食管胃结合部癌的治疗进展
Advances in the Treatment of Esophagogastric Junction Cancer
DOI: 10.12677/acm.2024.1451690, PDF,   
作者: 袁 敏：西安医学院研究生工作部，陕西 西安；马 钰：陕西省人民医院病理科，陕西 西安；王建华*：西安医学院研究生工作部，陕西 西安；陕西省人民医院普通外科，陕西 西安
关键词: 食管胃结合部癌；分型；手术治疗；淋巴结清扫；消化道重建；免疫组化；Esophagogastric Junction Carcinoma； Type； Surgical Treatment； Lymph Node Dissection； Digestive Tract Reconstruction； Immunohistochemistry
摘要: 食管胃结合部癌的发病率在全球范围内不断上升，其死亡率也居恶性肿瘤前列，由于肿瘤位置的特殊性，病理分期较晚，患者术后生存较差；手术治疗作为食管胃结合部癌的主要治疗方式，其手术入路、淋巴结清扫范围、消化道的重建均存在着较大的争议；本文主要是从食管胃结合部癌的定义、分型、临床表现、手术入路、淋巴结清扫、消化道重建等方面做一综述，从而为治疗提供参考。
Abstract: The incidence of esophagogastric junction cancer is increasing globally, and its mortality is also at the forefront of malignant tumors. Due to the particularity of tumor location, the pathological stage is late, and the postoperative survival of patients is poor. As the main treatment method of esophagogastric junction cancer, surgical treatment is controversial in terms of surgical approach, lymph node dissection scope and digestive tract reconstruction. This article mainly reviews the definition, type, clinical manifestations, surgical approach, lymph node dissection, digestive tract reconstruction and other aspects of esophagogastric junction cancer, so as to provide reference for treatment.
文章引用：袁敏, 马钰, 王建华. 食管胃结合部癌的治疗进展[J]. 临床医学进展, 2024, 14(5): 2330-2335. https://doi.org/10.12677/acm.2024.1451690

