息肉样脉络膜血管病变病因相关研究进展
Research Progress on the Etiology of Polypoid Choroidal Vascular Disease
DOI: 10.12677/acm.2024.1451560, PDF,   
作者: 祖丽皮耶·艾力*:新疆医科大学第四临床医学院,新疆 乌鲁木齐;赵 勇#:新疆医科大学附属中医院眼科,新疆 乌鲁木齐
关键词: 息肉样脉络膜血管病变病因细胞因子Polypoid Choroidal Vascular Disease Etiology Cytokines
摘要: 息肉样脉络膜血管病变是一种脉络膜视网膜疾病,伴有血管动脉瘤息肉样病变,伴有或不伴有相关分支血管网络。主诉有视物模糊、视力下降、中心暗点等。该病相关研究少,至今未明确病因,近来更多的研究者发现多种细胞因子水平的异常与息肉状脉络膜血管病的风险有关联,本研究旨在深入探寻房水及玻璃体液细胞因子水平与PCV发生的相关性。
Abstract: Polypoid chorioretinopathy is a chorioretinal disease accompanied by vascular aneurysms and polypoid lesions, with or without related branching vascular networks. The main complaints include blurred vision, decreased vision, and central dark spots. There is limited research on this disease and the etiology has not been determined yet. Recently, more researchers have found that abnormal levels of various cytokines are associated with the risk of polypoid choroidal vasculopathy. This study aims to further explore the correlation between cytokine levels in aqueous humor and vitreous humor and the occurrence of PCV.
文章引用:祖丽皮耶·艾力, 赵勇. 息肉样脉络膜血管病变病因相关研究进展[J]. 临床医学进展, 2024, 14(5): 1352-1359. https://doi.org/10.12677/acm.2024.1451560

参考文献

[1] Yannuzzi, L.A., Sorenson, J., Spaide, R.F. and Lipson, B. (1990) Idiopathic Polypoidal Choroidal Vasculopathy (IPCV). Retina, 10, 1-8. [Google Scholar] [CrossRef
[2] Spaide, R.F., Yannuzzi, L.A., Slakter, J.S., Sorenson, J. and Orlach, D.A. (1995) Indocyanine Green Videoangiography of Idiopathic Polypoidal Choroidal Vasculopathy. Retina, 15, 100-110. [Google Scholar] [CrossRef] [PubMed]
[3] Cheung, C.M.G., Lai, T.Y.Y., Teo, K., et al. (2021) Polypoidal Choroidal Vasculopathy. Ophthalmology, 128, 443-452. [Google Scholar] [CrossRef] [PubMed]
[4] 严桢桢, 许祎, 刘志南. 雷珠单抗与康柏西普联合光动力疗法治疗息肉样脉络膜血管病变的疗效比较[J]. 国际眼科杂志, 2022, 22(1): 123-126.
[5] 杨景元, 王尔茜, 陈有信. 光动力疗法与玻璃体腔注射抗血管内皮生长因子制剂治疗息肉样脉络膜血管病变的Meta分析[J]. 中华眼底病杂志, 2016, 32(1): 73-78.
[6] Sharma, A., Parachuri, N., Kumar, N., et al. (2022) Brolucizumab in Polypoidal Choroidal Vasculopathy. Expert Opinion on Biological Therapy, 22, 809-812. [Google Scholar] [CrossRef] [PubMed]
[7] Cheung, C.M., Laude, A., Yeo, I., et al. (2017) Systemic, Ocular and Genetic Risk Factors for Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans. Scientific Reports, 7, Article No. 41386. [Google Scholar] [CrossRef] [PubMed]
[8] 刘子扬, 陈有信. 息肉状脉络膜血管病变的危险因素分析[J]. 眼科新进展, 2018, 38(6): 538-541.
