人工关节假体周围感染治疗中利福平作用探究

Investigation on the Therapeutic Effect of Rifampicin on Periprosthetic Joint Infection

摘要: 目的：对人工关节假体周围感染治疗中利福平作用进行探究和分析。方法：回顾我院2022年12月到2023年12月期间确诊并且收治的人工关节假体周围感染患者100例，依照正式入院进行治疗时间顺序，将其分为两组，时间顺序中的前者为本文对照组，时间顺序的后者为本文观察组。将具有人工关节假体周围感染的常规抗生素治疗实验对象分配到对照组(50例)，将具有人工关节假体周围感染的利福平治疗实验对象随机分配到观察组(50例)，针对两组患者的治疗有效率进行观察、对比、分析和记录。结果：两组患者人工关节假体周围感染患者使用不同药物治疗之下，取得了差异性的治疗效果，其中观察组患者使用利福平进行治疗的有效率明显比较高，组间差异显著，存在统计学意义，P < 0.05。结论：在针对人工关节假体周围感染治疗工作中，利福平具有显著效果和作用，有助于患者感染的有效控制，对于患者的身心健康和生命安全均具有重要意义和价值，值得在日后的人工关节假体周围感染患者治疗工作中进行全面应用和推广。

Abstract: Purpose: This study aims to investigate and analyze the role of Rifampicin in the treatment of periprosthetic joint infections. Methods: A combination of retrospective analysis and controlled study methods was employed. We reviewed 100 cases of patients diagnosed with and admitted for periprosthetic joint infections in our hospital from December 2022 to December 2023, considering them as the subjects of this study. Based on the chronological order of formal admission for treatment, they were divided into two groups: the former in chronological order constituted the control group, and the latter formed the observation group. Patients with periprosthetic joint infections undergoing conventional antibiotic treatment were allocated to the control group (50 cases), while those receiving Rifampicin treatment were randomly assigned to the observation group (50 cases). The therapeutic efficacy of the two groups was observed, compared, analyzed, and recorded. Results: Under different drug treatments for periprosthetic joint infections in the observation and control groups, significant differences in treatment outcomes were observed. The efficacy of Rifampicin treatment in the observation group was notably higher, with a statistically significant intergroup difference (P < 0.05). Conclusion: In the treatment of periprosthetic joint infections, Rifampicin exhibits a significant effect, contributing to the effective control of infections. It holds crucial significance and value for the physical and mental health as well as the life safety of patients. Therefore, it is worthy of comprehensive periprosthetic joint infections.