EIF4A3在高级别浆液性卵巢癌中的表达及临床意义
Expression of EIF4A3 in High-Grade Serous Ovarian Cancer and Its Clinical Significance
DOI: 10.12677/acm.2024.1451581, PDF,    科研立项经费支持
作者: 戴 旭：青岛大学医学部，山东 青岛；中国人民解放军联勤保障部队第970医院妇产科，山东 威海；田 甜, 王灵芝*：青岛大学附属医院妇科，山东 青岛；初慧君, 周洋帆：青岛大学医学部，山东 青岛；陈潭琇：江西省肿瘤医院科研科，江西 南昌
关键词: EIF4A3；高级别浆液性卵巢癌；免疫组化；生物信息学分析；EIF4A3； High-Grade Serous Ovarian Cancer； Immunohistochemistry； Bioinformatic Analysis
摘要: 目的：探索EIF4A3的表达与高级别浆液性卵巢癌患者临床病理特征和预后的关系，明确其在高级别浆液性卵巢癌发生发展过程中的作用。方法：采用免疫组织化学方法检测EIF4A3在高级别浆液性卵巢癌组织、交界性卵巢肿瘤组织以及正常输卵管组织中的表达情况，分析其表达对高级别浆液性卵巢癌临床病理特征及预后的影响。通过TIMER数据库分析EIF4A3在泛癌中的表达水平。通过Sangerbox工具分析EIF4A3表达在泛癌中的预后情况。通过cBioportal网站分析EIF4A3在卵巢癌组织中基因突变的情况。通过GeneMANIA网站构建与EIF4A3共表达基因网络图，其中与EIF4A3最有关系的5个基因分别为ETF1、CENPX、DDX21、DDX31和JMJD6。结果：EIF4A3在高级别浆液性卵巢癌组织中的表达高于交界性卵巢肿瘤和正常输卵管组织(P < 0.05)；EIF4A3表达水平与临床病理分期有关(P < 0.05)；EIF4A3在高级别浆液性卵巢癌中高表达患者总生存率低，与不良预后有关(P < 0.05)。结论：EIF4A3在高级别浆液性卵巢癌中高表达，与临床病理特征及不良预后有关，EIF4A3可能参与卵巢癌的发生和发展。
Abstract: Objective: To explore the expression of EIF4A3 in high-grade serous ovarian cancer and its relationship with the clinicopathological characteristics and prognosis of the patients, and to clarify its role in the development of high-grade serous ovarian cancer. Methods: The expression of EIF4A3 in high-grade serous ovarian cancer tissues, borderline ovarian tumor tissues, and normal fallopian tube tissues was detected by immunohistochemistry. The effects of its expression on various clinical pathological features and prognosis of high-grade serous ovarian cancer are analyzed. The expression level of EIF4A3 in pan-cancer was analyzed by TIMER database. Sangerbox tools were used to analyze the prognosis of EIF4A3 expression in pan-cancer. EIF4A3 gene mutations in ovarian cancer tissues are analyzed by using the cBioportal website. GeneMANIA website was used to construct a network map of genes co-expressed with EIF4A3, in which the five genes most related to EIF4A3 were ETF1, CENPX, DDX21, DDX31 and JMJD6. Results: The expression of EIF4A3 in high-grade serous ovarian cancer tissues was higher than that in borderline ovarian tumors and normal fallopian tube tissues (P < 0.05). The expression level of EIF4A3 was associated with the clinicopathologic stage (P < 0.05). The low overall survival rate of patients with high EIF4A3 expression in high-grade serous ovarian cancer was associated with poor prognosis (P < 0.05). Conclusion: EIF4A3 was highly expressed in high-grade serous ovarian cancer, which was associated with clinicopathological characteristics and poor prognosis. EIF4A3 is involved in the occurrence and development of ovarian cancer.
文章引用：戴旭, 田甜, 初慧君, 周洋帆, 陈潭琇, 王灵芝. EIF4A3在高级别浆液性卵巢癌中的表达及临床意义[J]. 临床医学进展, 2024, 14(5): 1515-1525. https://doi.org/10.12677/acm.2024.1451581

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