[9] Rishi, P., Rishi, E., Mathur, G. and Raval, V. (2013). Ocular Perfusion Pressure and Choroidal Thickness in Eyes with Polypoidal Choroidal Vasculopathy, Wet-Age-Related Macular Degeneration, and Normals. Eye, 27, 1038-1043.[CrossRef] [PubMed]
[10] Koizumi, H., Yamagishi, T., Yamazaki, T. and Kinoshita, S. (2013) Relationship between Clinical Characteristics of Polypoidal Choroidal Vasculopathy and Choroidal Vascular Hyperpermeability. American Journal of Ophthalmology, 155, 305-313.e1.
[11] Li, Y., You, Q.S., Wei, W.B., et al. (2014) Polypoidal Choroidal Vasculopathy in Adult Chinese: The Beijing Eye Study. Ophthalmology, 121, 2290-2291.
[12] Chaikitmongkol, V., Cheung, C.M.G., Koizumi, H., et al. (2020) Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment. Asia-Pacific Journal of Ophthalmology, 9, 260-268. [Google Scholar] [CrossRef
[13] Nita, M. and Grzybowski, A. (2017) Smoking and Eye Pathologies. A Systemic Review. Part II. Retina Diseases, Uveitis, Optic Neuropathies, Thyroid-Associated Orbitopathy. Current Pharmaceutical Design, 23, 639-654. [Google Scholar] [CrossRef] [PubMed]
[14] Cackett, P., Yeo, I., Cheung, C.M.G., Cheung, C, Vithana, E.N., et al. (2011) Relationship of Smoking and Cardiovascular Risk Factors with Polypoidal Choroidal Vasculopathy and Age-Related Macular Degeneration in Chinese Persons. Ophthalmology, 118, 846-852. [Google Scholar] [CrossRef] [PubMed]
[15] 刘冉, 李加青, 曾婧, 等. 渗出型老年性黄斑变性与息肉样脉络膜血管病变患者年龄、性别及发病眼别的比较[J]. 中华眼底病杂志, 2012(5): 445-448.
[16] Hou, J., Tao, Y., Li, X.X., et al. (2011) Clinical Characteristics of Polypoidal Choroidal Vasculopathy in Chinese Patients. Graefes Archive for Clinical and Experimental Ophthalmology, 249, 975-979. [Google Scholar] [CrossRef] [PubMed]
[17] Woo, S.J., Ahn, J., Morrison, M.A., et al. (2015) Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. PLOS ONE, 10, e0132771. [Google Scholar] [CrossRef] [PubMed]
[18] 胡立影, 李志清, 高飞, 等. 不同生活方式与息肉状脉络膜血管病变发病的关系[J]. 眼科新进展, 2020, 40(6): 566-568.
[19] Kumar, M., Moptom, S.E., Sen, P., et al. (2020) Prevalence of Polypoidal Choroidal Vasculopathy in Indian Population: Risk Factors, Clinical and Imaging Characteristics. PLOS ONE, 15, e0231901. [Google Scholar] [CrossRef] [PubMed]
[20] Sakurada, Y., Yoneyama, S., Imasawa, M., et al. (2013) Systemic Risk Factors Associated with Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. Retina, 33, 841-845. [Google Scholar] [CrossRef
[21] Lip, P.L., Hope-Ross, M.W. and Gibson, J.M. (2000) Idiopathic Polypoidal Choroidal Vasculopathy: A Disease with Diverse Clinical Spectrum and Systemic Associations. Eye, 14, 695-700. [Google Scholar] [CrossRef] [PubMed]
[22] Grover, D.P. (2010) Obstructive Sleep Apnea and Ocular Disorders. Current Opinion in Ophthalmology, 21, 454-458. [Google Scholar] [CrossRef
[23] 朱哲, 张晨晨, 肖骏. HtrA1丝氨酸蛋白酶在息肉状脉络膜血管病变发病机制中作用的研究进展[J]. 中华眼视光学与视觉科学杂志, 2020, 22(10): 796-800.
[24] Chen, L.J. (2020) Genetic Association of Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Asia-Pacific Journal of Ophthalmology, 9, 104-109. [Google Scholar] [CrossRef
[25] Ma, L., Li, Z., Liu, K., et al. (2015) Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-Analysis. Ophthalmology, 122, 1854-1865.
