HGMUE的相关研究
Studies on Heterotopic Gastric Mucosa in the Upper Esophagus
DOI: 10.12677/acm.2024.1451692, PDF,  被引量    科研立项经费支持
作者: 覃秀敏, 余晓云*:华中科技大学同济医学院附属协和医院消化内科,湖北 武汉
关键词: 食管上段胃黏膜异位咽喉症状H -K -ATP酶Ectopic Gastric Mucosa of Upper Esophagus Pharynx and Larynx Symptoms H -K -ATP Enzyme
摘要: 食管上段异位胃黏膜异位症(Heterotopic gastric mucosa in the upper esophagus, HGMUE)以往被认为是无症状性病灶,随着内镜技术的发展和对疾病认识的增加,越来越多的研究证实HGMUE可能与咽喉部症状产生相关。本文讨论了HGMUE患者咽喉部症状的发生情况和其组织学特点,分析了HGMUE引起咽喉部组织的可能因素。
Abstract: Heterotopic gastric mucosa in the upper esophagus (HGMUE) was previously considered to be an asymptomatic focus. With the development of endoscopic techniques and increased understanding of the disease, more and more studies have confirmed that HGMUE may be related to pharynx and larynx symptoms. In this paper, the occurrence and histological characteristics of pharynx and larynx symptoms in patients with HGMUE were discussed, and the possible factors of throat tissue caused by HGMUE were analyzed.
文章引用:覃秀敏, 余晓云. HGMUE的相关研究[J]. 临床医学进展, 2024, 14(5): 2341-2346. https://doi.org/10.12677/acm.2024.1451692

参考文献

[1] Sahin, G., Adas, G., Koc, B., et al. (2014) Is Cervical Inlet Patch Important Clinical Problem? International Journal of Biomedical Science, 10, 129-135. [Google Scholar] [CrossRef
[2] Akar, T. and Aydin, S. (2022) The True Prevalence of Cervical Inlet Patch in a Specific Center Dealing with Esophageal Diseases. European Review for Medical and Pharmacological Sciences, 26, 3127-3131.
[3] Neumann, W.L., Luján, G.M. and Genta, R.M. (2012) Gastric Heterotopia in the Proximal Oesophagus (“Inlet Patch”): Association with Adenocarcinomas Arising in Barrett Mucosa. Digestive and Liver Disease, 44, 292-296. [Google Scholar] [CrossRef] [PubMed]
[4] Peitz, U., Vieth, M., Evert, M., et al. (2017) The Prevalence of Gastric Heterotopia of the Proximal Esophagus Is Underestimated, but Preneoplasia Is Rare-Correlation with Barrett’s Esophagus. BMC Gastroenterology, 17, Article No. 87. [Google Scholar] [CrossRef] [PubMed]
[5] 王静, 平付敏, 朱庆华, 等. 食管上段胃黏膜异位的发病率及危险因素研究[J]. 河北医药, 2019, 41(14): 2161-2164.
[6] Chong, V.H. (2011) Heterotopic Gastric Mucosal Patch of the Proximal Esophagus. In: Pascu, O., Ed., Gastrointestinal Endoscopy, IntechOpen, Rijeka, 125-148. [Google Scholar] [CrossRef
[7] 年媛媛, 孟宪梅, 陈洪锁, 等. 1229例食管胃黏膜异位的临床和组织学特点分析[J]. 胃肠病学, 2021, 26(2): 112-115.
[8] Rusu, R., Ishaq, S., Wong, T., et al. (2018) Cervical Inlet Patch: New Insights into Diagnosis and Endoscopic Therapy. Frontline Gastroenterology, 9, 214-220. [Google Scholar] [CrossRef] [PubMed]
[9] Von Rahden, B.H.A., Stein, H.J., Becker, K., et al. (2004) Heterotopic Gastric Mucosa of the Esophagus: Literature-Review and Proposal of a Clinicopathologic Classification. American Journal of Gastroenterology, 99, 543-551. [Google Scholar] [CrossRef] [PubMed]
[10] 王长青, 刘政. 食管上段胃黏膜异位症的内镜诊治进展[J]. 医学综述, 2015, 21(7): 1280-1282.
[11] Sciarra, A., Hessler, R., Godat, S., et al. (2018) Heterotopic Gastric Mucosa in a Duplication Cyst of the Common Hepatic Duct Mimicking Cholangiocarcinoma. International Journal of Surgical Pathology, 26, 84-88. [Google Scholar] [CrossRef] [PubMed]
[12] Lupu, V.V., Ignat, A., Paduraru, G., et al. (2015) Heterotopic Gastric Mucosa in the Distal Part of Esophagus in a Teenager Case Report. Medicine, 94, e1722. [Google Scholar] [CrossRef
[13] Salem, G.A., Fazili, J. and Ali, T. (2017) Gastric Heterotopia in the Rectum. A Rare Cause of Ectopic Gastric Tissue. Arab Journal of Gastroenterology, 18, 42-43. [Google Scholar] [CrossRef] [PubMed]
[14] 平付敏, 郭永泽, 王静, 等. 食管胃黏膜异位检出率的影响因素分析及其对食管检查质量评价的研究[J]. 河北医科大学学报, 2017, 38(6): 642-645.
