关于膝骨关节炎病因的中西医研究进展

Progress in Traditional Chinese and Western Medicine Research on the Etiology of Knee Osteoarthritis

摘要: 膝骨关节炎(KOA)是最常见的慢性疾病之一，好发于老年群体，该疾病以疼痛、功能丧失为主要特点，严重影响患者生活质量。目前学术界对该疾病的认识已经具备一定高度，但无论从临床、学术角度而言，攻克KOA仍有很长一段距离。中医古籍从正邪出发，阐述正邪之间关系是引起疾病的重点；而在西医上解剖、性别或者说激素水平、衰老、创伤或者术后、社会因素如工作、受教育程度等都是KOA的致病因素。另外，近年来如软骨硬化、肠道菌群、软骨细胞的衰老等理论提出，又进一步提高了学术界对KOA的认知水平。总的来说，KOA病因的中西医研究进展的必要性在于：尽可能总结现有学术界对该疾病的认识，在现有的基础上更好、更深入地攻克KOA。

Abstract: Knee osteoarthritis (KOA) is one of the most common chronic diseases, which occurs in the elderly. The disease is mainly characterized by pain and loss of function, which seriously affects the quality of life of patients. At present, the academic community has a certain degree of understanding of this disease, but there is still a long way to conquer KOA from both clinical and academic perspectives. The ancient books of TCM had expounded the relationship between Healthy Qi and Pathogenic Qi which is the key to causing diseases. In western medicine, anatomy, gender and hormone level, aging, trauma, postoperative, social factors such as work and education are the pathogenic factors of KOA. In addition, in recent years, theories such as cartilage sclerosis, intestinal flora and aging of chondrocytes have been put forward, which has further improved the cognitive level of KOA in the academic circle. In general, the necessity of the research progress of traditional Chinese and western medicine on the cause of KOA is to summarize the existing academic understanding of the disease as much as possible, and to better and further conquer KOA on the existing basis.