[26] 徐青, 乔磊, 宫朝举, 等. 影响息肉状脉络膜血管病变抗VEGF治疗后OCTA指标变化的房水靶细胞因子分析[J]. 中华实验眼科杂志, 2021, 39(7): 632-639.
[27] McColl, B.K., Stacker, S.A. and Achen, M.G. (2004) Molecular Regulation of the VEGF Family—Inducers of Angiogenesis and Lymphangiogenesis. APMIS, 112, 463-480. [Google Scholar] [CrossRef] [PubMed]
[28] Adams, R.H. and Alitalo, K. (2007) Molecular Regulation of Angiogenesis and Lymphangiogenesis. Nature Reviews Molecular Cell Biology, 8, 464-478. [Google Scholar] [CrossRef] [PubMed]
[29] Kuroki, M., Voest, E.E., Amano, S., et al. (1996) Reactive Oxygen Intermediates Increase Vascular Endothelial Growth Factor Expression in Vitro and in Vivo. Journal of Clinical Investigation, 98, 1667-1675. [Google Scholar] [CrossRef
[30] Guyot, M. and Pagès, G. (2015) VEGF Splicing and the Role of VEGF Splice Variants: From Physiological-Pathological Conditions to Specific Pre-MRNA Splicing. In: Fiedler, L., Ed., VEGF Signaling, Humana Press, New York, 3-23. [Google Scholar] [CrossRef] [PubMed]
[31] Hu, J., Leng, X., Hu, Y., et al. (2016) The Features of Inflammation Factors Concentrations in Aqueous Humor of Polypoidal Choroidal Vasculopathy. PLOS ONE, 11, e0147346. [Google Scholar] [CrossRef] [PubMed]
[32] Sun, T., Bai, J., Wang, M., et al. (2022) Cytokine Profiling in Patients with Polypoidal Choroidal Vasculopathy before and after Intravitreal Injection of Ranibizumab. American Journal of Translational Research, 14, 7147-7155.
[33] Agrawal, R., Balne, P.K., Wei, X., et al. (2019) Cytokine Profiling in Patients with Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Investigative Ophthalmology & Visual Science, 60, 376-382. [Google Scholar] [CrossRef] [PubMed]
[34] Lee, W.K., Iida, T., Ogura, Y., et al. (2018) Efficacy and Safety of Intravitreal Aflibercept for Polypoidal Choroidal Vasculopathy in the PLANET Study: A Randomized Clinical Trial. JAMA Ophthalmology, 136, 786-793. [Google Scholar] [CrossRef] [PubMed]
[35] Li, X., Zhu, Q., Egger, A., et al. (2021) Two Different Treatment Regimens of Ranibizumab 0.5 Mg for Neovascular Age-Related Macular Degeneration with or without Polypoidal Choroidal Vasculopathy in Chinese Patients: Results from the Phase IV, Randomized, DRAGON Study. Acta Ophthalmologica, 99, e336-e345. [Google Scholar] [CrossRef] [PubMed]
[36] Lin, J., Kakkar, V. and Lu, X. (2014) Impact of MCP-1 in Atherosclerosis. Current Pharmaceutical Design, 20, 4580-4588. [Google Scholar] [CrossRef] [PubMed]
[37] Kato, Y., Oguchi, Y., Omori, T., et al. (2020) Complement Activation Products and Cytokines in Pachychoroid Neovasculopathy and Neovascular Age-Related Macular Degeneration. Investigative Ophthalmology & Visual Science, 61, 39. [Google Scholar] [CrossRef] [PubMed]
[38] Sørensen, J., Subhi, Y., Molbech, C.R., et al. (2020) Plasma Levels of Inflammatory Chemokines in Patients with Polypoidal Choroidal Vasculopathy. Acta Ophthalmologica, 98, 384-389. [Google Scholar] [CrossRef] [PubMed]
[39] Yang, K.B., Sun, X.Y., Sun, L.P., et al. (2021) Aqueous Humor Cytokine Levels and Rebound Macular Edema after Conbercept Treatment in Patients with Central Retinal Vein Occlusion. Retina, 41, 834-843. [Google Scholar] [CrossRef
[40] Balne, P.K., Agrawal, R., Au, V.B., et al. (2018) Dataset of Plasma and Aqueous Humor Cytokine Profiles in Patients with Exudative Age Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Data in Brief, 19, 1570-1573. [Google Scholar] [CrossRef] [PubMed]
[41] Mimura, T., Funatsu, H., Noma, H., et al. (2019) Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration. Ophthalmologica, 241, 81-89. [Google Scholar] [CrossRef] [PubMed]
[42] Sakurada, Y., Nakamura, Y., Yoneyama, S., et al. (2015) Aqueous Humor Cytokine Levels in Patients with Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. Ophthalmic Research, 53, 2-7. [Google Scholar] [CrossRef] [PubMed]
[43] 何婷, 黄跃生, 白晓东. 色素上皮衍生因子的研究进展[J]. 医学研究生学报, 2018, 31(4): 419-424.