[15] 王迎伟, 李运泽, 龙颖, 等. 食管胃黏膜异位内镜检出率的影响因素分析[J]. 中国内镜杂志, 2020, 26(11): 36-40.
[16] Cheng, C.-L., et al. (2014) Endoscopic Diagnosis of Cervical Esophageal Heterotopic Gastric Mucosa with Conventional and Narrow-Band Images. World Journal of Gastroenterology, 20, 242-249. [Google Scholar] [CrossRef] [PubMed]
[17] 钟伟志, 杨军强. 食管上段胃黏膜异位症的研究现状[J]. 中外医学研究, 2022, 20(28): 177-180.
[18] Yamada, T., Tsuji, A., Onoue, S., et al. (2017) Acid Suppressive Therapy Improved Symptoms Due to Circumferential Cervical Inlet Patch with Proton Pumps (H /K -ATPase). World Journal of Clinical Cases, 5, 403-406. [Google Scholar] [CrossRef] [PubMed]
[19] Chong, V.H. (2018) Cervical Inlet Patch: An Important Cause of Globus Pharyngeus. European Archives of Oto-Rhino-Laryngology, 275, 3101-3102. [Google Scholar] [CrossRef] [PubMed]
[20] Chong, V.H. and Jalihal, A. (2010) Heterotopic Gastric Mucosal Patch of the Esophagus Is Associated with Higher Prevalence of Laryngopharyngeal Reflux Symptoms. European Archives of Oto-Rhino-Laryngology, 267, 1793-1799. [Google Scholar] [CrossRef] [PubMed]
[21] Baudet, J.-S., Alarcon-Fernandez, O., Sanchez Del Rio, A., et al. (2009) Heterotopic Gastric Mucosa: A Significant Clinical Entity. Scandinavian Journal of Gastroenterology, 41, 1398-1404. [Google Scholar] [CrossRef] [PubMed]
[22] Poyrazoglu, O.K., Bahcecioglu, I.H., Dagli, A.F., et al. (2009) Heterotopic Gastric Mucosa (Inlet Patch): Endoscopic Prevalence, Histopathological, Demographical and Clinical Characteristics. International Journal of Clinical Practice, 63, 287-291. [Google Scholar] [CrossRef] [PubMed]
[23] 杨冬, 王贞, 战秀岚, 等. 伴食管外症状的胃食管反流病患者180例的临床表现和食管动力学特征分析[J]. 中华消化杂志, 2021, 41(2): 94-99.
[24] 张婧曦, 孟宪梅, 周怡, 等. 食管上段胃黏膜异位症的研究现状[J]. 包头医学院学报, 2015, 31(1): 149-150.
[25] 宋学诗. 食管胃黏膜异位的临床病例分析[D]: [硕士学位论文]. 大连: 大连医科大学, 2022.
[26] Yu, X., Wang, J., Jin, T., et al. (2022) Laryngopharyngeal Symptoms and Oesophageal Disorder: The Role of Heterotopic Gastric Mucosa in Upper Oesophagus. Clinical Otolaryngology, 48, 32-38. [Google Scholar] [CrossRef] [PubMed]
[27] Galan, A.R., Katzka, D.A. and Castell, D.O. (1998) Acid Secretion from an Esophageal Inlet Patch Demonstrated by Ambulatory pH Monitoring. Gastroenterology, 115, 1574-1576. [Google Scholar] [CrossRef
[28] Kim, E.A., Kang, D.H., Cho, H.S., et al. (2001) Acid Secretion from a Heterotopic Gastric Mucosa in the Upper Esophagus Demonstrated by Dual Probe 24-Hour Ambulatory pH Monitoring. Korean Journal of Internal Medicine, 16, 14-17. [Google Scholar] [CrossRef] [PubMed]
[29] Korkut, E., Bektas, M., Alkan, M., et al. (2010) Esophageal Motility and 24-h pH Profiles of Patients with Heterotopic Gastric Mucosa in the Cervical Esophagus. European Journal of Internal Medicine, 21, 21-24. [Google Scholar] [CrossRef] [PubMed]
[30] 张春芬, 陈宏伟, 李延伟. 上食管胃黏膜异位症的临床与病理分析[J]. 中国慢性病预防与控制, 2011, 19(5): 485-486.
[31] 吴瑞暖, 刘朝晖. 食管胃黏膜异位病理诊断分型与临床症状的关系[J]. 海南医学, 2020, 31(11): 1377-1379.
[32] 周禾, 杨涛, 王海昆, 等. 食管上段胃黏膜异位的病理分型和临床症状特点[J]. 中华消化杂志, 2020, 40(6): 5.
