FOXA1在恶性肿瘤中的作用及其机制研究进展
The Role of FOXA1 in Malignant Tumors and the Progress of Its Mechanism Research
DOI: 10.12677/acm.2024.1451704, PDF,   
作者: 杜文艳, 张一粟, 安 昕：甘肃中医药大学第一临床医学院，甘肃 兰州；王 干：白银市中心医院检验科，甘肃 白银；李 卓：甘肃省中医院，甘肃 兰州；刘 华*：甘肃省人民医院呼吸与危重症医学科，甘肃 兰州
关键词: 叉头框蛋白；恶性肿瘤；转录因子；信号通路；Forkhead Box Protein； Malignant Tumor； Transcription Factor； Signaling Pathway
摘要: 叉头框蛋白A1 (forkhead-box A1, FOXA1)是叉头框(FOX)转录因子家族的成员。FOXA1主要是在胚胎产生、调控细胞的增殖与分化、人体器官生长发育及代谢调整等生理环节中发挥极为重要的调控功效。越来越多的研究表明FOXA1与肿瘤发生发展有关，多种研究表明它在肝癌、乳腺癌、前列腺癌、肺癌、结肠癌等多种恶性肿瘤中出现异常表达，影响患者愈后与生存。随着研究的不断深入，FOXA1在恶性肿瘤中的作用及其机制被揭示，因此本文主要阐述FOXA1在恶性肿瘤中的作用及其机制，对最新研究进展作一综述，以期为肿瘤的预防与防治提供帮助。
Abstract: Forkhead-box A1 (FOXA1) is a member of the forkhead-box (FOX) family of transcription factors, and FOXA1 plays an important role in embryogenesis, cell proliferation and differentiation, organ growth and metabolism, and other physiological processes. More and more researches have shown that FOXA1 is related to the development trend of tumorigenesis. Various studies have shown that it is abnormally expressed in various malignant tumors such as liver, breast, prostate, lung and colon cancers, which affects the survival of the patients and the development of their prognosis. With the deepening of research, the role and mechanism of FOXA1 in malignant tumors have been revealed. Therefore, this paper mainly describes the role of FOXA1 in malignant tumors and its mechanism, and gives an overview of the latest research progress, with a view to providing help for the prevention and control of tumors.
文章引用：杜文艳, 王干, 李卓, 张一粟, 安昕, 刘华. FOXA1在恶性肿瘤中的作用及其机制研究进展[J]. 临床医学进展, 2024, 14(5): 2434-2440. https://doi.org/10.12677/acm.2024.1451704

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