卵巢不敏感综合征(ROS)的综合诊断：附1例ROS合并高雄激素血症报道

Comprehensive Diagnosis of Ovarian Insensitivity Syndrome (ROS): A Case Report of ROS with Hyperandrogenemia

摘要: 卵巢不敏感综合征(ROS)是由于卵巢组织对卵泡刺激素(FSH)和(或)黄体生成素(LH)不敏感引起的高促性腺激素性闭经或月经稀发、不孕的一种女性生殖内分泌疾病。临床罕见，症状缺乏特异性，易和卵巢早衰、多囊卵巢综合征等相混淆。本文通过1例25岁女性患者的诊断过程探讨ROS的综合诊断措施。我们认为对于高促性腺激素性月经异常的年轻女性，尤其FSH升高为主者，在排除卵巢器质性病变的基础上，如抗苗勒管激素(AMH)正常，就应考虑ROS，FSH及LH受体基因测序有助于诊断确立。

Abstract: Ovarian insensitivity syndrome (ROS) is a female reproductive endocrine disease caused by high gonadotropin-induced amenorrhea, infrequent menstruation, and infertility due to the insensitivity of ovarian tissue to follicle stimulating hormone (FSH) and/or luteinizing hormone (LH). Clinically rare, the symptoms lack specificity and are easily confused with premature ovarian failure, polycystic ovary syndrome, etc. This article explores the comprehensive diagnostic measures for ROS through the diagnostic process of a 25-year-old female patient. We believe that for young women with high gonadotropin-induced menstrual abnormalities, especially those with elevated FSH, on the basis of excluding ovarian organic lesions, such as normal anti Mullerian hormone (AMH), ROS, FSH, and LH receptor gene sequencing should be considered to help establish diagnosis.