossRef] [PubMed]
[12] Fontanesi, C., Kvint, S., Frazzitta, G., et al. (2016) Intensive Rehabilitation Enhances Lymphocyte BDNF-TrkB Signaling in Patients with Parkinson’s Disease. Neurorehabilitation and Neural Repair, 30, 411-418. [Google Scholar] [CrossRef] [PubMed]
[13] Gu, Z., Lv, X., Guo, Y., et al. (1970) Total Flavonoids of Cynomorium Songaricum Attenuates Cognitive Defects in an Aβ 1-42-Induced Alzheimer’s Disease Rat Model by Activating BDNF/TrkB Signaling Transduction. NeuroReport, 17, 825-833. [Google Scholar] [CrossRef] 
[14] Zheng, Q., Liu, L., Liu, H., et al. (2019) The Bu Shen Yi Sui Formula Promotes Axonal Regeneration via Regulating the Neurotrophic Factor BDNF/TrkB and the Downstream PI3K/Akt Signaling Pathway. Frontiers in Pharmacology, 10, Article 796. [Google Scholar] [CrossRef] [PubMed]
[15] 袁洁, 高静, 苏凯奇, 等. 电针对脑缺血再灌注损伤诱导的学习记忆障碍大鼠BDNF/TRKB/CREB信号通路和海马突触可塑性的影响[J]. 针刺研究, 2023, 48(9): 843-851.
[16] Huang, S.S., Zhou, B., Zeng, G.X., et al. (2024) Neuroprotective Effect and Mechanism of Butylphthalide after Cerebral Ischemia-Reperfusion Injury in Rats. Folia Neuropathologic, 2, 131-142. [Google Scholar] [CrossRef] [PubMed]
[17] 朱红灿, 岳培建. CO中毒迟发性脑病诊断与治疗中国专家共识[J]. 中国神经免疫学和神经病学杂志, 2021, 28(3): 173-179.
[18] Hara, S., Mizukami, H., Kurosaki, K., et al. (2011) Existence of A Threshold for Hydroxyl Radical Generation Independent of Hypoxia in Rat Striatum during Carbon Monoxide Poisoning. Archives of Toxicology, 85, 1091-1099. [Google Scholar] [CrossRef] [PubMed]
[19] Childs, J., Fischbach, A., Smirnov, A., et al. (2023) Extracorporeal Membrane Oxygenators with Light-Diffusing Fibers for Treatment of Carbon Monoxide Poisoning: Experiments, Mathematical Modeling, and Performance Assessment with Unit Cells. Lasers in Surgery and Medicine, 6, 590-600. [Google Scholar] [CrossRef] [PubMed]
[20] Geocadin, R.G., Koenig, M.A., Jia, X., et al. (2008) Management of Brain Injury after Resuscitation from Cardiac Arrest. Neurologic Clinics, 2, 487-506. [Google Scholar] [CrossRef] [PubMed]
[21] Moloney, M.G. (2002) Excitatory Amino Acids. Natural Product Reports, 5, 597-616. [Google Scholar] [CrossRef] [PubMed]
[22] Rose, J.J., Wang, L., Xu, Q., et al. (2017) Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy. American Journal of Respiratory and Critical Care Medicine, 195, 596-606. [Google Scholar] [CrossRef] 
[23] Jia, Y., Chen, Y., Geng, K., et al. (2020) Glutamate Chemical Exchange Saturation Transfer (GluCEST) Magnetic Resonance Imaging in Pre-Clinical and Clinical Applications for Encephalitis. Frontiers in Neuroscience, 14, Article 750. [Google Scholar] [CrossRef] [PubMed]
[24] Peng, M., Ling, X., Song, R., et al. (2019) Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine. Frontiers in Neurology, 10, Article 1041. [Google Scholar] [CrossRef] [PubMed]
[25] Peng, H. and Tian, W.S. (2019) Research on the Pathogenesis of Late-Onset Encephalopathy with Carbon Monoxide Poisoning. Inner Mongolia Journal of Medicine, 51, 1043-1046.