参考文献

[1] 赵恩昊, 赵刚. 食管胃结合部腺癌定义的前世今生[J]. 中华胃肠外科杂志, 2018, 21(2): 165-166.
[2] 王云鹏, 黄伟芃, 樊勇. 食管胃结合部腺癌的外科学治疗研究进展[J]. 现代医学, 2023, 51(12): 1783-1788.
[3] Bai, J.G., Lv, Y. and Dang, C.X. (2006) Adenocarcinoma of the Esophagogastric Junction in China According to Siewert’s Classification. Japanese Journal of Clinical Oncology, 36, 364-367. [Google Scholar] [CrossRef] [PubMed]
[4] Hatta, W., Tong, D. and Lee, Y.Y. (2017) Different Time Trend and Management of Esophagogastric Junction Adenocarcinoma in Three Asian Countries. Digestive Endoscopy, 29, 18-25. [Google Scholar] [CrossRef] [PubMed]
[5] 陈志峰. 食管胃结合部腺癌流行趋势、病因及防治[J]. 中国实用外科杂志, 2012, 32(4): 267-270.
[6] Siewert, J.R., Hölscher, A.H., Becker, K., Gössner, W., et al. (1987) Cardia Cancer: Attempt at a Therapeutically Relevant Classification. Chirurg, 58, 25-32.
[7] Aikou, T. and Shimazu, H. (1989) Difference in Main Lymphatic Pathways from the Lower Esophagus and Gastric Cardia. The Japanese Journal of Surgery, 19, 290-295. [Google Scholar] [CrossRef] 
[8] (2021) Japanese Gastric Cancer Treatment Guidelines 2018 (5th Edition). Gastric Cancer, 24, 1-21. [Google Scholar] [CrossRef] [PubMed]
[9] Giordano, T.J. (2014) The Cancer Genome Atlas Research Network: A Sight to Behold. Endocrine Pathology, 25, 362-365. [Google Scholar] [CrossRef] [PubMed]
[10] 宋旭东, 等. 食管胃结合部腺癌的定义、分型、分期及外科治疗进展[J]. 医学综述, 2021, 27(7): 1318-1322.
[11] 季加孚, 季科. 食管胃结合部腺癌外科治疗进展[J]. 中国普外基础与临床杂志, 2019, 26(9): 1021-1024.
[12] Merendino, K.A. and Dillard, D.H. (1955) The Concept of Sphincter Substitution by an Interposed Jejunal Segment for Anatomic and Physiologic Abnormalities at the Esophagogastric Junction; with Special Reference to Reflux Esophagitis, Cardiospasm and Esophageal Varices. Annals of Surgery, 142, 486-506. [Google Scholar] [CrossRef] [PubMed]
[13] Forastiere, A.A. (2010) Multimodality Treatment of Esophagus Cancer: Current Status and Future Perspectives in the United States. Esophagus: Official Journal of the Japan Esophageal Society, 7, 1-6. [Google Scholar] [CrossRef] 
[14] Shaheen, N.J., Falk, G.W., Iyer, P.G., Gerson, L.B., et al. (2016) ACG Clinical Guideline: Diagnosis and Management of Barrett’s Esophagus. The American Journal of Gastroenterology, 111, 30-50. [Google Scholar] [CrossRef] [PubMed]
[15] Weusten, B., Bisschops, R., Coron, E., Dinis-Ribeiro, M., Dumonceau, J., et al. (2017) Endoscopic Management of Barrett’s Esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy, 49, 191. [Google Scholar] [CrossRef] [PubMed]
[16] 董剑宏, 雷力强. 食管胃结合部腺癌手术入路对手术范围及患者术后影响的研究进展[J]. 中国药物与临床, 2014, 14(5): 618-620.
[17] 国际食管疾病学会中国分会, 等. 食管胃结合部腺癌外科治疗中国专家共识(2018年版) [J]. 中华胃肠外科杂志, 2018, 21(9): 961-975.
[18] Feith, M., Stein, H.J. and Siewert, J.R. (2006) Adenocarcinoma of the Esophagogastric Junction: Surgical Therapy Based on 1602 Consecutive Resected Patients. Surgical Oncology Clinics of North America, 15, 751-764. [Google Scholar] [CrossRef] [PubMed]
[19] Zhang, S., Orita, H. and Fukunaga, T. (2019) Current Surgical Treatment of Esophagogastric Junction Adenocarcinoma. World Journal of Gastrointestinal Oncology, 11, 567-578. [Google Scholar] [CrossRef] [PubMed]
[20] Sloof, G.W., Klaase, J.M., Bergman, J.J., et al. (2004) Lymphatic Drainage Routes of the Gastric Cardia Visualized by Lymphoscintigraphy. Journal of Nuclear Medicine, 45, 247-252.
[21] Csendes, A., Burdiles, P., Rojas, J., Braghetto, I., et al. (2002) A Prospective Randomized Study Comparing D2 Total Gastrectomy versus D2 Total Gastrectomy plus Splenectomy in 187 Patients with Gastric Carcinoma. Surgery, 131, 401-407. [Google Scholar] [CrossRef] [PubMed]
[22] 任双义, 孙伟峰. 食管胃结合部腺癌的外科手术治疗[J]. 大连医科大学学报, 2013, 35(5): 502-505.
[23] 石晓鹏, 等. Caveolin-1基因的甲基化状态与食管胃结合部腺癌中Caveolin-1mRNA, Caveolin-1蛋白及Her-2蛋白表达的相关性[J]. 临床与病理杂志, 2020, 40(2): 281-289.
[24] 吴冠楠, 刘家云, 姚学权, 等. SATB1在SiewertII、III型胃食管结合部腺癌中的表达及与临床病理特征的关系[J]. 现代肿瘤医学, 2017, 25(16): 2601-2605.
[25] 闫静波, 等. 血管内皮生长因子和微血管密度在食管胃结合部腺癌组织中的表达及临床意义[J]. 癌症进展, 2019, 17(17): 2062-2065.

为你推荐