针药结合治疗更年期抑郁症的Meta分析

Meta-Analysis of Acupuncture and Medicine in the Treatment of Menopausal Depression

摘要: 目的：系统评价针药结合治疗更年期抑郁症的临床疗效。方法：通过计算机检索中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)、PubMed、Web of Science、The Cochrane Library、Embase数据库自建库至2024年1月的有关针药结合治疗更年期抑郁症的临床文献，经过筛选与质量评估后，使用RevMan 5.3进行Meta分析。结果：共纳入15篇文献，经过Meta分析显示结果表明，针药结合治疗同单纯用中药治疗更年期抑郁症相比，差异具有统计学意义，其总有效率OR = 4.71，95%CI (3.17, 7.01)；针药结合治疗同单纯用中药治疗更年期抑郁症相比，其HAMD评分MD = −3.29，95%CI (−4.70, −1.88)；针药结合治疗同单纯用中药治疗更年期抑郁症相比，其Kupperman评分MD = −3.32，95%CI (−5.63, −1.00)。结论：针药结合治疗更年期抑郁症的临床效果优于单纯运用中药治疗更年期抑郁症。

Abstract: Objective: To systematically evaluate the clinical efficacy of acupuncture and medicine in the treatment of menopausal depression. Methods: The clinical literature on the treatment of climactic depression by the combination of acupuncture and medicine was searched by computer from CNKI, WANFANG DATA, VIP Chinese Science and Technology periodical database, PubMed, Web of Science, The Cochrane Library, Embase database self-established until January 2024. After screening and quality assessment, meta-analysis was performed using RevMan 5.3. Results: A total of 15 literatures were included, and meta-analysis showed that there was a statistically significant difference between acupuncture and medicine combination treatment and simple Chinese medicine treatment of menopausal depression. The total effective rate was OR = 4.71, 95%CI (3.17, 7.01); Compared with the treatment of menopausal depression with traditional Chinese medicine alone, the HAMD score MD = −3.29, 95%CI (−4.70, −1.88); the combination of acupuncture and medicine is similar to the treatment of menopausal depression with traditional Chinese medicine alone. In comparison, its Kupperman score MD = −3.32, 95%CI (−5.63, −1.00). Conclusion: The clinical effect of acupuncture and medicine in the treatment of menopausal depression is better than that of using traditional Chinese medicine alone in the treatment of menopausal depression.