[44] Tombran-Tink, J. and Johnson, L.V. (1989) Neuronal Differentiation of Retinoblastoma Cells Induced by Medium Conditioned by Human RPE Cells. Investigative Ophthalmology & Visual Science, 30, 1700-1707.
[45] 张英辉, 李建军, 杨洪帅, 等. 渗出性老年黄斑变性患者玻璃体腔注射康柏西普前后房水中血管内皮生长因子、色素上皮细胞衍生因子浓度的变化[J]. 药物评价研究, 2018, 41(9): 1703-1707.
[46] 卜倩, 阿依努∙努拉厚. 息肉样脉络膜视网膜病变患者血清细胞因子检测及危险因素分析[J]. 国际眼科杂志, 2020, 20(2): 354-357.
[47] Schoenberger, S.D., Kim, S.J., Sheng, J., et al. (2012) Increased Prostaglandin E2 (PGE2) Levels in Proliferative Diabetic Retinopathy, and Correlation with VEGF and Inflammatory Cytokines. Investigative Ophthalmology & Visual Science, 53, 5906-5911. [Google Scholar] [CrossRef] [PubMed]
[48] Mo, J.S., Matsukawa, A., Ohkawara, S., et al. (2000) CXC Chemokine GRO Is Essential for Neutrophil Infiltration in LPS-Induced Uveitis in Rabbits. Experimental Eye Research, 70, 221-226. [Google Scholar] [CrossRef] [PubMed]
[49] Sakamoto, S., Takahashi, H., Tan, X., et al. (2018) Changes in Multiple Cytokine Concentrations in the Aqueous Humour of Neovascular Age-Related Macular Degeneration after 2 Months of Ranibizumab Therapy. British Journal of Ophthalmology, 102, 448-454. [Google Scholar] [CrossRef] [PubMed]
[50] Liu, F., Ding, X., Yang, Y., et al. (2016) Aqueous Humor Cytokine Profiling in Patients with Wet AMD. Molecular Vision, 22, 352-361.
[51] Zlotnik, A. and Yoshie, O. (2000) Chemokines: A New Classification System and Their Role in Immunity. Immunity, 12, 121-127. [Google Scholar] [CrossRef
[52] Maghazachi, A.A. (2010) Role of Chemokines in the Biology of Natural Killer Cells. Current Topics in Microbiology and Immunology, 341, 37-58. [Google Scholar] [CrossRef] [PubMed]
[53] Zhou, H., Zhao, X., Yuan, M., et al. (2020) Comparison of Cytokine Levels in the Aqueous Humor of Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration Patients. BMC Ophthalmology, 20, Article No. 15. [Google Scholar] [CrossRef] [PubMed]
[54] Zhou, H., Zhao, X. and Chen, Y. (2022) Plasma Cytokine Profiles in Patients with Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration. Asia-Pacific Journal of Ophthalmology, 11, 536-542. [Google Scholar] [CrossRef
[55] 杜月, 杜红艳. 房水中细胞因子和血清C反应蛋白在息肉状脉络膜血管病变中的表达[J]. 内蒙古医学杂志, 2022, 54(5): 562-565.