1例NTRK重排的巨大纵膈梭形细胞瘤病例报告

One Case Report of Giant Mediastinal Spindle Cell Tumor with NTRK Rearrangement

摘要: 神经原肌球蛋白相关激酶(Neurotropomyosin-related kinase, NTRK)重排的梭形细胞肿瘤是世界卫生组织第五版软组织和骨肉瘤分类中的一类新肿瘤。迄今为止，很少有报告纵隔发生NTRK重排的梭形细胞瘤病例。因此，我们收集了一例巨大的(27 × 21 × 10 cm)纵膈NTRK重排的梭形细胞肿瘤病例。手术采取了保留肋骨的三切口开胸术。术后病理诊断为梭形细胞瘤。免疫组化结果显示，肿瘤组织中平滑肌肌动蛋白、S100、CD34、NTRK均呈阳性表达。通过讨论该病的病理类型、诊断和治疗，为其临床诊疗提供更多参考。

Abstract: Neurotropomyosin-related kinase (NTRK) rearranged spindle cell neoplasm (SCN) represents a new group of tumors included in the fifth edition of the World Health Organization (WHO) classification of soft tissue and bone sarcomas. To date, few cases of NTRK-rearranged SCN in the mediastinum in the mediastinum have been reported. Herein we present a case of a giant (27 × 21 × 10 cm) NTRK rearranged SCN in the right thoracic cavity removed through a special thoracotomy that preserves the rib. The neoplasm was removed surgically and was pathologically diagnosed as a spindle cell tumor. Immunohistochemistry results showed that smooth muscle actin (SMA), S100, CD34 and NTRK were positively expressed in tumor tissue. By discussing the pathologic types, diagnosis and treatment of the disease, we can provide more references for clinical diagnosis and treatment of this disease.