川崎病患儿IVIG抵抗影响因素分析

Analysis of Influencing Factors on IVIG Resistance in Children with Kawasaki Disease

摘要: 目的：探讨儿童川崎病患儿静脉注射丙种球蛋白(IVIG)抵抗的影响因素。方法：回顾性分析2015年1月至2023年10月西北妇女儿童医院收治的652例川崎病患儿中49例的临床资料。采用二元Logistic回归对影响IVIG抵抗的多种因素进行分析。采用stata15.0软件对回归模型进行ROC曲线分析，计算其最佳截断值及曲线下面积(AUC)。结果：川崎病抵抗与IVIG抵抗与发热天数，中性粒细胞(Neutrophils, N)比例，淋巴细胞(lymphocyte, L)比例，血红蛋白(hemoglobin, HB)，血清钠，脓尿，动脉瘤及使用激素等因素有关(P < 0.05)。结论：川崎病抵抗与多种因素有关，包括发热天数，N比例，L比例，HB，血清钠，脓尿，动脉瘤及使用激素等8个因素有关。

Abstract: Objective: To Explore the influencing factors of intravenous immunoglobulin resistance in children with Kawasaki disease. Methods: Retrospective analysis of clinical data of 49 out of 652 children with Kawasaki disease admitted to Northwest Women’s and Children’s Hospital from January 2015 to October 2023. The application uses binary Logistic regression to analyze multiple factors that affect IVIG resistance. Perform ROC curve analysis on the regression model using stata15.0 software, and calculate its optimal cutoff value and area under the curve (AUC). Result: Kawasaki disease resistance and IVIG resistance are related to factors such as fever duration, Neutrophil (N) ratio, lymphocyte (L) ratio, hemoglobin (HB), serum sodium, pyuria, arterial aneurysm, and hormone use (P < 0.05). Conclusion: Kawasaki disease resistance is related to various factors, including fever days, N ratio, L ratio, HB, serum sodium, pyuria, aneurysm, and use of the hormone.