[26] Kudo, N., Yamamori, H., Ishima, T., et al. (2020) Plasma Levels of Matrix Metalloproteinase-9 (MMP-9) Are Associated with Cognitive Performance in Patients with Schizophrenia. Neuropsychopharmacology Reports, 2, 150-156. [Google Scholar] [CrossRef] [PubMed]
[27] Wang, R., Li, K., Wang, Z., et al. (2024) Changes of Nuclear Factor κ-B Pathway Activity in Hippocampus after Acute Carbon Monoxide Poisoning and Its Role in Nerve Cell Injury. Molecular Neurobiology. [Google Scholar] [CrossRef] [PubMed]
[28] Ignatowski, T.A., Spengler, R.N., Dhandapani, K.M., et al. (2014) Perispinal Etanercept for Post-Stroke Neurological and Cognitive Dysfunction: Scientific Rationale and Current Evidence. CNS Drugs, 8, 679-697. [Google Scholar] [CrossRef] [PubMed]
[29] Rubin, L., Stabler, C.T., Schumacher-Klinger, A., et al. (2021)Neurotrophic Factors and Their Receptors in Lung Development and Implications in Lung Diseases. Cytokine & Growth Factor Reviews, 59, 84-94. [Google Scholar] [CrossRef] [PubMed]
[30] Li, Z.K., Li, C.H., Yue, A.C., et al. (2022) Therapeutic Effect and Molecular Mechanism of Salvia Miltiorrhiza on Rats with Acute Brain Injury after Carbon Monoxide Poisoning Based on the Strategy of Internet Pharmacology. Environmental Toxicology, 3, 413-434. [Google Scholar] [CrossRef] [PubMed]
[31] Gao, L.L., Wang, Z.H., Mu, Y.H., et al. (2024) Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling. Pathobiology, 3, 135-145. [Google Scholar] [CrossRef] [PubMed]
[32] Ciszowski, K., Gomółka, E., Gawlikowski, T., et al. (2016) Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) Blood Levels in Patients with Acute Carbon Monoxide Poisoning—A Preliminary Observations. Przeglad Lekarski, 8, 552-559.
[33] Andero, R., Choi, D.C. and Ressler, K.J. (2014) BDNF-TrkB Receptor Regulation of Distributed Adult Neural Plasticity, Memory Formation, and Psychiatric Disorders. Progress in Molecular Biology and Translational Science, 122, 169-192. [Google Scholar] [CrossRef] 
[34] Yanagiha, K., Ishii, K. and Tamaoka, A. (2017) Acetylcholinesterase Inhibitor Treatment Alleviated Cognitive Impairment Caused by Delayed Encephalopathy Due to Carbon Monoxide Poisoning: Two Case Reports and a Review of the Literature. Medicine, 96, e6125. [Google Scholar] [CrossRef] 
[35] Liu, W.C., Yang, S.N., Wu, C.W., et al. (2016) Hyperbaric Oxygen Therapy Alleviates Carbon Monoxide Poisoning-Induced Delayed Memory Impairment by Preserving Brain-Derived Neurotrophic Factor-Dependent Hippocampal Neurogenesis. ical Care Medicine, 44, e25-e39. [Google Scholar] [CrossRef] 
[36] Zhang, L., Sun, Q., Xin, Q., et al. (2021) Hyperbaric Oxygen Therapy Mobilized Circulating Stem Cells and Improved Delayed Encephalopathy after Acute Carbon Monoxide Poisoning with Up-Regulation of Brain-Derived Neurotrophic Factor. The American Journal of Emergency Medicine, 42, 95-100. [Google Scholar] [CrossRef] [PubMed]
[37] 冯新春, 高磊. 大剂量甲泼尼龙联合高压氧治疗急性一氧化碳中毒迟发性脑病患者的疗效分析[J]. 山西医药杂志, 2021, 50(7): 1154-1157.
[38] Song, H., Yue, A., Zhou, X., et al. (2024) Evidence of Clinical Efficacy and Pharmacological Mechanism of N-Butylphthalide in the Treatment of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. Frontiers in Neurology, 14, Article 1119871. [Google Scholar] [CrossRef] [PubMed]
[39] Zhang, J., Guo, Y., Li, W., et al. (2020) The Efficacy of N-Butylphthalide and Dexamethasone Combined with Hyperbaric Oxygen on Delayed Encephalopathy after Acute Carbon Monoxide Poisoning. Drug Design, Development and Therapy, 14, 1333-1339. [Google Scholar] [CrossRef] 

为你推荐