非编码RNA在胆管癌化疗耐药中的作用机制研究进展

Research Progress on the Mechanism of Non-Coding RNA in Chemotherapy Resistance of Cholangiocarcinoma

摘要: 胆管癌(Cholangiocarcinoma)作为一种恶性程度高、预后差、手术切除率低的重大疾病，对人类健康构成了严重威胁。对于晚期或无法手术的患者，化疗成为关键的治疗手段。然而，化疗耐药性的问题一直是临床治疗的难题，其背后的机制复杂且涉及多因素。近年来的研究发现，在胆管癌中，非编码RNA的异常表达通过调控细胞凋亡、细胞周期、上皮–间质转化(EMT)以及细胞自噬等关键生物学过程，显著影响肿瘤对化疗药物的敏感性。本综述旨在梳理当前关于非编码RNA在胆管癌耐药性调控中的分子机制的研究进展，并探讨靶向非编码RNA以克服胆管癌耐药性的潜力，旨在为胆管癌的治疗策略提供创新思路，并为开发新的治疗药物奠定理论基础。

Abstract: Cholangiocarcinoma, as a major disease with high malignancy, poor prognosis, and low surgical resection rate, poses a serious threat to human health. For late stage or inoperable patients, chemotherapy becomes a key treatment option. However, the issue of chemotherapy resistance has always been a challenge in clinical treatment, and the underlying mechanisms are complex and involve multiple factors. In recent years, research has found that abnormal expression of non-coding RNA in cholangiocarcinoma significantly affects the sensitivity of tumors to chemotherapy drugs by regulating key biological processes such as cell apoptosis, cell cycle, epithelial mesenchymal transition (EMT), and cell autophagy. This review aims to review the current research progress on the molecular mechanisms of non-coding RNA in the regulation of drug resistance in cholangiocarcinoma, and explore the potential of targeting non-coding RNA to overcome drug resistance in cholangiocarcinoma. The aim is to provide innovative ideas for the treatment strategy of cholangiocarcinoma and lay a theoretical foundation for the development of new therapeutic drugs.