甲状腺功能亢进介导肺癌超进展病例报告

Case Report of Hyperprogression of Lung Cancer Mediated by Hyperthyroidism

摘要: 目的：分析甲状腺功能亢进与恶性肿瘤发生发展之间的关系。方法：回顾性分析1例甲状腺功能亢进介导肺癌超进展的患者并复习相关文献。结果：本例老年男性患者，因“咳嗽、咳痰、气促2年余，再发加重3月”入院。既往糖尿病史10年余，甲亢病史5年余，未规律诊治。患者肺部CT平扫不排除肿瘤病变，后经支气管镜活检，结合免疫组化结果，考虑小细胞肺癌。对比其外院2月余前胸部CT结果，考虑肺癌超进展。结论：甲状腺功能亢进可提高肺癌发生发展的易感性。临床医生在诊疗过程中，应加强对甲亢与癌症关联的认识，提高甲亢患者的风险意识，并对癌症患者进行早期识别和明确诊断，以提高患者预后。

Abstract: Objective: To analyze the relationship between hyperthyroidism and the occurrence and development of malignant tumors. Methods: A retrospective analysis was conducted on a case of hyperthyroidism-mediated ultra-progressive lung cancer, along with a review of relevant literature. Result: In this case, an elderly male patient was admitted due to “coughing, expectoration, and dyspnea for over 2 years, exacerbated for 3 months”. He had a medical history of diabetes for more than 10 years and a history of hyperthyroidism for over 5 years, which had not been managed consistently. Pulmonary CT scan suggested possible tumor lesions. Subsequently, bronchoscopic biopsy in combination with immunohistochemical results led to a consideration of small cell lung cancer. Comparing the chest CT findings from over 2 months ago at another hospital, it was concluded that the patient’s lung cancer had undergone ultra-progressive growth. Conclusion: Hyperthyroidism can increase susceptibility to the occurrence and progression of lung cancer. Clinicians should enhance their understanding of the association between hyperthyroidism and cancer during the diagnostic process, raise awareness of the risk among patients with hyperthyroidism, and ensure early recognition and definitive diagnosis of malignancy in these patients, thereby improving patient prognosis.