[33] Hamilton, J.W., Thune, R.G. and Morrissey, J.F. (1986) Symptomatic Ectopic Gastric Epithelium of the Cervical Esophagus. Demonstration of Acid Production with Congo Red. Digestive Diseases and Sciences, 31, 337-342. [Google Scholar] [CrossRef
[34] Weickert, U., Wolf, A., Schroeder, C., et al. (2011) Frequency, Histopathological Findings, and Clinical Significance of Cervical Heterotopic Gastric Mucosa (Gastric Inlet Patch): A Prospective Study in 300 Patients. Diseases of the Esophagus, 24, 63-68. [Google Scholar] [CrossRef] [PubMed]
[35] 汪家琪. 食管胃黏膜异位症的临床特点研究[D]: [硕士学位论文]. 武汉: 华中科技大学, 2020.
[36] Woodland, P., Shen Ooi, J.L., Grassi, F., et al. (2017) Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease. Gastroenterology, 153, 1230-1239. [Google Scholar] [CrossRef] [PubMed]
[37] Buse, P.E., Zuckerman, G.R. and Balfe, D.M. (1993) Cervical Esophageal Web Associated with a Patch of Heterotopic Gastric Mucosa. Abdominal Imaging, 18, 227-228. [Google Scholar] [CrossRef
[38] Bataller, R., Bordas, J.M., Ordi, J., et al. (1995) Upper Gastrointestinal Bleeding: A Complication of “Inlet Patch Mucosa” in the Upper Esophagus. Endoscopy, 27, 282. [Google Scholar] [CrossRef] [PubMed]
[39] Lauwers, G.Y., Scott, G.V. and Vauthey, J.N. (1998) Adenocarcinoma of the Upper Esophagus Arising in Cervical Ectopic Gastric Mucosa: Rare Evidence of Malignant Potential of So-Called “Inlet Patch”. Digestive Diseases and Sciences, 43, 901-907. [Google Scholar] [CrossRef
[40] Chatelain, D., De Lajarte-Thirouard, A.-S., Tiret, E., et al. (2002) Adenocarcinoma of the Upper Esophagus Arising in Heterotopic Gastric Mucosa: Common Pathogenesis with Barrett’s Adenocarcinoma? Virchows Archiv, 441, 406-411. [Google Scholar] [CrossRef] [PubMed]
[41] Garcia, A.O., Mazzadi, S.A., Raffo, L., et al. (2002) Heterotopic Gastric Mucosa in the Upper Esophagus: Report of a Case with a Fistula. Diseases of the Esophagus, 15, 262-265. [Google Scholar] [CrossRef] [PubMed]
[42] Ward, E.M. and Achem, S.R. (2003) Gastric Heterotopia in the Proximal Esophagus Complicated by Stricture. Gastrointestinal Endoscopy, 57, 131-133. [Google Scholar] [CrossRef] [PubMed]
[43] Righini, C.A., Faure, C., Karkas, A., et al. (2007) Spontaneous Perforation in the Upper Oesophagus Resulting from Ulcer in Heterotopic Gastric Mucosa. Revue de Laryngologie-Otologie-Rhinologie, 128, 197-200.
[44] Katsanos, K.H., Christodoulou, D.K., Kamina, S., et al. (2010) Diagnosis and Endoscopic Treatment of Esophago-Bronchial Fistula Due to Gastric Heterotopy. World Journal of Gastrointestinal Endoscopy, 2, 138-142. [Google Scholar] [CrossRef] [PubMed]
[45] Komori, S., Osada, S., Tanaka, Y., et al. (2010) A Case of Esophageal Adenocarcinoma Arising from the Ectopic Gastric Mucosa in the Thoracic Esophagus. Rare Tumors, 2, 12-15. [Google Scholar] [CrossRef] [PubMed]
[46] Dziadkowiec, K.N., Sanchez-Luna, S.A., Stawinski, P., et al. (2022) Adenocarcinoma Arising from a Cervical Esophageal Inlet Patch: The Malignant Potential of a Small Lesion. Cureus, 14, c74. [Google Scholar] [CrossRef] [PubMed]
[47] Kitasaki, N., Hamai, Y., Yoshikawa, T., et al. (2022) Recurrent Esophageal Adenocarcinoma Derived from Ectopic Gastric Mucosa: A Case Report. Thoracic Cancer, 13, 876-879. [Google Scholar] [CrossRef] [PubMed]
[48] Patel, A. and Ajumobi, A.B. (2023) Esophageal Stricture: An Uncommon Complication of Cervical Inlet Patch. Journal of Investigative Medicine High Impact Case Reports, 11, 23247096231201024. [Google Scholar] [CrossRef] [PubMed]
[49] Habermann, W., Schmid, C., Neumann, K., et al. (2012) Reflux Symptom Index and Reflux Finding Score in Otolaryngologic Practice. Journal of Voice, 26, E123-E127. [Google Scholar] [CrossRef] [PubMed]
[50] 张来启, 刘小玉. 食管上段胃粘膜异位症30例临床分析[J]. 陕西医学杂志, 2010, 39(7): 820-821.
[51] 朱海杭, 陈洁, 卜平. 食管上段胃黏膜异位症的研究近况[J]. 中国内镜杂志, 2011, 17(10): 1043-1046, 1052.
[52] 房殿春. 食管胃黏膜异位的诊治现状[J]. 现代消化及介入诊疗, 2013, 18(1): 21-23.