儿童卵巢幼年型颗粒细胞瘤的单中心回顾性研究

A Single Center Retrospective Study of Ovarian Juvenile Granulosa Cell Tumor in Children

摘要: 背景：卵巢幼年型颗粒细胞瘤(Juvenile Granulosa Cell Tumor, JGCT)十分罕见，尤其是在儿童。目的：探讨儿童卵巢JGCT的病史特点、治疗方法和预后情况。材料与方法：回顾性分析我院2013年10月至2020年12月收治的15例卵巢JGCT的患儿的临床资料。结果：患儿的发病年龄范围8月~11岁，中位年龄3岁。首发症状为性早熟者占40% (6/15)，腹部包块者占40% (6/15)。肿瘤位置右侧9例，左侧6例，均为单侧发病。肿块的性质囊实性12例，囊性2例，实性1例。根据国际妇产科学联合会(FIGO)的标准，IA期10例，IC期5例。患儿的中位随访时间为29个月。通过保留生育手术，联合或者未联合辅助化疗，15例患儿全部临床治愈，随访期间无复发现象。结论：发生在儿童时期的卵巢JGCT基本都处于早期阶段，常见的症状为性早熟和腹部包块，保留生育的手术非常有效，且预后良好。

Abstract: Background: Juvenile granulosa cell tumor (JGCT) of the ovary is very rare, especially in children. Objective: To explore the clinical history, treatment methods, and prognosis of ovarian JGCT in children. Materials and Methods: A retrospective analysis was conducted on the clinical data of 15 children with ovarian JGCT who were treated in our hospital from October 2013 to December 2020. Results: The age range of the patients was from 8 months to 11 years, with a median age of 3 years. The initial symptoms were precocious puberty in 40% (6/15) of the patients and abdominal mass in 40% (6/15). The tumor was located on the right side in 9 cases and on the left in 6 cases, all were unilateral. The nature of the tumor was cystic-solid in 12 cases, cystic in 2 cases, and solid in 1 case. According to the International Federation of Gynecology and Obstetrics (FIGO) standards, 10 cases were stage IA and 5 cases were stage IC. The median follow-up time for the patients was 29 months. All 15 patients were clinically cured through fertility-sparing surgery, with or without adjuvant chemotherapy, and there were no recurrences during the follow-up period. Conclusion: Ovarian JGCTs in children are mostly in the early stages, with common symptoms being precocious puberty and abdominal mass. Fertility-sparing surgery is very effective and the prognosis is good.