中医药调控JAK/STAT信号通路介导溃疡性结肠炎的研究进展

Progress of Chinese Medicine in Regulating JAK/STAT Signaling Pathway Mediating Ulcerative Colitis

摘要: 溃疡性结肠炎是一种难治性慢性非特异性炎症性肠病，严重影响患者身心健康及生活质量。中医治疗溃疡性结肠炎具有复发率低、不良反应少的优势，方药、穴位敷贴、艾灸等都有较好的临床疗效。本文将从分子生物学的角度阐述中医药对溃疡性结肠炎的作用机制。JAK/STAT信号通路与炎症反应具有密切关系，激活后引起肠黏膜屏障损伤。近年来应用中医药调控JAK/STAT信号通路治疗溃疡性结肠炎成为研究热点。本文就中医药通过调控JAK/STAT信号通路治疗溃疡性结肠炎做一综述，为有效用药及药物研发提供依据。

Abstract: Ulcerative colitis is a refractory chronic non-specific inflammatory bowel disease, which seriously affects the physical and mental health and quality of life of patients. Traditional Chinese medicine (TCM) treatment of ulcerative colitis has the advantages of low recurrence rate and fewer adverse reactions, and prescription medicines, acupoints, moxibustion, etc. have better clinical efficacy. In this paper, we will elaborate the mechanism of TCM on ulcerative colitis from the perspective of molecular biology. JAK/STAT signaling pathway has a close relationship with inflammatory response, and its activation causes intestinal mucosal barrier damage. The activation of JAK/STAT signaling pathway is closely related to the inflammatory response, causing damage to the intestinal mucosal barrier. In this paper, we review the use of traditional Chinese medicine in the treatment of ulcerative colitis by regulating the JAK/STAT signaling pathway, which will provide a basis for the effective use of medication and drug development.