中国汉族人群LIPA rs1051338位点多态性与非酒精性脂肪性肝病发病风险的相关性分析

Correlation Analysis of LIPA rs1051338 and Risk of Non-Alcoholic Fatty Liver Disease in Chinese Han Population

摘要: 目的：非酒精性脂肪性肝病(Non-alcoholic fatty liver disease, NAFLD)是最重要的慢性肝脏疾病，其发生发展受遗传等因素影响。国外研究报道LIPA rs1051338是影响NAFLD发生的潜在位点，但在中国人群中尚未有报道。本研究拟探讨LIPA基因rs1051338位点多态性与中国北方汉族人群NAFLD发生风险的相关性，并揭示其对于血脂等指标的影响。方法：本研究采用病例对照研究方法，对比NAFLD组与健康对照组间LIPA rs1051338位点的等位基因及基因型分布之间的差异，并通过logistic回归模型分析LIPA rs1051338位点基因多态性与NAFLD易感性的关系。对比不同基因型携带者之间临床资料间的差异揭示该位点突变对于各种指标的影响。结果：LIPA rs1051338位点的等位基因和基因型在NAFLD组和健康对照组间的分布均无显著差异(P= 0.195和0.434)。二元logistic回归模型分析LIPA rs1051338位点基因多态性与NAFLD发生风险无显著相关。在全部受试者和NAFLD患者中，CA/CC基因型携带者的SBP、DBP和LDL水平较AA基因型携带者明显升高(P均<0.05)。结论：在我国北方汉族人群中，LIPA基因rs1051338位点多态性与NAFLD发生风险不具有相关性。在全部受试者和NAFLD患者中，CA/CC基因型携带者的SBP、DBP和LDL水平较AA基因型携带者明显升高。

Abstract: Objective: Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver diseases, and its occurrence and development are influenced by genetic factors. Foreign studies showed that LIPA rs1051338 was associated with the risk of NAFLD, but no related studies were reported in China. This study aims to explore the correlation between LIPA rs1051338 polymorphism and the risk of NAFLD in northern Han population China, and to reveal its influence on lipid and other indicators. Methods: A case-control study was conducted to compare the distribution of alleles and genotypes of LIPA rs1051338 between NAFLD group and healthy control group, and the relationship between LIPA rs1051338 polymorphism and the risk of NAFLD was analyzed by logistic regression model. Comparison of clinical data between carriers of different genotypes revealed the effect of LIPA rs1051338 polymorphism on various indicators. Results: There was no significant difference in the distribution of alleles and genotypes of LIPA rs1051338 between NAFLD group and healthy control group (P = 0.195 and 0.434). There was no significant correlation between LIPA rs1051338 polymorphism and the risk of NAFLD by binary logistic regression analysis. In all subjects and NAFLD patients, the levels of SBP, DBP and LDL in CA/CC genotype carriers were significantly higher than those in AA genotype carriers (all P < 0.05). Conclusion: There is no correlation between LIPA rs1051338 polymorphism and the risk of NAFLD in northern Han population, China. In all subjects and NAFLD patients, the levels of SBP, DBP and LDL in CA/CC genotype carriers were significantly higher than those in AA genotype carriers.